Results 21 to 30 of about 2,483,359 (253)
The transcriptional regulator GLYR1 may mediate NNMT down-regulation.
, 2023 The transcriptional regulator GLYR1 may mediate NNMT down-regulation.
Sarkies, Peter +3 more
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Regulation of Transcript Elongation [PDF]
Annual Review of Microbiology, 2015 Bacteria lack subcellular compartments and harbor a single RNA polymerase that synthesizes both structural and protein-coding RNAs, which are cotranscriptionally processed by distinct pathways. Nascent rRNAs fold into elaborate secondary structures and associate with ribosomal proteins, whereas nascent mRNAs are translated by ribosomes.
Georgiy A, Belogurov +1 more
openaire +2 more sources
A lens-specific co-injection marker for medaka transgenesis
BioTechniques, 2010 Recent advances in generating transgenic fish have improved the efficiency of germline transmission and enabled the generation of large numbers of transgenic animals.
Pavel Vopalensky +3 more
doaj +1 more source
Wnt/β-catenin signaling is an evolutionarily conserved determinant of chordate dorsal organizer
eLife, 2020 Deciphering the mechanisms of axis formation in amphioxus is a key step to understanding the evolution of chordate body plan. The current view is that Nodal signaling is the only factor promoting the dorsal axis specification in the amphioxus, whereas ...
Iryna Kozmikova, Zbynek Kozmik
doaj +1 more source
Transcriptional Regulation by P53 [PDF]
Cold Spring Harbor Perspectives in Biology, 2010 Inactivation of p53 is critical for the formation of most tumors. Illumination of the key function(s) of p53 protein in protecting cells from becoming cancerous is therefore a worthy goal. Arguably p53's most important function is to act as a transcription factor that directly regulates perhaps several hundred of the cell's RNA polymerase II (RNAP II ...
Rachel, Beckerman, Carol, Prives
openaire +2 more sources
Transcriptional Regulation of Inflammasomes [PDF]
International Journal of Molecular Sciences, 2020 Inflammasomes are multimolecular complexes with potent inflammatory activity. As such, their activity is tightly regulated at the transcriptional and post-transcriptional levels. In this review, we present the transcriptional regulation of inflammasome genes from sensors (e.g NLRP3) to substrates (e.g. IL-1β). Lineage-determining transcription
Cornut, Maxence +2 more
openaire +4 more sources
Transcriptional regulation of the urokinase receptor (u-PAR) - A central molecule of invasion and metastasis [PDF]
, 2003 The phenomenon of tumor-associated proteolysis has been acknowledged as a decisive step in the progression of cancer. This short review focuses on the urokinase receptor (u-PAR), a central molecule involved in tumor-associated invasion and metastasis ...
Fuchs, T., Allgayer, H.
core +1 more source
Nature Communications, 2020 CCL5 is an important chemokine for modulation of inflammatory responses, but how CCL5 expression is regulated is still unclear. Here the authors show that the CCL5 locus contains two enhancers, with the proximal enhancer being responsible for homeostatic
Wooseok Seo +6 more
doaj +1 more source
Transcriptional regulation by STAT6 [PDF]
Immunologic Research, 2011 Signal transducer and activator of transcription (STAT) proteins are critical mediators of cytokine signaling. Among the seven STAT proteins, STAT6 is activated by IL-4 and IL-13 and plays a predominant role in the immune system. However, there is increasing evidence that STAT6 may function in other tissues and organ systems.
Shreevrat, Goenka, Mark H, Kaplan
openaire +2 more sources
Transcriptional regulation of the human ALDH1A1 promoter by the oncogenic homeoprotein TLX1/HOX11 [PDF]
, 2009 The homeoprotein TLX1, which is essential to spleen organogenesis and oncogenic when aberrantly expressed in immature T cells, functions as a bifunctional transcriptional regulator, being capable of activation or repression depending on cell type and/or ...
Heidari, M. +10 more
core +1 more source