Results 1 to 10 of about 864,762 (119)
Transcriptional and Post-transcriptional Gene Regulation by Long Non-coding RNA
Genomics, Proteomics & Bioinformatics, 2017 Advances in genomics technology over recent years have led to the surprising discovery that the genome is far more pervasively transcribed than was previously appreciated.
Iain M. Dykes, Costanza Emanueli
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The Roles of RUNX Proteins in Lymphocyte Function and Anti-Tumor Immunity
Cells, 2022 The Runt-related transcription factor (RUNX) family of proteins are crucial for many developmental and immuno-physiological processes. Their importance in cellular and tissue development has been repeatedly demonstrated as they are often found mutated ...
Wooseok Seo +2 more
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Optical Clearing and Light Sheet Microscopy Imaging of Amphioxus
Frontiers in Cell and Developmental Biology, 2021 Cephalochordates (amphioxi or lancelets) are representatives of the most basally divergent group of the chordate phylum. Studies of amphioxus development and anatomy hence provide a key insight into vertebrate evolution.
Simona Machacova +4 more
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Impaired tissue homing by the Ikzf3N159S variant is mediated by interfering with Ikaros function
Frontiers in Immunology, 2023 AIOLOS, encoded by IKZF3, is a member of the IKZF family of proteins that plays an important role in regulating late B-cell differentiation. Human individuals heterozygous for the AIOLOS p.N160S variant displayed impaired humoral immune responses as well
Jingjie Chang +5 more
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Cells, 2023 Chromatin remodeling complexes are required for many distinct nuclear processes such as transcription, DNA replication, and DNA repair. However, the contribution of these complexes to the development of complex tissues within an organism is poorly ...
Andrea Kuzelova +8 more
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Identification of a novel enhancer essential for Satb1 expression in T H 2 cells and activated ILC2s
Life Science Alliance, 2023 The transcriptional mechanisms for Satb1 gene expression are ill-defined. This study identifies a novel enhancer for Satb1 expression in T H 2 cells and to suppress IL-5 production, and for Satb1 expression in activated ILC2s.
Aneela Nomura +9 more
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A lens-specific co-injection marker for medaka transgenesis
BioTechniques, 2010 Recent advances in generating transgenic fish have improved the efficiency of germline transmission and enabled the generation of large numbers of transgenic animals.
Pavel Vopalensky +3 more
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Wnt/β-catenin signaling is an evolutionarily conserved determinant of chordate dorsal organizer
eLife, 2020 Deciphering the mechanisms of axis formation in amphioxus is a key step to understanding the evolution of chordate body plan. The current view is that Nodal signaling is the only factor promoting the dorsal axis specification in the amphioxus, whereas ...
Iryna Kozmikova, Zbynek Kozmik
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Nature Communications, 2020 CCL5 is an important chemokine for modulation of inflammatory responses, but how CCL5 expression is regulated is still unclear. Here the authors show that the CCL5 locus contains two enhancers, with the proximal enhancer being responsible for homeostatic
Wooseok Seo +6 more
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Runx-dependent and silencer-independent repression of a maturation enhancer in the Cd4 gene
Nature Communications, 2018 The commitment of helper and cytotoxic lineages for CD4 and CD8 T cells, respectively, is associated with the regulation of Cd4 gene expression. Here the authors show that an intronic silencer, S4, has differential effects and synergy with the RUNX ...
Satoshi Kojo +4 more
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