Results 131 to 140 of about 1,619,601 (310)

Substrate-competitive activity-based profiling of ester prodrug activating enzymes

, 2018
Brent R. Martin
openalex   +2 more sources

Figure S1 from <i>In Vivo</i> Antitumoral Efficacy of PhAc-ALGP-Doxorubicin, an Enzyme-Activated Doxorubicin Prodrug, in Patient-Derived Soft Tissue Sarcoma Xenograft Models

, 2023
Jasmien Cornillie, Agnieszka Woźniak, Péter Pokreisz, Andrea Casazza, Lise Vreys, Jasmien Wellens, Ulla Vanleeuw, Yemarshet K. Gebreyohannes, Maria Dêbiec‐Rychter, Raf Sciot, Daphne Hompes, Patrick Schöffski   +11 more
openalex   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

An enzyme activation network reveals extensive regulatory crosstalk between metabolic pathways. [PDF]

Mol Syst Biol
Al Zubaidi SM, Nasar MI, Notebaart RA, Ralser M, Alam MT.   +4 more
europepmc   +1 more source

Structure, function and inhibition of poly(ADP-ribose)polymerase, member 14 (PARP14) [PDF]

, 2018
Levonis, Stephan M, Schweiker, Stephanie S, Sherry, Madeleine, Tauber, Amanda   +3 more
core   +1 more source

Inhibitor-induced enzyme activation in organic solvents.

, 1988
Alan J. Russell, Alexander M. Klibanov
openalex   +1 more source

FCS of Mutated Phosphatidylinositol-specific Phospholipase C Enzymes Monitors the Interplay of Substrate and Activator Lipid Binding [PDF]

, 2009
Mingming Pu, Mary F. Roberts, Anne Gershenson   +2 more
openalex   +1 more source

The B12-independent glycerol dehydratase activating enzyme from Clostridium butyricum cleaves SAM to produce 5′-deoxyadenosine and not 5′-deoxy-5′-(methylthio)adenosine

, 2021
William G. Walls, James Moody, Elizabeth C. McDaniel, María Villanueva, Eric M. Shepard, William E. Broderick, Joan Broderick   +6 more
openalex   +2 more sources

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Frequency-Dependent Premature Differentiation of Pheochromocytoma Cells Exhibits Band-Pass Filter Behavior Correlation with Intracellular Enzyme Activation Kinetics. [PDF]

Int J Mol Sci
Ningsih Z, Tran NHN, Clayton AHA.
europepmc   +1 more source