Results 151 to 160 of about 1,619,601 (310)

Carboxypeptidase in prolyl oligopeptidase family: Unique enzyme activation and substrate-screening mechanisms. [PDF]

J Biol Chem, 2019
Yadav P, Goyal VD, Gaur NK, Kumar A, Gokhale SM, Jamdar SN, Makde RD.   +6 more
europepmc   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Ibrutinib-induced pulmonary angiotensin-converting enzyme activation promotes atrial fibrillation in rats. [PDF]

iScience
Yan S, Xu W, Fang N, Li L, Yang N, Zhao X, Hao H, Zhang Y, Liang Q, Wang Z, Duan Y, Zhang S, Gong Y, Li Y.   +13 more
europepmc   +1 more source

Tunable Supramolecular Assemblies from Amphiphilic Nucleoside Phosphoramidate Nanofibers by Enzyme Activation. [PDF]

Biomacromolecules, 2018
West HT, Csizmar CM, Wagner CR.
europepmc   +1 more source

Activation of cancer protective enzymes by flavonoids

, 2006
Y.Y. Lee, A.M.J.F. Boerboom, Algueró Martín, Willem J. H. van Berkel, Ivonne M.C.M. Rietjens, J.M.M.J.G. Aarts   +5 more
openalex   +1 more source

Phosphorylation within an Autoinhibitory Domain in Endothelial Nitric Oxide Synthase Reduces the Ca²⁺Concentrations Required for Calmodulin To Bind and Activate the Enzyme

, 2008
Quang‐Kim Tran, Jared Leonard, D. J. Black, Anthony Persechini   +3 more
openalex   +2 more sources

Cotargeting TREM2 and IL2 pathways triggers multipronged anticancer immunity

Molecular Oncology, EarlyView.
Von Locquenghien et al. report that MiTE‐144, a triggering receptor expressed on myeloid cells 2 (TREM2) blocking antibody fused to interleukin‐2 (IL2) variant with tumour microenvironment restricted activation, demonstrates superior anticancer efficiency in a preclinical setting.
Isaure Vanmeerbeek, Jenny Sprooten, Abhishek D. Garg   +2 more
wiley   +1 more source

Effect of mitochondrial calcium homeostasis-mediated endogenous enzyme activation on tenderness of beef muscle based on MCU modulators. [PDF]

Food Chem X
Ding Z, Liu C, Zhang Z, Zhang C, Huang F.   +4 more
europepmc   +1 more source

Mechanistic Origins of Enzyme Activation in Human Glucokinase Variants Associated with Congenital Hyperinsulinism. [PDF]

Biochemistry, 2018
Sternisha SM, Liu P, Marshall AG, Miller BG.   +3 more
europepmc   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source