Results 121 to 130 of about 3,952,882 (246)

Anti‐Inflammatory and Neuroactive Effects of Polymer‐Coated Iron Oxide Nanoparticles Functionalized With Interleukin 4 for Spinal Cord Injury

Advanced Healthcare Materials, EarlyView.
Polymer‐coated IONPs functionalized with IL‐4 display respective neuroactive and anti‐inflammatory actions on neural progenitor cells and macrophages/microglia in vitro. When examined chronically in a rat experimental model of spinal cord injury, rGO scaffolds carrying these nanosystems adequately integrate into the lesion, significantly reduce ...
Julia Martínez‐Ramírez, Paloma Lozano‐Picazo, María de Lamo‐Atencia, Andrea Ferreras, Esther Benayas‐Martín, Elena Fernández‐López, Marina Sánchez‐Petidier, Verónica Barranco‐Maresca, Víctor Caz, Anne des Rieux, Juliana M. Rosa, María del Puerto Morales, María C. Serrano   +12 more
wiley   +1 more source

Profile of asfotase alfa in the treatment of hypophosphatasia: design, development, and place in therapy

Drug Design, Development and Therapy, 2018
Sasigarn A Bowden,1 Brian L Foster2 1Division of Endocrinology, Department of Pediatrics, Nationwide Children’s Hospital/The Ohio State University College of Medicine, Columbus, OH 43205, USA; 2Division of Biosciences, College of Dentistry, The ...
Bowden SA, Foster BL
doaj  

Changing Times for CLN2 Disease: The Era of Enzyme Replacement Therapy

, 2020
Nicola Specchio, Nicola Pietrafusa, Marina Trivisano Rare and Complex Epilepsy Unit, Department of Neuroscience, Bambino Gesù Children’s Hospital, IRCCS, Rome, ItalyCorrespondence: Nicola SpecchioDepartment of Neuroscience, Bambino Ges ...
Pietrafusa N, Trivisano M, Specchio N
core  

Topically Delivered Treg‐Attracting Microparticle‐Hydrogel Composites Recruit Regulatory T Cells and Limit Cardiac Injury After Severe Ischemia

Advanced Healthcare Materials, EarlyView.
CCL22‐releasing PLGA microparticles (MP) suspended in topically applied hydrogels (HEART) establish a sustained chemokine gradient at the injured myocardium. HEART recruits CCR4+ regulatory T cells, reduces infarct size and graft fibrosis, and improves cardiac function.
Matthew A. Borrelli, Alexis T. Reese, Jordan J. P. Warunek, Betsy Ann Varghese, Canxing Lin, Jeffery J. Baust, Brenda McMahon, Steven R. Little, Hēth R. Turnquist   +8 more
wiley   +1 more source

Clinical course and management of fabry disease in three patients before the introduction of enzyme replacement therapy

Zdravniški Vestnik, 2006
Background: Fabry disease (FD) is an X-linked inherited disorder of glycosphingolipids metabolism. Clinical manifestations, the course and the cause of death are markedly different among the patients. Before the use of enzyme replacement therapy patients
Franc Verovnik
doaj  

A reassessment of the cost-effectiveness of hormone replacement therapy in Sweden – results based on the Women’s Health Initiative randomised controlled trial [PDF]

The cost-effectiveness of hormone replacement therapy (HRT) based on a societal perspective is reassessed based on new medical evidence found in the Women’s Health Initiative (WHI).
Jönsson, Bengt, Borgström, Fredrik, Zethraeus, Niklas, Kanis, John   +3 more
core  

Atom‐Efficient Cerium‐Based Molecular Cages as Biocompatible Reactive Oxygen Scavengers

Advanced Healthcare Materials, EarlyView.
Discrete mixed‐valent cerium molecular cages organize accessible redox centers within confined coordination environments and scavenge superoxide, hydrogen peroxide, and hydroxyl radicals. Encapsulation of the lead cage in an ROS‐responsive DTP nanoplatform enables lesion‐associated delivery, attenuates macrophage oxidative stress and inflammation, and ...
Chao Li, Chunbai Xiang, Ye Xu, Yu Liu, Keze Hong, Fanchu Zeng, Gelin Xu, Zhao‐Xi Wang, Jonathan L. Sessler, Ping Gong   +9 more
wiley   +1 more source

Hemocompatible Glycogen‐Tissue Plasminogen Activator Complexes for Enhanced Blood Clot Dissolution

Advanced Healthcare Materials, EarlyView.
Glycogen–heparin‐cRGD nanoparticles enable targeted delivery of tissue plasminogen activator (tPA) to thrombi through activated platelet recognition. The hemocompatible hybrids minimize interactions with blood and immune cells while retaining enzymatic biodegradability.
Nadiia Davydiuk, Vaidehi Londhe, Susanne Boye, Martin Müller, Carsten Werner, Manfred F. Maitz, Quinn A. Besford   +6 more
wiley   +1 more source

Bone Organoids Across the Development‐to‐Remodeling Continuum: From Tissue Formation to Functional Competence and Translation

Advanced Healthcare Materials, EarlyView.
Mineralization alone does not establish a mature bone organoid. This Review integrates biological foundations, materials design, adaptive remodeling, and translational validation through the development‐to‐remodeling continuum (DRC). By separating biological functions from the evidence supporting them, the framework exposes critical gaps in current ...
Xijie Tang, Haijia Xu, Xiangzhong Liu, Yi Yang, Zhanghua Li   +4 more
wiley   +1 more source

Bioprinted Stiffness‑Tunable Pancreatic Microniches to Decode Early Tumor Initiation Mechanisms

Advanced Healthcare Materials, EarlyView.
Stiffness‐tunable GelMA microniches generated by microvalve bioprinting preserve wild‐type acinar identity while revealing a nonlinear, Kras‐dependent response to matrix mechanics. Intermediate stiffness promotes acinar‐to‐ductal metaplasia and proliferation, defining a permissive mechanical window.
Aurelien Mazet, Charles Handschin, Theo Desigaux, Nathalie Dusserre, Marie‐Laure Stachowicz, Shane Fennell, Malou Lea, Silvia Arcucci, Benoît Thibault, Jean‐Christophe Fricain, Julie Guillermet‐Guibert, Hugo Oliveira   +11 more
wiley   +1 more source