Results 1 to 10 of about 20,773 (118)
Prodrugs for Improved Drug Delivery: Lessons Learned from Recently Developed and Marketed Products
Pharmaceutics, 2020 Prodrugs are bioreversible, inactive drug derivatives, which have the ability to convert into a parent drug in the body. In the past, prodrugs were used as a last option; however, nowadays, prodrugs are considered already in the early stages of drug ...
Milica Markovic +2 more
exaly +3 more sources
Study on the synthesis, physicochemical properties and transdermal absorption of scutellarein prodrugs [PDF]
Scientific ReportsIn this research, we aimed to improve the lipid solubility and transdermal absorbability of scutellarein through a prodrug strategy, and then improve its efficacy for treating psoriasis.
Ping Wang +3 more
doaj +2 more sources
Newly Developed Prodrugs and Prodrugs in Development; an Insight of the Recent Years
Molecules, 2020 Background: The design and development of prodrugs is the most common and effective strategy to overcome pharmacokinetic and pharmacodynamic drawbacks of active drugs.
Anas Najjar +2 more
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Drugs and Drug Candidates, 2023 Based on the demonstrated and reported trypanocidal, leishmanicidal, and antiplasmodial activities of two menthol prodrugs, it was decided to proceed with preformulation studies, which are of key relevance in the drug discovery process.
Camila M. Clemente +4 more
doaj +1 more source
Ligand Evolution in the Photoactivatable Platinum(IV) Anticancer Prodrugs
Frontiers in Chemistry, 2022 Photoactivatable Pt(IV) anticancer prodrugs with the structure of [PtIV(N1)(N2)(L1)(L2)(A1)(A2)], where N1 and N2 are non-leaving nitrogen donor ligands, L1 and L2 are leaving ligands, and A1 and A2 are axial ligands, have attracted increasing attention ...
Jingjing Huang +9 more
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N-Alkylaminoferrocene-Based Prodrugs Targeting Mitochondria of Cancer Cells
Molecules, 2020 Intracellular concentration of reactive oxygen species (e.g., H2O2) in cancer cells is elevated over 10-fold as compared to normal cells. This feature has been used by us and several other research groups to design cancer specific prodrugs, for example ...
Viktor Reshetnikov +7 more
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Chemical Characterization and Pharmacological Evaluation of Phytophenols-Etodolac Mutual Prodrugs
Iraqi Journal of Pharmaceutical Sciences, 2023 Etodolac is choice of drug for pain and inflammation but has major side effects of gastric ulcers that are due to free carboxylic group. Etodolac belongs to the chemical class of non-selective COX-inhibitor but preferentially COX-2 inhibitor.
Kamal Shah, Gaurav Krishna
doaj +1 more source
Activation and Delivery of Tetrazine-Responsive Bioorthogonal Prodrugs
Molecules, 2020 Prodrugs, which remain inert until they are activated under appropriate conditions at the target site, have emerged as an attractive alternative to drugs that lack selectivity and show off-target effects.
Yayue Wang +3 more
doaj +1 more source
Increased/Targeted Brain (Pro)Drug Delivery via Utilization of Solute Carriers (SLCs)
Pharmaceutics, 2022 Membrane transporters have a crucial role in compounds’ brain drug delivery. They allow not only the penetration of a wide variety of different compounds to cross the endothelial cells of the blood–brain barrier (BBB), but also the accumulation of them ...
Johanna Huttunen +3 more
doaj +1 more source
Journal of Advanced Research, 2017 Prodrugs, the inert derivatives of existing drugs have successfully contributed to the modification of their physicochemical properties. The improved antimicrobial potential due to enhanced lipophilicity of some of the synthesized prodrugs of ...
Mona Piplani +2 more
doaj +1 more source