Results 51 to 60 of about 5,417,177 (410)
Impact of angiotensin-converting enzyme inhibitors and statins on viral pneumonia
Proceedings, 2018 Angiotensin-converting enzyme (ACE) inhibitors and statins may potentially benefit patients with viral infections and pneumonia. Our study aimed to evaluate the impact of ACE inhibitors and statins on the rates of intubation and death in viral pneumonia.
Christopher Henry +5 more
semanticscholar +1 more source
Inhibitors of sphingolipid metabolism enzymes
Biochimica et Biophysica Acta (BBA) - Biomembranes, 2006 Sphingolipids are a family of lipids that play essential roles both as structural cell membrane components and in cell signalling. The cellular contents of the various sphingolipid species are controlled by enzymes involved in their metabolic pathways. In this context, the discovery of small chemical entities able to modify these enzyme activities in a
Delgado Cirilo, Antonio +4 more
openaire +4 more sources
Nepalese Medical Journal, 2020 Angiotensin-converting enzyme-2 receptor has been unearthed as a prime site of entry of Severe Acute Respiratory Syndrome Coronavirus 2 owing to its strong affinity towards spike protein of Severe Acute Respiratory Syndrome Coronavirus 2, resulting in ...
Kunal Bikram Shaha +5 more
doaj +1 more source
Absolute diffusion measurements of active enzyme solutions by NMR [PDF]
, 2018 The diffusion of enzymes is of fundamental importance for many biochemical processes. Enhanced or directed enzyme diffusion can alter the accessibility of substrates and the organization of enzymes within cells. Several studies based on fluorescence correlation spectroscopy (FCS) report enhanced diffusion of enzymes upon interaction with their ...
arxiv +1 more source
Effectiveness of enzyme inhibitors in biomedicine and pharmacotherapy
Advances in Tissue Engineering & Regenerative Medicine Open Access, 2019 Enzymes are incredibly efficient biological catalysts that catalyze all cellular processes.1 However, several studies shed light on the importance of enzyme inhibitors in the pharmaceutical industry.2 The study of enzyme inhibitors has provided valuable ...
A. Ouertani +4 more
semanticscholar +1 more source
Numerical calculation of protein-ligand binding rates through solution of the Smoluchowski equation using smooth particle hydrodynamics [PDF]
BMC Biophys. 2015; 8: 7, 2015 Background. The calculation of diffusion-controlled ligand binding rates is important for understanding enzyme mechanisms as well as designing enzyme inhibitors. We demonstrate the accuracy and effectiveness of a Lagrangian particle-based method, smoothed particle hydrodynamics (SPH), to study diffusion in biomolecular systems by numerically solving ...
arxiv +1 more source
Kinetic modelling of in vitro data of PI3K, mTOR1, PTEN enzymes and on-target inhibitors Rapamycin, BEZ235, and LY294002 [PDF]
, 2016 The phosphatidylinositide 3-kinases (PI3K) and mammalian target of rapamycin-1 (mTOR1) are two key targets for anti-cancer therapy. Predicting the response of the PI3K/AKT/mTOR1 signalling pathway to targeted therapy is made difficult because of network ...
Bown, James L. +4 more
core +3 more sources
, 2018 Xiong G.-Y., Zhang L.-L., Zhang W., Wu J. (2012): Influence of ultrasound and proteolytic enzyme inhibitors on muscle degradation, tenderness, and cooking loss of hens during aging. Czech J. Food Sci., 30: 195–205.
G. Xiong +3 more
semanticscholar +1 more source
Zanco Journal of Medical Sciences, 2020 Genetic variations between individuals usually leads to differences in the drug response as it could affect both pharmacokinetic and pharmacodynamic processes. An example of mutation of genes that affect drug targets (pharmacodynamic) is VKORC1 gene that
Rojgar Hamed Ali
doaj +1 more source
Marine Drugs, 2023 Proteolytic enzymes, also known as peptidases, are critical in all living organisms. Peptidases control the cleavage, activation, turnover, and synthesis of proteins and regulate many biochemical and physiological processes.
Isel Pascual Alonso +8 more
doaj +1 more source