Results 291 to 300 of about 5,024,684 (342)

Angiotensin-Converting Enzyme Inhibitors

Journal of Hypertension, 1991
The introduction of angiotensin-converting enzyme (ACE) inhibitors for the treatment of hypertension and heart failure is probably the most important advance in cardiovascular pharmacotherapy in the last few decades. Although the role of the renin-angiotensin system (RAS) in cardiovascular diseases had been investigated extensively for more than 70 yr,
Irene Gavras, Haralambos Gavras
openaire   +2 more sources

A strategy for screening of high-quality enzyme inhibitors from herbal medicines based on ultrafiltration LC-MS and in silico molecular docking.

Chemical Communications, 2015
A novel strategy of ultrafiltration LC-MS and in silico molecular docking was proposed to discover high-quality enzyme inhibitors from herbal medicines. Using this strategy, two compounds were predicted and finally demonstrated as potent xanthine oxidase
Hui-peng Song, Jun Chen, Jia-Ying Hong, H. Hao, L. Qi, Jun Lu, Yu Fu, Binluo Wu, Hua Yang, Ping Li   +9 more
semanticscholar   +1 more source

Enzyme kinetics in relation to enzyme inhibitors

Biochemical Pharmacology, 1973
Abstract A Large number of pharmacologically important compounds have been found to act as enzyme inhibitors and a kinetic study of the inhibitory process can provide important information on the potency of the compound and on its mode of interaction with the enzyme.
openaire   +3 more sources

Inhibitors of Kinin-Forming Enzymes

Agents and Actions, 1976
The typical trypsin-like protease in animals were plasmin, kallikrein, thrombin, factor X, XI, XII, cathepsin B, plasminogen tissue activator and urokinase, and so on. Among them plasmin and kallikrein have kinin-forming activity. A synthetic reversible inhibitor of plasmin, and anticoagulant factor of blood, has been extensively studied.
openaire   +4 more sources

Overview of Randomized Trials of Angiotensin-Converting Enzyme Inhibitors on Mortality and Morbidity in Patients With Heart Failure

, 1995
Objective. —To evaluate the effect of angiotensin-converting enzyme (ACE) inhibitors on mortality and morbidity in patients with symptomatic congestive heart failure. Data Sources and Study Selection.
R. Garg, S. Yusuf
semanticscholar   +1 more source

Boronic acid-based enzyme inhibitors: a review of recent progress.

Current Medicinal Chemistry, 2014
Since Bortezomib was approved by US FDA as the first drug to treat multiple myeloma, various boronic acid compounds have been developed as enzyme inhibitors.
H. Fu, Hao Fang, Jie Sun, H. Wang, A. Liu, J. Sun, Z. Wu   +6 more
semanticscholar   +1 more source

A classification of enzyme inhibitors

Bioorganic & Medicinal Chemistry Letters, 1992
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
openaire   +3 more sources

Thiosemicarbazones as inhibitors of tyrosinase enzyme

Bioorganic & Medicinal Chemistry Letters, 2017
In the search for compounds which may inhibit the development of melanomas, a series of thiosemicarbazones has been investigated as possible inhibitors of the tyrosinase enzyme. The results showed that all the thiosemicarbazones tested exhibited significant inhibitory effects on the enzyme.
Mariana A. Soares, Carla Marins-Goulart, Aurea Echevarria, Otávio Augusto Chaves, Mariana A. Almeida, Márcia C.C. de Oliveira   +5 more
openaire   +3 more sources

Preparation of a dual-enzyme co-immobilized capillary microreactor and simultaneous screening of multiple enzyme inhibitors by capillary electrophoresis.

Journal of Separation Science, 2013
A CE method based on a dual-enzyme co-immobilized capillary microreactor was developed for the simultaneous screening of multiple enzyme inhibitors. The capillary microreactor was prepared by co-immobilizing adenosine deaminase and xanthine oxidase on ...
Pingtan Lin, Shulin Zhao, Xin Lu, Fanggui Ye, Hengshan Wang   +4 more
semanticscholar   +1 more source

Enzyme Inhibitors

Medicinal chemistry, 2021
A. K. Ganguly, S. Alluri
semanticscholar   +1 more source