Results 181 to 190 of about 700,443 (307)

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Utilization and Dose Optimization of Angiotensin-Converting Enzyme Inhibitors in Heart Failure Patients With Reduced Ejection Fraction: A Cross Sectional Study on Implications for Guideline-Targeted Therapy. [PDF]

Health Sci Rep
Kampamba M, Mbanvu R, Hangoma J, Mwalungali G, Mutenda M, Hamachila A.   +5 more
europepmc   +1 more source

Enzyme Inhibitors [PDF]

Nature, 1967
openaire   +1 more source

In silico design of enzyme α-amylase and α-glucosidase inhibitors using molecular docking, molecular dynamic, conceptual DFT investigation and pharmacophore modelling

, 2021
Hadjer Chenafa, Fouzia Mesli, Ismail Daoud, Radja Achiri, Saïd Ghalem, Abdelhak Neghra   +5 more
openalex   +2 more sources

Molecular determinants of signal transduction in tropomyosin receptor kinases

FEBS Open Bio, EarlyView.
Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley   +1 more source

Special Issue: "Enzymes and Enzyme Inhibitors-Applications in Medicine and Diagnosis 2.0". [PDF]

Int J Mol Sci
Geronikaki A.
europepmc   +1 more source

Perindopril - angiotensin-converting enzyme inhibitor is approved for usage

, 2014
Д. А. Напалков
openalex   +1 more source

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source

Angiotensin-Converting Enzyme Inhibitors Mitigate Development of Chronic Persistent Cardiac Dysfunction Following Fulminant Myocarditis: A Multicenter Retrospective Study in China. [PDF]

Int J Gen Med
Yang H, Qidamugai W, Wang L, Liu F, He Y, Xu Z, Zhang L, Li F, Wang H, Jiang J.   +9 more
europepmc   +1 more source

OF4949, new inhibitors of aminopeptidase A. IV Effects of OF4949 and its derivatives on enzyme systems.

, 1987
Susumu Sano, KATSUSHIGE IKAI, Yoshie Yoshikawa, Teruya Nakamura, Akira Ôbayashi   +4 more
openalex   +2 more sources