Results 171 to 180 of about 6,423,279 (401)

A multimodal model for protein function prediction

Scientific Reports
Protein function, which is determined by sequence, structure, and other characteristics, plays a crucial role in an organism’s performance. Existing protein function prediction methods mainly rely on sequence data and often ignore structural properties ...
Yu Mao, WenHui Xu, Yue Shun, LongXin Chai, Lei Xue, Yong Yang, Mei Li   +6 more
doaj   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Discovery of Cyclic Acylguanidines as Highly Potent and Selective β-Site Amyloid Cleaving Enzyme (BACE) Inhibitors: Part I—Inhibitor Design and Validation

, 2009
Zhaoning Zhu, Z. J. Sun, Yuanzan Ye, Johannes Voigt, Corey Strickland, Elizabeth M. Smith, Jared N. Cumming, Lingyan Wang, J.K.Y. Wong, Yu‐Sen Wang, Daniel F. Wyss, Xia Chen, Reshma Kuvelkar, Kristen M. Kennedy, Leonard Favreau, Eric M. Parker, Brian A. McKittrick, Andrew W. Stamford, Michael Czarniecki, William J. Greenlee, John C. Hunter   +20 more
openalex   +1 more source

Hormonal Regulation of Hepatic Drug-Metabolizing Enzyme Activity During Adolescence [PDF]

, 2008
MJ Kennedy
openalex   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Isofunctional Enzymes PAD1 and UbiX Catalyze Formation of a Novel Cofactor Required by Ferulic Acid Decarboxylase and 4-Hydroxy-3-polyprenylbenzoic Acid Decarboxylase

, 2015
Fengming Lin, Kyle L. Ferguson, David R. Boyer, Xiaoxia Nina Lin, E. Neil G. Marsh   +4 more
openalex   +2 more sources

Function-Structure Studies and Identification of Three Enzyme Domains Involved in the Catalytic Activity in Rat Hepatic Squalene Synthase [PDF]

, 1998
Peide Gu, Yoshinori Ishii, Thomas A. Spencer, Ishaiahu Shechter   +3 more
openalex   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Global probabilistic annotation of metabolic networks enables enzyme discovery

, 2012
Germán Plata, Tobias Fuhrer, Tzu‐Lin Hsiao, Uwe Sauer, Dennis Vitkup   +4 more
openalex   +2 more sources

Arabidopsis Encodes Four tRNase Z Enzymes [PDF]

, 2009
Giusy Canino, Edyta Bocian, Nicolas Barbezier, Manuel Echeverrı́a, Joachim Forner, Stefan Binder, Anita Marchfelder   +6 more
openalex   +1 more source