Results 141 to 150 of about 784,273 (205)

Targeted Enzyme Prodrug Therapies

Mini-Reviews in Medicinal Chemistry, 2010
The cure of cancer is still a formidable challenge in medical science. Long-known modalities including surgery, chemotherapy and radiotherapy are successful in a number of cases; however, invasive, metastasized and inaccessible tumors still pose an unresolved and ongoing problem. Targeted therapies designed to locate, detect and specifically kill tumor
N, Schellmann, P M, Deckert, D, Bachran, H, Fuchs, C, Bachran   +4 more
openaire   +2 more sources

Pancreatic enzyme supplementation therapy

Current Treatment Options in Gastroenterology, 2003
Effective treatment of malabsorption due to severe pancreatic exocrine insufficiency requires delivery of sufficient enzymatic activity into the duodenal lumen simultaneously with meal nutrients. To achieve this, modern therapeutic concepts recommend administration of 25,000 to 40,000 units of lipase per meal using pH-sensitive pancreatin microspheres.
Jutta, Keller, Peter, Layer
openaire   +2 more sources

Fibrinolytic Enzymes for Thrombolytic Therapy

2019
Cardiovascular diseases are a group of disorders consisting importantly of coronary heart disease, peripheral arterial disease, cerebrovascular disease, rheumatic heart disease, congenital heart disease, deep vein thrombosis and pulmonary embolism. Severe cardiovascular disease conditions lead to acute myocardial infarction and stroke.
Swaroop S, Kumar, Abdulhameed, Sabu
openaire   +2 more sources

Pancreatic enzyme replacement therapy

Current Gastroenterology Reports, 2001
Malabsorption due to severe pancreatic exocrine insufficiency is one of the most important late features of chronic pancreatitis. Generally, steatorrhea is more severe and occurs several years prior to malabsorption of other nutrients because synthesis and secretion of lipase are impaired more rapidly, its intraluminal survival is shorter, and the lack
P, Layer, J, Keller, P G, Lankisch
openaire   +2 more sources

Enzyme Replacement Therapy for the Sphingolipidoses

1976
The greatest progress in the field of inheritable disorders during the past decade was made in the understanding and control of lipid storage diseases. Since original demonstrations in 1965 and 1966 of the metabolic defects in Gaucher’s disease (6,7) Niemann-Pick disease (8), Fabry’s disease (9), and metachromatic leukodystrophy (17), specific enzyme ...
R O, Brady, P G, Pentchev, A E, Gal, S R, Hibbert, J M, Quirk, G E, Mook, J W, Kusiak, J F, Tallman, A S, Dekaban   +8 more
openaire   +2 more sources