Transcriptional downregulation of agr expression in Staphylococcus aureus during growth in human serum can be overcome by constitutively active mutant forms of the sensor kinase AgrC [PDF]
, 2013 The temporal and cell density-dependent regulation of expression of virtually all the Staphylococcus aureus virulon is under the control of the agr (accessory gene regulatory) operon.
Edwards, AM +2 more
core +1 more source
Circadian rhythms and post-transcriptional regulation in higher plants [PDF]
, 2015 The circadian clock of plants allows them to cope with daily changes in their environment. This is accomplished by the rhythmic regulation of gene expression, in a process that involves many regulatory steps.
Romanowski, Andrés +1 more
core +3 more sources
Nature Communications, 2019 Group 2 innate lymphoid cells (ILC2) are important mediators for allergy, but how ILC2 are regulated under chronic inflammation is still unclear. Here the authors show that Runx transcription factors, which normally suppresses ILC2 activation at steady ...
Chizuko Miyamoto +7 more
doaj +1 more source
LSD1 Facilitates Pro-Inflammatory Polarization of Macrophages by Repressing Catalase
Cells, 2021 The increased level of hydrogen peroxide accompanies some modes of macrophage specification and is linked to ROS-based antimicrobial activity of these phagocytes.
Maciej Sobczak +5 more
doaj +1 more source
Nature Communications, 2019 The original version of this Article contained an error in the author affiliations. Affiliation 5 incorrectly read ‘Laboratory for Prediction of Cell Systems Dynamics, RIKEN Center for Biosystems Dynamics Research (BDR), Suite, Hyogo 565-0874, Japan ...
Chizuko Miyamoto +7 more
doaj +1 more source
Challenges and Advances in the Taxonomy of Deep-Sea Peracarida: From Traditional to Modern Methods
Frontiers in Marine Science, 2022 As one of the oldest branches of biology, taxonomy deals with the identification, classification and naming of living organisms, using a variety of tools to explore traits at the morphological and molecular level.
Inmaculada Frutos +6 more
doaj +1 more source
Estrogen-related receptor α (ERRα) : a novel target in type 2 diabetes [PDF]
, 2005 Recent studies have shown that reduced mitochondrial content and function in skeletal muscle are common features of type 2 diabetes. Here, we review the molecular mechanisms involved in the regulation of mitochondrial genes in skeletal muscle, focusing ...
Handschin, C., Mootha, V. K.
core +1 more source
ZEB1 protects skeletal muscle from damage and is required for its regeneration
Nature Communications, 2019 Following muscle damage, an inflammatory response is associated to activation of satellite cells, which drive muscle repair. Here, the authors show that upregulation of Zeb1 in macrophages and muscle fibres regulates inflammation, and also show a role ...
Laura Siles +4 more
doaj +1 more source
Essential functions of Runx/Cbfβ in gut conventional dendritic cells for priming Rorγt + T cells
Life Science Alliance, 2020 Loss of Runx/Cbfβ complexes during DC development leads to a loss of gut CD103 + CD11b + cDC2s, which was accompanied with impaired differentiation of both Rorγt + Th17 cells and type 3 Rorγt + Treg cells.
Mari Tenno +12 more
doaj +1 more source
HTRIdb: an open-access database for experimentally verified human transcriptional regulation interactions [PDF]
, 2012 Background: The modeling of interactions among transcription factors (TFs) and their respective target genes (TGs) into transcriptional regulatory networks is important for the complete understanding of regulation of biological processes.
Luiz A. Bovolenta +2 more
core +4 more sources