Results 171 to 180 of about 103,401 (316)

How conformational changes can affect catalysis, inhibition and drug resistance of enzymes with induced-fit binding mechanism such as the HIV-1 protease [PDF]

, 2013
Thomas R. Weikl, Bahram Hemmateenejad
openalex   +1 more source

Confusion surrounding liver enzyme-inducing drugs [PDF]

Journal of Family Planning and Reproductive Health Care, 2005
openaire   +2 more sources

Domain associated with zinc fingers‐containing NF90‐NF45 complex inhibits m6A modification of primary microRNA by suppressing METTL3/14 activity

FEBS Open Bio, EarlyView.
NF90–NF45 functions as a negative regulator of methyltransferase‐like 3/14 (METTL3/14)‐mediated N6‐methyladenosine (m6A) modification on primary microRNAs (pri‐miRNAs). NF90–NF45 binds to anti‐oncogenic pri‐miRNAs and inhibits their m6A modification, thereby suppressing the biogenesis of anti‐oncogenic miRNAs.
Takuma Higuchi, Shunsuke Morioka, Keiko Morisawa, Kazutsugu Matsukawa, Shingo Ashida, Takeshi Suzuki, Shuji Sakamoto   +6 more
wiley   +1 more source

IGFBP2 Is Overexpressed by Pediatric Malignant Astrocytomas and Induces the Repair Enzyme DNA-PK

, 2008
Oren J. Becher, Katia M. Peterson, Soumen Khatua, Maria Rita Santi, Tobey J. MacDonald   +4 more
openalex   +2 more sources

Warfarin Interaction With Hepatic Cytochrome P-450 Enzyme-Inducing Anticonvulsants [PDF]

, 2017
Nathan P. Clark, Kim Hoang, Thomas Delate, John R. Horn, Daniel M. Witt   +4 more
openalex   +1 more source

Pioglitazone plus (−)‐epigallocatechin gallate: a novel approach to enhance osteogenic performance in aged bone marrow mesenchymal stem cells

FEBS Open Bio, EarlyView.
Aged human bmMSCs are seeded in the scaffold. Osteoblastic induction can slightly increase cell's bone‐forming activity to produce bone‐like tissues, shown as the sporadic xylenol orange‐stained spots (the lower left image). Notably, pioglitazone plus EGCG co‐treatment dramatically increases cell's bone‐forming activity and bone‐like tissue production (
Ching‐Yun Chen, Jia‐Ci Jhang, Chun‐Yi Peng, Quốc Cường Nguyễn, Feng‐Huei Lin, Hung‐Ming Wu, Shankung Lin   +6 more
wiley   +1 more source

A drug-drug interaction study to evaluate the effects of strong CYP3A4 inducer on the pharmacokinetics of segesterone acetate and ethinyl estradiol in a contraceptive vaginal system. [PDF]

Contracept Reprod Med
Plagianos M, Lansiaux M, Kumar N, Graham S, Sussman H, Kushner H, Creasy G, Bernick B, Haddad LB.   +8 more
europepmc   +1 more source

AN INDUCIBLE ENZYME SYSTEM IN THE LARVAL CELLS OF DROSOPHILA MELANOGASTER [PDF]

, 1963
T. M. Rizki, Rose M. Rizki
openalex   +1 more source

Herpesvirus-induced enzymes and their inhibitors.

Uirusu, 1987
openaire   +3 more sources

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source