Results 131 to 140 of about 103,401 (316)

Methadone Induces the Expression of Hepatic Drug-Metabolizing Enzymes through the Activation of Pregnane X Receptor and Constitutive Androstane Receptor [PDF]

, 2009
Antonia H. Tolson, Haishan Li, Natalie D. Eddington, Hongbing Wang   +3 more
openalex   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

STUDY THE EFFECT OF ADENOSINE DEAMINASE ENZYME IN INDUCES CYTOGENETIC AND HISTOPATHOLOGICAL CHANGES IN RATS SKIN AND EYES TREATED WITH SUMICIDIN

, 2000
Bushra Ibrahim Al-Qaisi
openalex   +2 more sources

Human Cytomegalovirus Induces the Activity and Expression of Acetyl-Coenzyme A Carboxylase, a Fatty Acid Biosynthetic Enzyme Whose Inhibition Attenuates Viral Replication

, 2020
C. M. Spencer, X. L. Schafer, N. J. Moorman, J. Munger   +3 more
openalex   +1 more source

Supplementary Figure 6 from The Nedd8-Activating Enzyme Inhibitor MLN4924 Thwarts Microenvironment-Driven NF-κB Activation and Induces Apoptosis in Chronic Lymphocytic Leukemia B Cells [PDF]

, 2023
J. Claire Godbersen, Leigh Ann Humphries, Olga V. Danilova, Peter E. Kebbekus, Jennifer R. Brown, Alan Eastman, Alexey V. Danilov   +6 more
openalex   +1 more source

Cotargeting TREM2 and IL2 pathways triggers multipronged anticancer immunity

Molecular Oncology, EarlyView.
Von Locquenghien et al. report that MiTE‐144, a triggering receptor expressed on myeloid cells 2 (TREM2) blocking antibody fused to interleukin‐2 (IL2) variant with tumour microenvironment restricted activation, demonstrates superior anticancer efficiency in a preclinical setting.
Isaure Vanmeerbeek, Jenny Sprooten, Abhishek D. Garg   +2 more
wiley   +1 more source

Review of: "Cadmium Toxicity Induced Changes on Antioxidative Enzymes Level in Fresh Water Catfish Channa Punctatus (Bloch)" [PDF]

Ibrahim Mohamed
openalex   +1 more source

Allosteric transitions of rabbit skeletal muscle lactate dehydrogenase induced by pH-dependent dissociation of the tetrameric enzyme

, 2022
L.G. Iacovino, Martina Rossi, Giuseppina Di Stefano, Valentina Rossi, Claudia Binda, Maurizio Brigotti, Fabio Tomaselli, Alberto Pietro Pasti, Fabrizio Dal Piaz, Stefano Cerini, Alejandro Hochkoeppler   +10 more
openalex   +2 more sources

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Detoxication enzyme inducers modify cytokine production in rat mixed glial cells

, 2005
Anne Wierinckx, John J. P. Brevé, Dominique Mercier, Marianne Schultzberg, Benjamin Drukarch, Anne‐Marie van Dam   +5 more
openalex   +2 more sources