Results 21 to 30 of about 3,231,478 (258)

LSD1 Facilitates Pro-Inflammatory Polarization of Macrophages by Repressing Catalase

Cells, 2021
The increased level of hydrogen peroxide accompanies some modes of macrophage specification and is linked to ROS-based antimicrobial activity of these phagocytes.
Maciej Sobczak, Magdalena Strachowska, Karolina Gronkowska, Iwona Karwaciak, Łukasz Pułaski, Agnieszka Robaszkiewicz   +5 more
doaj   +1 more source

ZEB1 protects skeletal muscle from damage and is required for its regeneration

Nature Communications, 2019
Following muscle damage, an inflammatory response is associated to activation of satellite cells, which drive muscle repair. Here, the authors show that upregulation of Zeb1 in macrophages and muscle fibres regulates inflammation, and also show a role ...
Laura Siles, Chiara Ninfali, Marlies Cortés, Douglas S. Darling, Antonio Postigo   +4 more
doaj   +1 more source

Challenges and Advances in the Taxonomy of Deep-Sea Peracarida: From Traditional to Modern Methods

Frontiers in Marine Science, 2022
As one of the oldest branches of biology, taxonomy deals with the identification, classification and naming of living organisms, using a variety of tools to explore traits at the morphological and molecular level.
Inmaculada Frutos, Stefanie Kaiser, Łukasz Pułaski, Łukasz Pułaski, Maciej Studzian, Maciej Studzian, Magdalena Błażewicz   +6 more
doaj   +1 more source

Essential functions of Runx/Cbfβ in gut conventional dendritic cells for priming Rorγt + T cells

Life Science Alliance, 2020
Loss of Runx/Cbfβ complexes during DC development leads to a loss of gut CD103 + CD11b + cDC2s, which was accompanied with impaired differentiation of both Rorγt + Th17 cells and type 3 Rorγt + Treg cells.
Mari Tenno, Alicia Yoke Wei Wong, Mika Ikegaya, Eiji Miyauchi, Wooseok Seo, Peter See, Tamotsu Kato, Takashi Taida, Michiko Ohno-Oishi, Hiroshi Ohno, Hideyuki Yoshida, Florent Ginhoux, Ichiro Taniuchi   +12 more
doaj   +1 more source

The molecular dissection of the regulation of PGC-1α and the genome-wide activity of its transcriptional network in skeletal muscle cells [PDF]

, 2013
The transcriptional coactivator peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) is a potent inducer of mitochondrial biogenesis and oxidative metabolism.
Barešić, Mario
core   +1 more source

Novel Insights into the Molecular Mechanisms Governing Embryonic Epicardium Formation

Journal of Cardiovascular Development and Disease, 2023
The embryonic epicardium originates from the proepicardium, an extracardiac primordium constituted by a cluster of mesothelial cells. In early embryos, the embryonic epicardium is characterized by a squamous cell epithelium resting on the myocardium ...
Rita Carmona, Carmen López-Sánchez, Virginio Garcia-Martinez, Virginio Garcia-López, Ramón Muñoz-Chápuli, Estefanía Lozano-Velasco, Diego Franco   +6 more
doaj   +1 more source

An obesity-associated gut microbiome reprograms the intestinal epigenome and leads to altered colonic gene expression

Genome Biology, 2018
Background The gut microbiome, a key constituent of the colonic environment, has been implicated as an important modulator of human health. The eukaryotic epigenome is postulated to respond to environmental stimuli through alterations in chromatin ...
Yufeng Qin, John D. Roberts, Sara A. Grimm, Fred B. Lih, Leesa J. Deterding, Ruifang Li, Kaliopi Chrysovergis, Paul A. Wade   +7 more
doaj   +1 more source

Essential Roles of SATB1 in Specifying T Lymphocyte Subsets

Cell Reports, 2017
T cell receptor (TCR) signaling by MHC class I and II induces thymocytes to acquire cytotoxic and helper fates via the induction of Runx3 and ThPOK transcription factors, respectively.
Kiyokazu Kakugawa, Satoshi Kojo, Hirokazu Tanaka, Wooseok Seo, Takaho A. Endo, Yohko Kitagawa, Sawako Muroi, Mari Tenno, Nighat Yasmin, Yoshinori Kohwi, Shimon Sakaguchi, Terumi Kowhi-Shigematsu, Ichiro Taniuchi   +12 more
doaj   +1 more source

Characterization of an induced pluripotent stem cell line (IMBPASi001-A) derived from fibroblasts of a patient affected by Wolfram Syndrome

Stem Cell Research, 2020
Wolfram Syndrome is a rare, autosomal recessive genetic disorder with clinical symptoms appearing in early childhood. Here, we report a generation of iPSCs from fibroblasts of a patient affected by this disease.
Dawid P. Grzela, Beata Marciniak, Lukasz Pulaski   +2 more
doaj   +1 more source

Priming of lineage-specifying genes by Bcl11b is required for lineage choice in post-selection thymocytes

Nature Communications, 2017
CD4 and CD8 T cells develop in the thymus with their transcription programs controlled by ThPOK and Runx3, respectively. Here the authors show that a pre-commitment event modulated by the transcription factor, Bcl11b, is required for the proper ...
Satoshi Kojo, Hirokazu Tanaka, Takaho A. Endo, Sawako Muroi, Ye Liu, Wooseok Seo, Mari Tenno, Kiyokazu Kakugawa, Yoshinori Naoe, Krutula Nair, Kazuyo Moro, Yoshinori Katsuragi, Akinori Kanai, Toshiya Inaba, Takeshi Egawa, Byrappa Venkatesh, Aki Minoda, Ryo Kominami, Ichiro Taniuchi   +18 more
doaj   +1 more source