Results 61 to 70 of about 5,024,684 (342)
Molecules, 2020 Peptidyl enzyme inhibitors containing an internal aminomethylphosphinic bond system (P(O)(OH)-CH2-NH) can be termed extended transition state analogs by similarity to the corresponding phosphonamidates (P(O)(OH)-NH).
Kamila Janiszewska +5 more
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Natural Products as a Potential Enzyme Inhibitors from Medicinal Plants
, 2017 Enzyme inhibitory agents are attractive because of their application in treating different ailments. The absence of enzymes produce a number of diseases.
A. Rauf, N. Jehan
semanticscholar +1 more source
Therapy of endocrine disease: steroidogenesis enzyme inhibitors in Cushing's syndrome.
European Journal of Endocrinology, 2015 Steroidogenesis enzyme inhibitors are the mainstay of medical therapy in Cushing's syndrome (CS). Ketoconazole (KTZ) and metyrapone are the most commonly used agents. Although there is considerable experience of their use in individual specialist centres,
Eleni Daniel, J. Newell-Price
semanticscholar +1 more source
Renin–Angiotensin–Aldosterone System Inhibitors in Patients with Covid-19
New England Journal of Medicine, 2020 RAAS Inhibitors in Patients with Covid-19 The effects of renin–angiotensin–aldosterone system blockers on angiotensin-converting enzyme 2 levels and activity in humans are uncertain.
M. Vaduganathan +5 more
semanticscholar +1 more source
A stepwise emergence of evolution in the RNA world
FEBS Letters, EarlyView.How did biological evolution emerge from chemical reactions? This perspective proposes a gradual scenario of self‐organization among RNA molecules, where catalytic feedback on random mixtures plays the central role. Short oligomers cross‐ligate, and self‐assembly enables heritable variations. An event of template‐externalization marks the transition to
Philippe Nghe
wiley +1 more source
Angiotensin-converting enzyme inhibitors
Revista Cubana de Cardiología y Cirugía Cardiovascular, 2014 In an updated review concerning the angiotensin-converting enzyme inhibitors, an account of the historical development of this group of drugs proved as highly effective in the treatment of hypertension and of congestive heart failure is made.
David García Barreto +1 more
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Metal- and Semimetal-Containing Inhibitors of Thioredoxin Reductase as Anticancer Agents
Molecules, 2015 The mammalian thioredoxin reductases (TrxRs) are a family of selenium-containing pyridine nucleotide disulfide oxidoreductases playing a central role in cellular redox homeostasis and signaling pathways.
Valentina Gandin, Aristi P. Fernandes
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FEBS Letters, EarlyView.The enzyme 5‐lipoxygenase (5‐LOX) catalyzes the first step in the biosynthesis of leukotrienes (LTs) involved in inflammatory pathophysiology. After cellular stimulation, 5‐LOX translocates to the nucleus, interacting with the 5‐LOX‐activating protein (FLAP) to form LTA4 from arachidonic acid (AA).
Erik Romp +5 more
wiley +1 more source
FEBS Letters, EarlyView.B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro +2 more
wiley +1 more source
Immobilized enzyme reactors in HPLC and its application in inhibitor screening: A review
Journal of Pharmaceutical Analysis, 2012 This paper sets out to summarize the literatures based on immobilized enzyme bio-chromatography and its application in inhibitors screening in the last decade.
Si-Meng Fang +3 more
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