Results 41 to 50 of about 559,990 (314)

Enhanced oral absorption of insulin: hydrophobic ion pairing and a self-microemulsifying drug delivery system using a D-optimal mixture design

Drug Delivery, 2022
The lipophilicity of a peptide drug can be considerably increased by hydrophobic ion pairing with amphiphilic counterions for successful incorporation into lipid-based formulations.
Yoon Tae Goo, Sangkil Lee, Ji Yeh Choi, Min Song Kim, Gi Hyeong Sin, Sun Ho Hong, Chang Hyun Kim, Seh Hyon Song, Young Wook Choi   +8 more
doaj   +1 more source

Effects of the Fluid Replacement Method During Online Hemodiafiltration on the Solute Removal Performance and Biocompatibility Using the Asymmetric Cellulose Triacetate Membrane

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Pre‐dilution online hemodiafiltration (Pre‐HDF) is predominantly used in Japan, whereas post‐dilution online HDF (Post‐HDF) is more common in Europe. An asymmetric cellulose triacetate (ATA) membrane may improve biocompatibility.
Kenji Sakurai, Yoshitaka Kurihara, Fumi Yamauchi, Hiromi Hosoya, Takeshi Saito   +4 more
wiley   +1 more source

Enzyme-Assisted Extraction of Bioactive Compounds from Rosa canina L. Pseudofruit in Natural Deep Eutectic Solvents: Protease Stability and Biological Activities

Plants
Enzyme-Assisted Extraction (EAE) in Natural Deep Eutectic Solvents (NaDES) was investigated as a green approach to extract bioactive compounds from the pseudofruit of Rosa canina L.
Lemoni Zafeiria, Tzani Andromachi, Karagianni Alexandra, Stavropoulos Georgios, Lymperopoulou Theopisti, Alexandratou Eleni, Detsi Anastasia, Mamma Diomi   +7 more
doaj   +1 more source

Escherichia coli Fails to Efficiently Maintain the Activity of an Important Flavin Monooxygenase in Recombinant Overexpression

Frontiers in Microbiology, 2017
This paper describes the measurement and analysis of in vivo activity and stability of cyclohexanone monooxygenase from Acinetobacter sp. NCIMB 9871 (CHMO), a model Baeyer–Villiger monooxygenase, in the recombinant host Escherichia coli.
Sofia Milker, Leticia C. P. Goncalves, Michael J. Fink, Michael J. Fink, Florian Rudroff   +4 more
doaj   +1 more source

Experience With Performing Rheocarna Therapy via the Single‐Needle Method for Treatment of Chronic Limb‐Threatening Ischemia

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction This study investigated the safety and efficacy of single‐needle Rheocarna therapy for chronic limb‐threatening ischemia (CLTI) with wounds. Methods Six patients with CLTI involving ulcers unresponsive to revascularization underwent single‐needle Rheocarna treatment.
Yasutaka Yamauchi, Rie Tanaka, Reona Kawahira, Shingo Nabeta, Kouhei Naoi, Kazuhito Kitajima, Akira Wada, Tomonari Takagi, Norihiko Ohura, Akira Miyamoto   +9 more
wiley   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

The Role of Surface Exposed Lysine in Conformational Stability and Functional Properties of Lipase from Staphylococcus Family

Molecules, 2020
Surface charge residues have been recognized as one of the stability determinants in protein. In this study, we sought to compare and analyse the stability and conformational dynamics of staphylococcal lipase mutants with surface lysine mutation using ...
Nurul Nadirah Ahmad, Nor Hafizah Ahmad Kamarudin, Adam Thean Chor Leow, Raja Noor Zaliha Raja Abd. Rahman   +3 more
doaj   +1 more source

Immobilization of α-galactosidase from Clitocybe squamulose and its Hydrolysis of Oigosaccharides in Soybean Milk

Liang you shipin ke-ji, 2022
Sodium alginate embedding method and chitosan crosslinking method were used to immobilize α -galactosidase from Clitocybe squamulosa. The optimum pH, pH stability, optimum temperature, temperature stability, storage time of immobilized enzyme and free ...
ZUO Ning-ke, CHANG Ming-chang, MENG Jun-long, WANG Zhao-yu, WU Bin, XU Li-jing   +5 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source