Results 31 to 40 of about 2,483,359 (253)

The odyssey of a regulated transcript [PDF]

RNA, 2000
The transcript of the Saccharomyces cerevisiae gene, RPL30, is subject to regulated splicing and regulated translation, due to a structure that interacts with its own product, ribosomal protein L30. We have followed the fate of the regulated RPL30 transcripts in vivo.
J, Vilardell, P, Chartrand, R H, Singer, J R, Warner   +3 more
openaire   +2 more sources

Transcriptional regulation of adipogenesis [PDF]

Genes & Development, 2000
Version of ...
Rosen, Evan D., Walkey, Christopher J., Puigserver, Pere, Spiegelman, Bruce M.   +3 more
openaire   +4 more sources

Delayed puberty, gonadotropin abnormalities and subfertility in male Padi2/Padi4 double knockout mice

Reproductive Biology and Endocrinology, 2022
Background Peptidylarginine deiminase enzymes (PADs) convert arginine residues to citrulline in a process called citrullination or deimination. Recently, two PADs, PAD2 and PAD4, have been linked to hormone signaling in vitro and the goal of this study ...
Kelly L. Sams, Chinatsu Mukai, Brooke A. Marks, Chitvan Mittal, Elena Alina Demeter, Sophie Nelissen, Jennifer K. Grenier, Ann E. Tate, Faraz Ahmed, Scott A. Coonrod   +9 more
doaj   +1 more source

Transcriptional Regulation and Combinatorial Genetic Logic in Synthetic Bacterial Circuits [PDF]

, 2008
We engineered several synthetic regulatory circuits to study transcriptional regulation in bacteria. We developed a new technique for DNA construction, built and characterized in vivo a library of genetic logic gates, examined the role of genetic noise ...
Cox, Robert Sidney, III
core   +1 more source

Runx-dependent and silencer-independent repression of a maturation enhancer in the Cd4 gene

Nature Communications, 2018
The commitment of helper and cytotoxic lineages for CD4 and CD8 T cells, respectively, is associated with the regulation of Cd4 gene expression. Here the authors show that an intronic silencer, S4, has differential effects and synergy with the RUNX ...
Satoshi Kojo, Nighat Yasmin, Sawako Muroi, Mari Tenno, Ichiro Taniuchi   +4 more
doaj   +1 more source

Alterations in promoter interaction landscape and transcriptional network underlying metabolic adaptation to diet

Nature Communications, 2020
Metabolic adaptation to different diets results in changes to gene expression. Here, the authors characterise the chromatin landscape and transcriptional network in mice on a diet of high saturated fat, compared to a diet high in carbohydrate, finding a ...
Yufeng Qin, Sara A. Grimm, John D. Roberts, Kaliopi Chrysovergis, Paul A. Wade   +4 more
doaj   +1 more source

Targeted deficiency of the transcriptional activator Hnf1 alpha alters subnuclear positioning of its genomic targets [PDF]

, 2008
DNA binding transcriptional activators play a central role in gene-selective regulation. In part, this is mediated by targeting local covalent modifications of histone tails.
Luco, Reini F., Sadoni, Nicolas, Maestro, Miguel A., Miguel A Maestro, Luco Reini F., Ferrer Jorge, Zink Daniele, Daniele Zink, Sadoni Nicolas, Nicolas Sadoni, Jorge Ferrer, Maestro Miguel A., Ferrer, Jorge, Reini F Luco, Zink, Daniele   +14 more
core   +2 more sources

Runx/Cbfβ complexes protect group 2 innate lymphoid cells from exhausted-like hyporesponsiveness during allergic airway inflammation

Nature Communications, 2019
Group 2 innate lymphoid cells (ILC2) are important mediators for allergy, but how ILC2 are regulated under chronic inflammation is still unclear. Here the authors show that Runx transcription factors, which normally suppresses ILC2 activation at steady ...
Chizuko Miyamoto, Satoshi Kojo, Motoi Yamashita, Kazuyo Moro, Georges Lacaud, Katsuyuki Shiroguchi, Ichiro Taniuchi, Takashi Ebihara   +7 more
doaj   +1 more source

Author Correction: Runx/Cbfβ complexes protect group 2 innate lymphoid cells from exhausted-like hyporesponsiveness during allergic airway inflammation

Nature Communications, 2019
The original version of this Article contained an error in the author affiliations. Affiliation 5 incorrectly read ‘Laboratory for Prediction of Cell Systems Dynamics, RIKEN Center for Biosystems Dynamics Research (BDR), Suite, Hyogo 565-0874, Japan ...
Chizuko Miyamoto, Satoshi Kojo, Motoi Yamashita, Kazuyo Moro, Georges Lacaud, Katsuyuki Shiroguchi, Ichiro Taniuchi, Takashi Ebihara   +7 more
doaj   +1 more source

LSD1 Facilitates Pro-Inflammatory Polarization of Macrophages by Repressing Catalase

Cells, 2021
The increased level of hydrogen peroxide accompanies some modes of macrophage specification and is linked to ROS-based antimicrobial activity of these phagocytes.
Maciej Sobczak, Magdalena Strachowska, Karolina Gronkowska, Iwona Karwaciak, Łukasz Pułaski, Agnieszka Robaszkiewicz   +5 more
doaj   +1 more source