Results 201 to 210 of about 129,688 (259)

TDP‐43 Aggregation: The Healthy‐Toxic Balance of the Prion‐Like Domain

Advanced Science, EarlyView.
TDP‐43 function relies on a delicate balance between reversible phase‐separated states and irreversible aggregation. Under physiological conditions, TDP‐43 forms dynamic droplets and oligomers that support normal cellular functions. In pathological contexts, this balance shifts toward aberrant aggregation, leading to toxic species.
Luca Zangrando, Emanuele Buratti, Francesca Paron   +2 more
wiley   +1 more source

Natural variation in Arabidopsis uncouples leaf and flower development and reveals massive transcriptomic heterochrony. [PDF]

J Exp Bot
Dieudonné S, Kristianingsih R, Hallet S, Jesson B, Vidal V, Wells R, Morris RJ, Besnard F.   +7 more
europepmc   +1 more source

Aspects of Repression in the Regulation of Enzyme Synthesis: Pathway-Wide Control and Enzyme-Specific Response

Cold Spring Harbor Symposia on Quantitative Biology, 1961
openaire   +2 more sources

A Biomimetic Dual‐Targeting Nano‐APA‐Editor Reprograms the 3'UTR Landscape for Tongue Squamous Cell Carcinoma Therapy

Advanced Science, EarlyView.
This study unveils a pathogenic axis in oral cancer where NUDT21 suppresses a tumor suppressor network, prominently PTEN, via 3'UTR lengthening. To exploit this transcriptomic vulnerability, we developed a biomimetic Nano‐APA‐editor. By delivering CRISPR/Cas9, we reprogrammed the global 3'UTR landscape, restoring multi‐target tumor suppression and ...
Yiran Ao, Bin Gu, Hui Zhao, Kun Tan, Qin Zhao, Zhengjun Shang   +5 more
wiley   +1 more source

The role of epigenetic modifications in hematological cancers. [PDF]

Front Oncol
Ilic J, Bold A, Knop S.
europepmc   +1 more source

Transcription and cohesin direct domain boundary spatial positioning and are linked to Friedreich's ataxia. [PDF]

Mol Cell
Karnay A, Linares-Saldana R, Wang Q, Gardner Z, Liang JA, Santini GT, Haridhasapavalan KK, Nguyen SC, Hugelier S, Shewale B, Kanemaki MT, Napierala JS, Napierala M, Wilson RB, Dubois N, Poleshko A, Kim W, Shah PP, Lakadamyali M, Joyce EF, Jain R.   +20 more
europepmc   +1 more source

Therapeutic implications of epigenetic alterations in burns: a new frontier in burn medicine. [PDF]

Clin Sci (Lond)
Timpano S, Farahat M, Jeschke MG.
europepmc   +1 more source

Epigenetically regulated transcriptional repressor, BASIC PENTACYSTEINE1 (BPC1) acts together with polycomb repressive complex 2 (PRC2) to suppress camalexin biosynthesis in Arabidopsis. [PDF]

Plant Mol Biol
Moon H, Choi D, Cho E, Kim H, Nugroho ABD, Kim DH.   +5 more
europepmc   +1 more source

Transposon insertion sequencing identifies novel genes involved in product synthesis in gas-fermenting <i>Clostridium ljungdahlii</i>. [PDF]

Synth Syst Biotechnol
Zhang Z, Yang F, Liu Y, Ye W, Jia D, Tian Y, Jiang W, Wang Q, Gu Y.   +8 more
europepmc   +1 more source