Results 201 to 210 of about 6,536,634 (394)

Elastase-alpha1-proteinase inhibitor complex [PDF]

, 1984
Bergmeyer, H. U., Bergmeyer, J., Graßl, M., Jochum, Marianne, Neumann, S.   +4 more
core   +1 more source

The enzymic synthesis of aryl sulphamates. 3. The specificity and mechanism of the activation of rat-Liver arylamine sulphokinase by 17-oxo steroids [PDF]

, 1962
AB Roy
openalex   +1 more source

Long-range Electrostatic Complementarity Governs Substrate Recognition by Human Chymotrypsin C, a Key Regulator of Digestive Enzyme Activation*

Journal of Biological Chemistry, 2013
J. Batra, A. Szabó, T. Caulfield, A. Soares, M. Sahin-Tóth, E. Radisky   +5 more
semanticscholar   +1 more source

Two‐way inhibition of PAX5 transcriptional activity by PAX5::CBFA2T3

FEBS Open Bio, EarlyView.
PAX5::CBFA2T3 (PAX5‐C) is a fusion protein of the B‐cell transcription factor, PAX5, and is found in B‐cell ALL. We propose a putative model of two‐way inhibition of PAX5 transcriptional activity by PAX5‐C. There are two ways of repression by PAX5‐C: DNA‐binding‐dependent way and HDAC‐dependent way, with either being sufficient for the repression. HDAC
Reina Ueno, Aki Terasaki, Yuiko Imai, Yuri Kimura, Yuna Kojima, Misa Irie, Koya Odaira, Mina Noura, Shuichi Okamoto, Takahiko Yasuda, Shinobu Tsuzuki, Hitoshi Kiyoi, Fumihiko Hayakawa   +12 more
wiley   +1 more source

Activation of the IκB Kinase Complex by TRAF6 Requires a Dimeric Ubiquitin-Conjugating Enzyme Complex and a Unique Polyubiquitin Chain

Cell, 2000
L. Deng, chen wang, E. Spencer, Liyong Yang, A. Braun, J. You, C. Slaughter, C. Pickart, Zhijian J. Chen   +8 more
semanticscholar   +1 more source

Stromagenesis and cancer‐associated fibroblast heterogeneity in primary tumors and metastasis: focus in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
Cancer‐associated fibroblasts (CAFs) play different roles in NSCLC progression and metastasis. Their heterogeneous origins and phenotypes shape the tumor microenvironment and influence metastatic spread. This review highlights NSCLC CAF subtypes, their potential cellular sources, and their differential distribution across primary tumors and distant ...
Alejandro Bernardo, Natalia Díaz‐Valdivia, Patricia Fernández‐Nogueira, Jordi Alcaraz   +3 more
wiley   +1 more source

Studies on the Mechanism of Glutamine Synthesis: Evidence for the Formation of Enzyme-bound Activated Glutamic Acid

, 1962
P. R. Krishnaswamy, Vaira Pamiljans, Alton Meister   +2 more
openalex   +1 more source

New mitochondrial DNA synthesis enables NLRP3 inflammasome activation

Nature, 2018
Zhenyu Zhong, Shuang Liang, E. Sanchez-Lopez, Feng He, S. Shalapour, Xue-jia Lin, J. Wong, Siyuan Ding, E. Seki, B. Schnabl, A. Hevener, H. Greenberg, T. Kisseleva, M. Karin   +13 more
semanticscholar   +1 more source

Statins induce monocytic differentiation in acute myeloid leukemia cells through the KLF4/DPYSL2A axis

FEBS Open Bio, EarlyView.
Statins, identified via the Comparative Toxicogenomics Database, promote monocytic differentiation and apoptosis in non‐APL AML cells by upregulating DPYSL2A through a KLF4‐dependent pathway. Mevalonate supplementation reversed these effects, indicating involvement of the mevalonate pathway.
Mina Noura, Kota Shoji, Michidai Nobe, Moe Ishikawa, Miu Tanaka, Akiko Okayama, Souichi Adachi, Hidemasa Matsuo   +7 more
wiley   +1 more source

Transcriptional regulation of neuropeptide receptors underlies context‐dependent adaptation in Drosophila melanogaster

FEBS Open Bio, EarlyView.
Under environmental changes, the expression level of neuropeptide (NP) and neuropeptide receptor (NPR) genes changes to confer context‐dependent adaptation to the model organism Drosophila melanogaster. Through finding more regulatory elements in the NPR genes in comparison with their ligands (NPs), we found that NPR‐biased transcriptional regulation ...
SeungHeui Ryu, Yanan Wei, Zekun Wu, Tianmu Zhang, DoHoon Lee, Hadi Najafi, Woo Jae Kim   +6 more
wiley   +1 more source