Results 171 to 180 of about 700,443 (307)

Comparative Effectiveness of Angiotensin-Converting Enzyme Inhibitors Versus Angiotensin Receptor Blockers: Multidatabase Target Trial Emulation Studies. [PDF]

Hypertension
Xie C, Chen R, Zhou S, Lin Y, Liu J, Su L, Pang M, Guo Z, Luo F, Chen L, Kong Y, Nie S.   +11 more
europepmc   +1 more source

Angiotensin-Converting Enzyme Inhibitors and Other Medications Associated With Angioedema. [PDF]

Cureus, 2023
Landry L, Witten T, Anwar AI, Jackson CN, Talbot NC, Ahmadzadeh S, Varrassi G, Shekoohi S, Kaye AD.   +8 more
europepmc   +1 more source

HSP70 governs permeability and mechanotransduction in primary human endothelial cells

FEBS Open Bio, EarlyView.
HSP70 chemical inhibition reduces endothelial cell proliferation and increases permeability, the latter supported by normal interendothelial junctional protein distribution. HSP70 also plays a role in shear stress response, a hemodynamic force naturally present in blood vessels and correlated with vessel protection.
Andrea Pinto‐Martinez, Everton G. Melo, Isadora C. B. Pavan, Percíllia V. S. Oliveira, Luiza B. C. T. Coimbra, Thaís L. S. Araujo   +5 more
wiley   +1 more source

First comprehensive compositional analysis of E. arborescens leaves with new insights into their potential as enzyme inhibitors. [PDF]

Sci Rep
Ayda T, Hanen G, Zouhaier N, Slim C.
europepmc   +1 more source

A Structural and In Silico Investigation of Potential CDC7 Kinase Enzyme Inhibitors. [PDF]

ACS Omega, 2023
Mookkan M, Kandasamy S, Al-Odayni AB, Abduh NAY, Srinivasan S, Revannasidappa BC, Kumar V, Chinnasamy K, Aravindhan S, Shankar MK.   +9 more
europepmc   +1 more source

Cloning, expression, purification, and structural modeling of the Chandipura virus matrix protein

FEBS Open Bio, EarlyView.
This research protocol offers a guide for the cloning, expression, and purification of the Chandipura virus matrix protein using E. coli. It also includes a step‐by‐step procedure for cloning, expressing, and conducting fluorescence imaging of GFP‐fused Chandipura virus matrix protein in mammalian cell lines.
Mariana Grieben
wiley   +1 more source

The Role of Phosphodiesterase-5 Enzyme Inhibitors and Prostacyclin Analogs in Reactive Pulmonary Vasculopathy in Systolic Heart Failure: A Narrative Review. [PDF]

Cureus
Sekharamahanti HE, Patel DV, Prajapati M, Sirekulam V, Shah P, Peracha HT, Patel S, Makineni KS, Anene JI, Harish R, Mansfield AM.   +10 more
europepmc   +1 more source

Thrombolytic proteins profiling: High‐throughput activity, selectivity, and resistance assays

FEBS Open Bio, EarlyView.
We present optimized biochemical protocols for evaluating thrombolytic proteins, enabling rapid and robust screening of enzymatic activity, inhibition resistance, and fibrin affinity, stimulation, and selectivity. The outcome translates to key clinical indicators such as biological half‐life and bleeding risk. These assays streamline the development of
Martin Toul, Alan Strunga, Jiri Damborsky, Zbynek Prokop   +3 more
wiley   +1 more source

Screening for dual-target enzyme inhibitors derived from <i>Gardenia jasminoides</i> roots, a medicinal and edible plant: investigation of their potential anti-dementia activity. [PDF]

Front Nutr
Liu X, Zhou Y, Meng R, Han J, Chen M, Bo X, Li S, Song D, Zhang Y.   +8 more
europepmc   +1 more source

Fluoride-Mediated Capture of a Noncovalent Bound State of a Reversible Covalent Enzyme Inhibitor: X-ray Crystallographic Analysis of an Exceptionally Potent α-Ketoheterocycle Inhibitor of Fatty Acid Amide Hydrolase

, 2011
Mauro Mileni, Joie Garfunkle, Cyrine Ezzili, Benjamin F. Cravatt, Raymond C. Stevens, Dale L. Boger   +5 more
openalex   +2 more sources