Next‐Generation Bio‐Reducible Lipids Enable Enhanced Vaccine Efficacy in Malaria and Primate Models
Advanced Functional Materials, EarlyView.Structure–activity relationship (SAR) optimization of bio‐reducible ionizable lipids enables the development of highly effective lipid nanoparticle (LNP) mRNA vaccines. Lead LNPs show superior tolerability and antibody responses in rodents and primates, outperforming approved COVID‐19 vaccine lipids.
Ruben De Coen +30 more
wiley +1 more source
Intrathecal enzyme replacement therapy reverses cognitive decline in mucopolysaccharidosis type I
, 2017 Igor Nestrašil +10 more
openalex +1 more source
Fabry disease in female patients: clinical features, outcomes and indications for enzyme replacement therapy [PDF]
, 2023 Sergey Moiseev +6 more
openalex +1 more source
DENTA: A Dual Enzymatic Nanoagent for Self‐Activating Tooth Whitening and Biofilm Disruption
Advanced Functional Materials, EarlyView.The nanoapatite with dual enzymes (DENTA) accumulates in dentinal tubules, reducing hypersensitivity caused by dental nerve exposure and facilitating continuous ROS generation through salivary glucose for effective, long‐term whitening. The dentin structures remain non‐destructive due to the low concentration of ROS, demonstrating excellent cell ...
Junseok Kim +13 more
wiley +1 more source
Enzyme replacement therapy with galsulfase for mucopolysaccharidosis type VI
, 2016 M.J. Brunelli +2 more
openalex +2 more sources
Implementation of Drug‐Induced Rhabdomyolysis and Acute Kidney Injury in Microphysiological System
Advanced Functional Materials, EarlyView.A modular Muscle–Kidney proximal tubule‐on‐a‐chip integrates 3D skeletal muscle and renal proximal tubule tissues to model drug‐induced rhabdomyolysis and acute kidney injury. The coculture system enables dynamic tissue interaction, functional contraction monitoring, and quantification of nephrotoxicity, revealing drug side effect‐induced metabolic ...
Jaesang Kim +4 more
wiley +1 more source
Detection of Antibodies That Neutralize the Cellular Uptake of Enzyme Replacement Therapies with a Cell-based Assay [PDF]
, 2018 Ruby Cheung +4 more
openalex +1 more source
Model for Quantitative Evaluation of Enzyme Replacement Treatment [PDF]
, 2009 Gaucher disease is the most frequent lysosomal disorder. Its enzyme replacement treatment was the new progress of modern biotechnology, successfully used in the last years.
Radeva B.
core
Advanced Functional Materials, EarlyView.Bio‐based and (semi‐)synthetic zwitterion‐modified novel materials and fully synthetic next‐generation alternatives show the importance of material design for different biomedical applications. The zwitterionic character affects the physiochemical behavior of the material and deepens the understanding of chemical interaction mechanisms within the ...
Theresa M. Lutz +3 more
wiley +1 more source