Results 181 to 190 of about 6,536,634 (394)
Identifying prognostic targets in metastatic prostate cancer beyond AR
FEBS Open Bio, EarlyView.Genome‐wide functional screens combined with a large gene expression database and clinical outcomes can identify new therapeutic vulnerabilities in prostate cancer. Eight potentially druggable targets demonstrated strong dependency in cell lines, were associated with worse prognosis clinically, and showed evidence of protein expression in prostate ...
Emily Feng +13 more
wiley +1 more source
Reactions Sequence of Leucine Activation Catalysed by Leucyl-RNA Synthetase. 2. Formation of Complexes between the Enzyme and Substrates [PDF]
, 1968 Pierre Rouget, F. Chapeville
openalex +1 more source
Current trends in single‐cell RNA sequencing applications in diabetes mellitus
FEBS Open Bio, EarlyView.Single‐cell RNA sequencing is a powerful approach to decipher the cellular and molecular landscape at a single‐cell resolution. The rapid development of this technology has led to a wide range of applications, including the detection of cellular and molecular mechanisms and the identification and introduction of novel potential diagnostic and ...
Seyed Sajjad Zadian +6 more
wiley +1 more source
Communications BiologyStaphylococcus aureus signal peptidase IB (SpsB) is an essential enzyme for protein secretion. While inhibition of its activity by small molecules is a well-precedented mechanism to kill bacteria, the mode of activation is however less understood.
Shu-Yu Chen +8 more
doaj +1 more source
FEBS Open Bio, EarlyView.Cleavable N‐terminal Thioredoxin fusion enabled soluble expression and purification of otherwise insoluble SARS‐CoV‐2 Nucleocapsid (N) protein. A four‐step purification strategy yielded highly homogeneous, RNA‐free N protein. Binding assays showed high RNA affinity (Kd ~ 28 nm). The study will facilitate high‐resolution structural studies of N protein,
Shweta Singh, Gagan D. Gupta
wiley +1 more source
Intracellular concentration of cysteine in Escherichia coli and its relation to repression of the sulphate-activating enzymes [PDF]
, 1967 J.F. Wheldrake
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Interaction of class III cellobiose dehydrogenase with lytic polysaccharide monooxygenase
FEBS Open Bio, EarlyView.The activity of lytic polysaccharide monooxygenase (LPMO) is supported by its auxiliary enzyme cellobiose dehydrogenase (CDH). The catalytic activity of both enzymes is coupled by electron transfer and a cyclic cascade generating substrates for both enzymes – hydrogen peroxide for LPMO and oxidized and non‐oxidized cellobiose and cello‐oligosaccharide ...
Angela Giorgianni +4 more
wiley +1 more source
Simultaneous Activation of Pentose Phosphate Shunt Enzymes in a Virus-infected Local Lesion Host Plant [PDF]
, 1962 F. Solymosy, G. L. Farkas
openalex +1 more source
FEBS Open Bio, EarlyView.Fervidibacter sacchari is a member of the bacterial phylum Armatimonadota, only a few of which have been cultivated. It is a hyperthermophilic polysaccharide degradation specialist. We show that a secreted enzyme, Fsa02490Xyn, is an endoxylanase belonging to glycoside hydrolase family 10.
Nicole Torosian +10 more
wiley +1 more source
Characterization of Glucose Oxidase from Penicillium notatum
Food Technology and Biotechnology, 2009 In the present study glucose oxidase (GOD) has been isolated from a culture filtrate of Penicillium notatum. The enzyme was purified by ammonium sulphate precipitation, diethylaminoethyl (DEAE) cellulose ion-exchange chromatography and Sephadex gel ...
Nabeela Saleem, Haq Nawaz Bhatti
doaj