Results 131 to 140 of about 2,217,916 (339)

A Microfluidic Multiplex Sorter for Strain Development

Advanced Materials Technologies, Volume 10, Issue 6, March 18, 2025.
A new multiplex method for high‐throughput screening of yeast strains based on glucoamylase production is presented. Droplets containing single mutant yeast cells are incubated for enzyme production. A sorting platform divides mutants by their high‐ and mid‐activity levels.
Chiara Leal‐Alves, Sebastien Dumont, Zhiyang Deng, Sarah Alkhaldi, Ziuwin Leung, Michelle Oeser, Steve C. C. Shih   +6 more
wiley   +1 more source

Geminivirus C2 protein represses genes involved in sulphur assimilation and this effect can be counteracted by jasmonate treatment [PDF]

, 2012
Geminiviruses are plant viruses that infect a broad range of crops and cause extensive losses worldwide, having an important economic impact. C2, a multifunctional pathogenicity factor encoded by geminiviruses, has been recently shown to suppress the ...
Balzergue, Sandrine, Bejarano, Eduardo R., García Domínguez, Irene, Huguet, Stéphanie, Lozano Durán, Rosa, Romero González, Luis Carlos   +5 more
core   +3 more sources

Self‐Adjusting Engineered Probiotic for Targeted Tumor Colonization and Local Therapeutics Delivery

Advanced Science, EarlyView.
Zou et al. developed an engineered strain of Escherichia coli Nissle 1917 with precise targeting abilities for colonization and on‐demand payload release. The engineered probiotic survives and embolizes tumors only in the presence of more than 5 mM L‐lactate. Furthermore, the introduction of an α‐hemolysin circuit enhances its anti‐tumor effect.
Zhen‐Ping Zou, Xin‐Ge Wang, Xuan‐Ren Shi, Shu‐Ting Sun, Jing Mi, Xiao‐Peng Zhang, Bin‐Cheng Yin, Ying Zhou, Bang‐Ce Ye   +8 more
wiley   +1 more source

Modeling stochastic gene expression under repression [PDF]

arXiv, 2005
Intrinsic transcriptional noise induced by operator fluctuations is investigated with a simple spin like stochastic model. The effects of transcriptional fluctuations in protein synthesis is probed by coupling transcription and translation by an amplificative interaction.
arxiv  

Apoptotic Vesicles Derived from Mesenchymal Stem Cells Ameliorate Hypersensitivity Responses via Inducing CD8+ T Cells Apoptosis with Calcium Overload and Mitochondrial Dysfunction

Advanced Science, EarlyView.
The therapeutic potential of ApoVs derived from stem cells from human exfoliated deciduous teeth (SHED‐ApoVs) in the treatment of CD8+ T cell‐mediated hypersensitivity reactions is noteworthy. SHED‐ApoVs are capable of fusing with the plasma membrane of CD8+ T cells, which subsequently triggers a series of events characterized by calcium overload ...
Anqi Liu, Peng Peng, Changze Wei, Fanhui Meng, Xiaoyao Huang, Peisheng Liu, Siyuan Fan, Xinyue Cai, Meiling Wu, Zilin Xuan, Qing Liu, Xinyu Qiu, Zhenlai Zhu, Hao Guo   +13 more
wiley   +1 more source

L-Rhamnose induction of Aspergillus nidulans α-L-rhamnosidase genes is glucose repressed via a CreA-independent mechanism acting at the level of inducer uptake

Microbial Cell Factories, 2012
Background Little is known about the structure and regulation of fungal α-L-rhamnosidase genes despite increasing interest in the biotechnological potential of the enzymes that they encode.
Tamayo-Ramos Juan A, Flipphi Michel, Pardo Ester, Manzanares Paloma, Orejas Margarita   +4 more
doaj   +1 more source

RONIN/HCF1‐TFEB Axis Protects Against D‐Galactose‐Induced Cochlear Hair Cell Senescence Through Autophagy Activation

Advanced Science, EarlyView.
D‐galactose (D‐gal) induced inner ear hair cell senescence by inhibiting TFEB transcription. RONIN/HCF1 promotes TFEB transcription to prevent cochlear HCs from D‐gal‐induced senescence through autophagy activation. Abstract Age‐related hearing loss is characterized by senescent inner ear hair cells (HCs) and reduced autophagy.
Yongjie Wei, Yuhua Zhang, Wei Cao, Nan Cheng, Yun Xiao, Yongjun Zhu, Yan Xu, Lei Zhang, Lingna Guo, Jun Song, Su‐hua Sha, Buwei Shao, Fang Ma, Jingwen Yang, Zheng Ying, Zuhong He, Renjie Chai, Qiaojun Fang, Jianming Yang   +18 more
wiley   +1 more source

Carbon Catabolite Repressor UvCreA is Required for Development and Pathogenicity in Ustilaginoidea virens

Rice Science
The rice false smut disease, caused by Ustilaginoidea virens, has emerged as a significant global threat to rice production. The mechanism of carbon catabolite repression plays a crucial role in the efficient utilization of carbon nutrients and enzyme ...
Xie Shuwei, Shi Huanbin, Wen Hui, Liu Zhiquan, Qiu Jiehua, Jiang Nan, Kou Yanjun   +6 more
doaj  

METTL14‐Mediated M6A Modification of LINC01094 Induces Glucose Metabolic Reprogramming in Breast Cancer by Recruiting the PKM2/JMJD5 Complex

Advanced Science, EarlyView.
METTL14/IGF2BP2‐mediated m6A modification drives LINC01094 upregulation in BC. Then, LINC01094 interacts with PKM2 monomers to promote their dimerization, while serving as a flexible scaffold to facilitate the assembly of the PKM2/JMJD5 complex, synergistically stabilizing PKM2 dimers and enhancing their nuclear translocation.
Mengqi Wang, Zhaoxin Gao, Ruinan Zhao, Pan Zhou, Jingxi Chen, Hui Zhang, Yawen Wang, Wenjie Zhu, Peng Gao   +8 more
wiley   +1 more source

AMP-activated protein kinase activation reduces the transcriptional activity of the murine luteinizing hormone β-subunit gene

The Journal of Reproduction and Development, 2019
Malnutrition is one of the factors that induces reproductive disorders. However, the underlying biological processes are unclear. AMP-activated protein kinase (AMPK) is an enzyme that plays crucial role as a cellular energy sensor.
Ryutaro MORIYAMA, Koichi IWAMOTO, Teruki HAGIWARA, Saishu YOSHIDA, Takako KATO, Yukio KATO   +5 more
doaj   +1 more source