LIGHT ACTIVATION OF THE PLANT ENZYME WHICH OXIDIZES GLYCOLIC ACID
, 1950 N. E. Tolbert, R. H. Burris
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Histochemical Demonstration of Non-specific Esterase in Mast Cells of the Albino Rat with Properties Similar to Mast Cell Enzyme activated in Anaphylaxis [PDF]
, 1962 R. Keller
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Ubiquitination of transcription factors in cancer: unveiling therapeutic potential
Molecular Oncology, EarlyView.In cancer, dysregulated ubiquitination of transcription factors contributes to the uncontrolled growth and survival characteristics of tumors. Tumor suppressors are degraded by aberrant ubiquitination, or oncogenic transcription factors gain stability through ubiquitination, thereby promoting tumorigenesis.
Dongha Kim, Hye Jin Nam, Sung Hee Baek
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The enzymic synthesis of aryl sulphamates. 3. The specificity and mechanism of the activation of rat-Liver arylamine sulphokinase by 17-oxo steroids [PDF]
, 1962 AB Roy
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Targeted protein degradation in oncology: novel therapeutic opportunity for solid tumours?
Molecular Oncology, EarlyView.Current anticancer therapies are limited by the occurrence of resistance and undruggability of most proteins. Targeted protein degraders are novel, promising agents that trigger the selective degradation of previously undruggable proteins through the recruitment of the ubiquitin–proteasome machinery. Their mechanism of action raises exciting challenges,
Noé Herbel, Sophie Postel‐Vinay
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Lipid-induced NOX2 activation inhibits autophagic flux by impairing lysosomal enzyme activity[S]
Journal of Lipid Research, 2015 Autophagy is a catabolic process involved in maintaining energy and organelle homeostasis. The relationship between obesity and the regulation of autophagy is cell type specific.
Bharat Jaishy +9 more
doaj
Determination of ADP/ATP translocase isoform ratios in malignancy and cellular senescence
Molecular Oncology, EarlyView.The individual functions of three isoforms exchanging ADP and ATP (ADP/ATP translocases; ANTs) on the mitochondrial membrane remain unclear. We developed a method for quantitatively differentiating highly similar human ANT1, ANT2, and ANT3 using parallel reaction monitoring. This method allowed us to assess changes in translocase levels during cellular
Zuzana Liblova +18 more
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SERINE AND THREONINE DEAMINASES OF ESCHERICHIA COLI: ACTIVATORS FOR A CELL-FREE ENZYME
, 1949 W.A. Wood, I. C. Gunsalus
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Mechanism-based sirtuin enzyme activation
bioRxiv, 2015 X. Guan +3 more
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Molecular Oncology, EarlyView.Breast cancer metastasis is associated with myeloid cell dysregulation and the lung‐specific accumulation of tumor‐supportive Gr1+ cells. Gr1+ cells support metastasis, in part, through a CHI3L1‐mediated mechanism, which can be targeted and inhibited with cargo‐free, polymeric nanoparticles.
Jeffrey A. Ma +9 more
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