Results 251 to 260 of about 5,417,177 (410)

Neurotoxic amyloid β‐peptide and tau produce cytokine‐like effects on PMCA in glioblastoma cell lines, enhancing its activity and isoforms expression

FEBS Open Bio, EarlyView.
Two biomarkers of Alzheimer's disease, amyloid β‐peptide (Aβ) and tau, induce the transformation of U‐251 and other glioblastoma cell lines into neurotoxic A1‐like reactive astrocytes. This transformation is produced by cytokines and is followed by upregulation of PMCA activity and isoform expression, and is closely associated with inflammation, as ...
María Berrocal, Alberto Alvarez‐Barrientos, Ana M. Mata   +2 more
wiley   +1 more source

Demystifying Functional Parameters for Irreversible Enzyme Inhibitors. [PDF]

J Med Chem
Heppner DE, Ogboo BC, Urul DA, May EW, Schaefer EM, Murkin AS, Gehringer M.   +6 more
europepmc   +1 more source

Impact of angiotensin-converting enzyme inhibitors or angiotensin receptor blockers on the mortality in sepsis: A meta-analysis. [PDF]

World J Clin Cases, 2023
Yang DC, Xu J, Jian L, Yu Y.
europepmc   +1 more source

EFFECTS OF ENZYME INHIBITORS ON JUNCTION POTENTIALS IN RESPONSE TO ADRENERGIC NERVE STIMULATION

, 1969
Hironori Nakanishi, Masami Doteuchi, Koichi Otani, Hideo Tanaka, Hiroshi Takeda   +4 more
openalex   +1 more source

Boundaries of photosynthesis: adaptations of carbon fixation in extreme environments

FEBS Open Bio, EarlyView.
Photosynthesis faces challenges from environmental extremes of temperature, pH, and salinity, limiting gas diffusion, modifying membrane fluidity, and destabilizing photochemical and biochemical reactions. Photosynthetic organisms have evolved unique adaptations overcoming these stresses and maintaining their photosynthetic activity.
Pere Aguiló‐Nicolau, Concepción Iñiguez, Sebastià Capó‐Bauçà, Jeroni Galmés   +3 more
wiley   +1 more source

Whole Exome Sequencing in Drug-Induced Angioedema Caused by Angiotensin-Converting Enzyme Inhibitors: A Pilot Study in Five Patients. [PDF]

J Clin Med
Mendoza-Alvarez A, Martinez-Tadeo JA, Perez-Rodríguez E, Barrios-Recio J, García-Robaina JC, Corrales A, Marcelino-Rodríguez I, Lorenzo-Salazar JM, González-Montelongo R, Flores C, Callero A.   +10 more
europepmc   +1 more source

Microorganism-Derived Molecules as Enzyme Inhibitors to Target Alzheimer's Diseases Pathways. [PDF]

Pharmaceuticals (Basel), 2023
Nguyen TH, Wang SL, Nguyen VB.
europepmc   +1 more source

Characterization of a proteolytic-enzyme inhibitor with allergenic activity. Multiple functions of a parasite-derived protein [PDF]

, 1979
Peter Willadsen, George Riding
openalex   +1 more source

The impact of frailty syndrome on skeletal muscle histology: preventive effects of exercise

FEBS Open Bio, EarlyView.
Frailty syndrome exacerbates skeletal muscle degeneration via increased ECM deposition and myofiber loss. This study, using a murine model, demonstrates that endurance exercise attenuates these histopathological alterations, preserving muscle integrity. Findings support exercise as a viable strategy to counteract frailty‐induced musculoskeletal decline
Fujue Ji, Hae Sung Lee, Haesung Lee, Jong‐Hee Kim   +3 more
wiley   +1 more source

Epigenetic drug screening identifies enzyme inhibitors A-196 and TMP-269 as novel regulators of sprouting angiogenesis. [PDF]

Sci Rep
Beter M, Pulkkinen HH, Örd T, Sormunen A, Kilpeläinen L, Dunford JE, Kaikkonen MU, Aavik E, Laham-Karam N, Oppermann U, Laakkonen JP, Ylä-Herttuala S.   +11 more
europepmc   +1 more source