Results 91 to 100 of about 2,177,587 (253)
Potentiation of bradykinin actions by angiotensin I converting enzyme inhibitors.
, 1997 Potentiation of bradykinin actions by angiotensin I converting enzyme ...
Richard Dale. Minshall (7969961)
core +3 more sources
New Tacrine−Huperzine A Hybrids (Huprines): Highly Potent Tight-Binding Acetylcholinesterase Inhibitors of Interest for the Treatment of Alzheimer's Disease [PDF]
, 2000 Several new 12-amino-6,7,10,11-tetrahydro-7,11-methanocycloocta[b]quinoline derivatives (tacrine−huperzine A hybrids, huprines) have been synthesized and tested as acetylcholinesterase (AChE) inhibitors.
Badia, Albert +9 more
core +1 more source
Unlocking the potential of cell‐permeable nanobodies for intracellular applications
FEBS Letters, EarlyView.This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés +2 more
wiley +1 more source
ChemistryEuropeCobalt‐corrins, such as coenzyme B12 (AdoCbl) and methylcobalamin (MeCbl), are indispensable enzyme‐cofactors found across all kingdoms of life. Their Rh‐homologues are promising coordination‐chemical and structural B12‐mimics. Herein, the preparation of
Florian J. Widner +8 more
doaj +1 more source
Dual antidiabetic and anticancer potential of Melia dubia seed extract: An integrated in silico and in vitro study [PDF]
Journal of HerbMed PharmacologyIntroduction: Melia dubia seeds are traditionally used against diabetes mellitus and cancer. Molecular docking studies were performed to evaluate the binding affinity of major compounds against α-glucosidase and the mechanistic target of rapamycin (mTOR),
Manasa Gopal +5 more
doaj +1 more source
Outline of enzyme inhibitors employed in the experiments.
, 2013 Outline of enzyme inhibitors employed in the experiments.
Jasmina Varagic (337541) +5 more
core +1 more source
New inhibitors of bacterial hyaluronidase - synthesis and structure-activity relationships [PDF]
, 2006 Potent and selective inhibitors of hyaluronidases are not reported in the literature so far. Such compounds are required as pharmacological tools to investigate the physiological and pathophysiological role of the enzymes and their preferred substrate ...
Braun, Stephan
core +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Natural Inhibitors of the Aromatase Enzyme
Molecules, 2000 The results of three years of search for natural aromatase inhibitors will be presented.
Roberto R. Gil
doaj +1 more source