Results 261 to 270 of about 2,217,916 (339)

The Impact of Polycomb Group Proteins on 3D Chromatin Structure and Environmental Stresses in Plants. [PDF]

Plants (Basel)
Liu Y, Xiao S, Yang M, Guo G, Zhou Y.
europepmc   +1 more source

Fresh insights into the light‐induced pineal gland circadian rhythm transmission mechanism derived from mRNA and miRNA profiling

Animal Research and One Health, EarlyView.
Mechanisms of light in regulating the chick pineal clock. Abstract The circadian clock significantly impacts animal health and productivity, with light playing a crucial role in regulating circadian rhythms. However, the mechanisms behind light‐induced circadian transmission remain unclear, particularly in light‐sensitive avian species.
Yunlei Li, Yanyan Sun, Jingwei Yuan, Xiangchen Li, Lei Shi, Adamu Mani Isa, Yuanmei Wang, Pingzhuang Ge, Yunhe Zong, Panlin Wang, Jilan Chen   +10 more
wiley   +1 more source

Melatonin Mitigates Cd-Induced Growth Repression and RNA m⁶A Hypermethylation by Triggering MMR-Mediated DNA Damage Response. [PDF]

Plants (Basel)
Tang Z, Wang H, Wang X, Ludlow RA, Liu Z, Zhang M, Cao Q, Liu W, Zhao Q.   +8 more
europepmc   +1 more source

TRIB3 suppresses milk fatty acids metabolism by inhibiting p‐AKT/PPARG signaling in goat mammary epithelial cells

Animal Research and One Health, EarlyView.
In this study, it revealed that TRIB3 could mediate the transcriptional activity of PPARG, inhibit the phosphorylation of akt, and reduce the expression of lipid metabolism‐related genes, thus inhibiting TAG synthesis and affecting fatty acid composition.
Xinglong Gong, Tan Pan, Tiantian Xiong, Yifan Zhu, Juan J. Loor, Chengming Han, Yifan Li, Huan Lei, Jun Luo, Cong Li   +9 more
wiley   +1 more source

Establishment of CRISPR-STAR System to Realise Simultaneous Transcriptional Activation and Repression in Yarrowia lipolytica. [PDF]

Microb Biotechnol
Chen Y, Li M, Liu X, Duan Q, Xiao L, Wang L, Huang C, Song H, Cao Y.   +8 more
europepmc   +1 more source

Metabolic Stress Expands Polyfunctional, Proinflammatory Th17 Cells in Patients With Psoriatic Arthritis for Whom There is Interleukin‐23–Independent Interleukin‐17 Production

Arthritis &Rheumatology, EarlyView.
Objective Genetic associations and blockade of the interleukin (IL)‐23/IL‐17 axis with monoclonal antibodies support a role for this pathway in patients with psoriatic arthritis (PsA). This study examines the requirement of IL‐23 for IL‐17 production and the role of the metabolic microenvironment in the expansion of Th17‐derived cells in patients with ...
Carmel B. Stober, Louise Ellis, Jane C. Goodall, Marc Veldhoen, J. S. Hill Gaston   +4 more
wiley   +1 more source

Development of a CRISPR activation system for targeted gene upregulation in Synechocystis sp. PCC 6803. [PDF]

Commun Biol
Bourgade B, Xie H, Lindblad P, Stensjö K.   +3 more
europepmc   +1 more source

Aberrant glycosylation of IgG in children with active lupus nephritis alters podocyte metabolism and causes podocyte injury

Arthritis &Rheumatology, Accepted Article.
Background Podocytes are integral to the maintenance of the glomerular filtration barrier. Their injury results in proteinuria and disease progression in lupus nephritis (LN). Aberrant IgG glycosylation drives podocyte injury in LN and leads to cytoskeletal rearrangement, motility changes and decreased nephrin production.
Rhea Bhargava, Rohit Upadhyay, Cong Zhao, Prasad Katakam, Scott Wenderfer, Jing Chen, Hua He, Richard Cummings, Maria G. Tsokos, George C. Tsokos   +9 more
wiley   +1 more source

Mitigating host microRNA interference to enhance mRNA vaccine efficacy in public health interventions. [PDF]

Infect Dis Poverty
Xu T, Lin Z, Yu Y, Irfan M, Ahmed M, Septriana M, Sumantri TZC, Amalia AW, Zheng B.   +8 more
europepmc   +1 more source

Gout and NLRP3 inflammasome biology

Arthritis &Rheumatology, Accepted Article.
This review describes the three broad stages of acute inflammation in the context of gout: initiation, leucocyte mobilisation, and self‐resolution. A typical case of a gout flare is presented. The role of the NLRP3 inflammasome in acute monosodium urate crystal‐induced inflammation is reviewed in detail.
Raewyn Poulsen, Nicola Dalbeth
wiley   +1 more source