Results 31 to 40 of about 1,361,196 (350)

Novel Insights into the Molecular Mechanisms Governing Embryonic Epicardium Formation

Journal of Cardiovascular Development and Disease, 2023
The embryonic epicardium originates from the proepicardium, an extracardiac primordium constituted by a cluster of mesothelial cells. In early embryos, the embryonic epicardium is characterized by a squamous cell epithelium resting on the myocardium ...
Rita Carmona, Carmen López-Sánchez, Virginio Garcia-Martinez, Virginio Garcia-López, Ramón Muñoz-Chápuli, Estefanía Lozano-Velasco, Diego Franco   +6 more
doaj   +1 more source

Underestimated effect of intragenic HIV-1 DNA methylation on viral transcription in infected individuals [PDF]

, 2020
Background: The HIV-1 proviral genome harbors multiple CpG islands (CpGIs), both in the promoter and intragenic regions. DNA methylation in the promoter region has been shown to be heavily involved in HIV-1 latency regulation in cultured cells.
De Meyer, Tim, De Spiegelaere, Ward, Kinloch-de Loes, Sabine, Kint, Sam, Malatinková, Eva, Trypsteen, Wim, Van Criekinge, Wim, Vandekerckhove, Linos   +7 more
core   +2 more sources

An obesity-associated gut microbiome reprograms the intestinal epigenome and leads to altered colonic gene expression

Genome Biology, 2018
Background The gut microbiome, a key constituent of the colonic environment, has been implicated as an important modulator of human health. The eukaryotic epigenome is postulated to respond to environmental stimuli through alterations in chromatin ...
Yufeng Qin, John D. Roberts, Sara A. Grimm, Fred B. Lih, Leesa J. Deterding, Ruifang Li, Kaliopi Chrysovergis, Paul A. Wade   +7 more
doaj   +1 more source

Global landscape of mouse and human cytokine transcriptional regulation [PDF]

, 2018
Cytokines are cell-to-cell signaling proteins that play a central role in immune development, pathogen responses, and diseases. Cytokines are highly regulated at the transcriptional level by combinations of transcription factors (TFs) that recruit ...
Fuxman Bass, Juan Ignacio, Gan, Kok Ann, Imedio, Alvaro Dafonte, Martinez, Melissa, Mehta, Shivani, Pro, Sebastian Carrasco, Santoso, Clarissa Stephanie, Sereda, Rebecca, Sewell, Jared Allan   +8 more
core   +1 more source

Essential Roles of SATB1 in Specifying T Lymphocyte Subsets

Cell Reports, 2017
T cell receptor (TCR) signaling by MHC class I and II induces thymocytes to acquire cytotoxic and helper fates via the induction of Runx3 and ThPOK transcription factors, respectively.
Kiyokazu Kakugawa, Satoshi Kojo, Hirokazu Tanaka, Wooseok Seo, Takaho A. Endo, Yohko Kitagawa, Sawako Muroi, Mari Tenno, Nighat Yasmin, Yoshinori Kohwi, Shimon Sakaguchi, Terumi Kowhi-Shigematsu, Ichiro Taniuchi   +12 more
doaj   +1 more source

Functional Characteristics of Gene Expression Motifs with Single and Dual Strategies of Regulation

, 2016
Transcriptional regulation by transcription factors and post-transcriptional regulation by microRNAs constitute two major modes of regulation of gene expression.
Bose, Indrani, Ghosh, Sayantari, Pal, Mainak   +2 more
core   +1 more source

Characterization of an induced pluripotent stem cell line (IMBPASi001-A) derived from fibroblasts of a patient affected by Wolfram Syndrome

Stem Cell Research, 2020
Wolfram Syndrome is a rare, autosomal recessive genetic disorder with clinical symptoms appearing in early childhood. Here, we report a generation of iPSCs from fibroblasts of a patient affected by this disease.
Dawid P. Grzela, Beata Marciniak, Lukasz Pulaski   +2 more
doaj   +1 more source

Transcriptional and Post-Transcriptional Regulation of Autophagy

Cells, 2022
Autophagy is a widely conserved process in eukaryotes that is involved in a series of physiological and pathological events, including development, immunity, neurodegenerative disease, and tumorigenesis.
Qiuqin Ma, Shihui Long, Zhending Gan, Gianluca Tettamanti, Kang Li, Ling Tian   +5 more
doaj   +1 more source

Priming of lineage-specifying genes by Bcl11b is required for lineage choice in post-selection thymocytes

Nature Communications, 2017
CD4 and CD8 T cells develop in the thymus with their transcription programs controlled by ThPOK and Runx3, respectively. Here the authors show that a pre-commitment event modulated by the transcription factor, Bcl11b, is required for the proper ...
Satoshi Kojo, Hirokazu Tanaka, Takaho A. Endo, Sawako Muroi, Ye Liu, Wooseok Seo, Mari Tenno, Kiyokazu Kakugawa, Yoshinori Naoe, Krutula Nair, Kazuyo Moro, Yoshinori Katsuragi, Akinori Kanai, Toshiya Inaba, Takeshi Egawa, Byrappa Venkatesh, Aki Minoda, Ryo Kominami, Ichiro Taniuchi   +18 more
doaj   +1 more source

Emerging Roles of PRDM Factors in Stem Cells and Neuronal System: Cofactor Dependent Regulation of PRDM3/16 and FOG1/2 (Novel PRDM Factors)

Cells, 2020
PRDI-BF1 (positive regulatory domain I-binding factor 1) and RIZ1 (retinoblastoma protein-interacting zinc finger gene 1) (PR) homologous domain containing (PRDM) transcription factors are expressed in neuronal and stem cell systems, and they exert ...
Paweł Leszczyński, Magdalena Śmiech, Emil Parvanov, Chisato Watanabe, Ken-ichi Mizutani, Hiroaki Taniguchi   +5 more
doaj   +1 more source