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Evolution of Regulated Transcription [PDF]
Cells, 2020 The genomes of all organisms abound with various cis-regulatory elements, which control gene activity. Transcriptional enhancers are a key group of such elements in eukaryotes and are DNA regions that form physical contacts with gene promoters and precisely orchestrate gene expression programs.
Oleg V. Bylino +2 more
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ZEB1 protects skeletal muscle from damage and is required for its regeneration
Nature Communications, 2019 Following muscle damage, an inflammatory response is associated to activation of satellite cells, which drive muscle repair. Here, the authors show that upregulation of Zeb1 in macrophages and muscle fibres regulates inflammation, and also show a role ...
Laura Siles +4 more
doaj +1 more source
Essential functions of Runx/Cbfβ in gut conventional dendritic cells for priming Rorγt + T cells
Life Science Alliance, 2020 Loss of Runx/Cbfβ complexes during DC development leads to a loss of gut CD103 + CD11b + cDC2s, which was accompanied with impaired differentiation of both Rorγt + Th17 cells and type 3 Rorγt + Treg cells.
Mari Tenno +12 more
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Novel Insights into the Molecular Mechanisms Governing Embryonic Epicardium Formation
Journal of Cardiovascular Development and Disease, 2023 The embryonic epicardium originates from the proepicardium, an extracardiac primordium constituted by a cluster of mesothelial cells. In early embryos, the embryonic epicardium is characterized by a squamous cell epithelium resting on the myocardium ...
Rita Carmona +6 more
doaj +1 more source
The grammar of transcriptional regulation [PDF]
Human Genetics, 2014 Eukaryotes employ combinatorial strategies to generate a variety of expression patterns from a relatively small set of regulatory DNA elements. As in any other language, deciphering the mapping between DNA and expression requires an understanding of the set of rules that govern basic principles in transcriptional regulation, the functional elements ...
Shira Weingarten-Gabbay, Eran Segal
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The molecular dissection of the regulation of PGC-1α and the genome-wide activity of its transcriptional network in skeletal muscle cells [PDF]
, 2013 The transcriptional coactivator peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) is a potent inducer of mitochondrial biogenesis and oxidative metabolism.
Barešić, Mario
core +1 more source
Modelling transcriptional regulation with a mixture of factor analyzers and variational Bayesian expectation maximization [PDF]
, 2009 Understanding the mechanisms of gene transcriptional regulation through analysis of high-throughput postgenomic data is one of the central problems of computational systems biology.
Husmeier, D. +3 more
core +1 more source
Genome Biology, 2018 Background The gut microbiome, a key constituent of the colonic environment, has been implicated as an important modulator of human health. The eukaryotic epigenome is postulated to respond to environmental stimuli through alterations in chromatin ...
Yufeng Qin +7 more
doaj +1 more source
Essential Roles of SATB1 in Specifying T Lymphocyte Subsets
Cell Reports, 2017 T cell receptor (TCR) signaling by MHC class I and II induces thymocytes to acquire cytotoxic and helper fates via the induction of Runx3 and ThPOK transcription factors, respectively.
Kiyokazu Kakugawa +12 more
doaj +1 more source
Transcriptional Regulators of Angiogenesis [PDF]
Arteriosclerosis, Thrombosis, and Vascular Biology, 2006 Angiogenesis, the process by which new blood vessels develop from a pre-existing vascular network, is essential for normal development and in certain physiological states. Inadequate or excessive angiogenesis has been incriminated in a number of pathologic states.
Anne, Hamik +2 more
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