Results 41 to 50 of about 962,811 (315)
PIN transcriptional regulation shapes root system architecture [PDF]
, 2016 Regulation of auxin distribution by PIN transporters is key in the dynamic modulation of root growth and branching. Three novel papers shed light on an intricate network through which several hormones and transcriptional regulators collectively fine-tune
Guyomarc'h, Soazig +4 more
core +1 more source
Stem Cell Research, 2020 Wolfram Syndrome is a rare, autosomal recessive genetic disorder with clinical symptoms appearing in early childhood. Here, we report a generation of iPSCs from fibroblasts of a patient affected by this disease.
Dawid P. Grzela +2 more
doaj +1 more source
Transcriptional and Post-Transcriptional Regulation of Autophagy
Cells, 2022 Autophagy is a widely conserved process in eukaryotes that is involved in a series of physiological and pathological events, including development, immunity, neurodegenerative disease, and tumorigenesis.
Qiuqin Ma +5 more
doaj +1 more source
Transcriptional regulation of the human ALDH1A1 promoter by the oncogenic homeoprotein TLX1/HOX11
, 2009 The homeoprotein TLX1, which is essential to spleen organogenesis and oncogenic when aberrantly expressed in immature T cells, functions as a bifunctional transcriptional regulator, being capable of activation or repression depending on cell type and/or ...
Heidari, M. +10 more
core +1 more source
Nature Communications, 2017 CD4 and CD8 T cells develop in the thymus with their transcription programs controlled by ThPOK and Runx3, respectively. Here the authors show that a pre-commitment event modulated by the transcription factor, Bcl11b, is required for the proper ...
Satoshi Kojo +18 more
doaj +1 more source
Cells, 2020 PRDI-BF1 (positive regulatory domain I-binding factor 1) and RIZ1 (retinoblastoma protein-interacting zinc finger gene 1) (PR) homologous domain containing (PRDM) transcription factors are expressed in neuronal and stem cell systems, and they exert ...
Paweł Leszczyński +5 more
doaj +1 more source
R-loops in normal and malignant hematopoiesis
Frontiers in Hematology, 2023 An R-loop is a nucleic acid structure consisting of a DNA : RNA hybrid and single-stranded DNA. It is formed physiologically in normal cells and is involved in transcription, replication, and gene rearrangement; in particular, it has multiple roles ...
Mayumi Hirayama +3 more
doaj +1 more source
Regulation of HSV Transcription.
Journal of Investigative Dermatology, 1984 Herpes simplex virus (HSV) transcripts share many features with both cellular mRNA and the mRNAs expressed by other nuclear-replicating DNA viruses: they are capped, polyadenylated, and generally have an approximately 150 base leader between the cap and translation initiation codon.
openaire +2 more sources
Post-transcriptional regulation of glucocorticoid function
, 2015 Glucocorticoids (GCs) are corticosteroid hormones critically involved in the homeostatic control of stress and immune responses. Endogenous GCs generally tend to support the innate immune responses while inhibiting overexpressed adaptive immune responses.
Ishmael, Faoud T. +3 more
core +1 more source
Regulation of Transcript Elongation [PDF]
Annual Review of Microbiology, 2015 Bacteria lack subcellular compartments and harbor a single RNA polymerase that synthesizes both structural and protein-coding RNAs, which are cotranscriptionally processed by distinct pathways. Nascent rRNAs fold into elaborate secondary structures and associate with ribosomal proteins, whereas nascent mRNAs are translated by ribosomes.
Georgiy A, Belogurov +1 more
openaire +2 more sources