Results 11 to 20 of about 129,688 (259)
HIF drives lipid deposition and cancer in ccRCC via repression of fatty acid metabolism
Nature Communications, 2017 Clear cell renal cancers (ccRCC) display elevated intracellular lipid storage. Here the authors show that such lipid accumulation is due to the repression of carnitine palmitoyltransferase 1A (CPT1A) enzyme that impairs fatty acid (FA) transport into the
Weinan Du +11 more
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Differential regulation of bile acid homeostasis by the farnesoid X receptor in liver and intestine
Journal of Lipid Research, 2007 Bile acid concentrations are controlled by a feedback regulatory pathway whereby activation of the farnesoid X receptor (FXR) represses transcription of both the CYP7A1 gene, encoding the rate-limiting enzyme in the classic bile acid synthesis pathway ...
Insook Kim +7 more
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PLoS Genetics, 2018 Scd6 protein family members are evolutionarily conserved components of translationally silent mRNA granules. Yeast Scd6 interacts with Dcp2 and Dhh1, respectively a subunit and a regulator of the mRNA decapping enzyme, and also associates with ...
Quira Zeidan +5 more
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Epigenetics & Chromatin, 2009 Background Pluripotency, the capacity for indefinite self-renewal and differentiation into diverse cell types is a unique state exhibited by embryonic stem (ES) cells.
Yeap Leng-Siew +2 more
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The Methyltransferase Setd8 Is Essential for Erythroblast Survival and Maturation
Cell Reports, 2017 Erythropoiesis is a highly regulated process that generates enucleate red blood cells from committed erythroid progenitors. Chromatin condensation culminating in enucleation is a defining feature of this process.
Jeffrey Malik +4 more
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Bio-Protocol, 2020 Investigation of bacterial gene regulation upon environmental changes is still a challenging task. For example, Vibrio cholerae, a pathogen of the human gastrointestinal tract, faces diverse transient conditions in different compartments upon oral ...
Franz Zingl +3 more
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Transcriptional Repression of Catalase in Mouse Skin Tumor Progression
Neoplasia: An International Journal for Oncology Research, 2004 Previous studies in our laboratory have shown that the elevation of reactive oxygen species levels and the repression of the antioxidant enzyme, catalase, played a critical role in the in vitro progression of benign papilloma cells to malignant carcinoma
Kevin A. Kwei +3 more
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Catabolite repression of enzyme synthesis does not prevent sporulation [PDF]
Journal of Bacteriology, 1980 In the presence of excess glucose, a decrease of guanine nucleotides in Bacillus subtilis initiated sporulation but did not prevent catabolite repression of three enzymes. Therefore, the ultimate mechanism(s) repressing enzyme synthesis differs from that suppressing sporulation.
J M, Lopez, B, Uratani-Wong, E, Freese
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Differential Evolution of α-Glucan Water Dikinase (GWD) in Plants
Plants, 2020 The alpha-glucan water dikinase (GWD) enzyme catalyzes starch phosphorylation, an integral step in transitory starch degradation. The high phosphate content in stored starch has great industrial value, due to its physio–chemical properties making it more
Muyiwa S. Adegbaju +4 more
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The UBC9 E2 SUMO conjugating enzyme binds the PR-Set7 histone methyltransferase to facilitate target gene repression. [PDF]
PLoS ONE, 2011 PR-Set7/Set8/KMT5a is a chromatin-modifying enzyme that specifically monomethylates lysine 20 of histone H4 (H4K20me1). In this study we attempted to identify PR-Set7-interacting proteins reasoning that these proteins would provide important insights ...
Tanya M Spektor +3 more
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