Results 1 to 10 of about 33,100 (295)
N-Alkylaminoferrocene-Based Prodrugs Targeting Mitochondria of Cancer Cells [PDF]
Molecules, 2020 Intracellular concentration of reactive oxygen species (e.g., H2O2) in cancer cells is elevated over 10-fold as compared to normal cells. This feature has been used by us and several other research groups to design cancer specific prodrugs, for example ...
Viktor Reshetnikov +7 more
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Activation and Delivery of Tetrazine-Responsive Bioorthogonal Prodrugs
Molecules, 2020 Prodrugs, which remain inert until they are activated under appropriate conditions at the target site, have emerged as an attractive alternative to drugs that lack selectivity and show off-target effects.
Yayue Wang +3 more
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Hypoxia-Responsive Fluorescent Prodrugs: Self-Reporting Drug Delivery or Activation in Living Systems [PDF]
BiosensorsHypoxia is a hallmark of numerous pathological conditions, such as cancer, drug-induced liver injury, and rheumatoid arthritis. Given the contrast in oxygen levels between pathological and normal tissues, hypoxia-activated prodrugs have been developed by
Xiaomu Hu +3 more
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Chemical Characterization and Pharmacological Evaluation of Phytophenols-Etodolac Mutual Prodrugs
Iraqi Journal of Pharmaceutical Sciences, 2023 Etodolac is choice of drug for pain and inflammation but has major side effects of gastric ulcers that are due to free carboxylic group. Etodolac belongs to the chemical class of non-selective COX-inhibitor but preferentially COX-2 inhibitor.
Kamal Shah, Gaurav Krishna
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Prodrugs for Improved Drug Delivery: Lessons Learned From Recently Developed and Marketed Products
Pharmaceutics, 2020 Prodrugs are bioreversible, inactive drug derivatives, which have the ability to convert into a parent drug in the body. In the past, prodrugs were used as a last option; however, nowadays, prodrugs are considered already in the early stages of drug ...
Shimon Ben-Shabat +2 more
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Do We Still Need Chemistry for Water-Soluble Prodrugs? What Biocatalysis Already Does, and What It Does Not [PDF]
PharmaceuticsPoor aqueous solubility limits roughly 40% of marketed oral drugs and up to ~90% of development candidates. One established remedy is the prodrug strategy: the covalent attachment of a bioreversible promoiety that regenerates the parent drug in vivo. The
Federico Zappaterra +4 more
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Newly Developed Prodrugs and Prodrugs in Development; an Insight of the Recent Years
Molecules, 2020 Background: The design and development of prodrugs is the most common and effective strategy to overcome pharmacokinetic and pharmacodynamic drawbacks of active drugs.
Anas Najjar +2 more
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Drugs and Drug Candidates, 2023 Based on the demonstrated and reported trypanocidal, leishmanicidal, and antiplasmodial activities of two menthol prodrugs, it was decided to proceed with preformulation studies, which are of key relevance in the drug discovery process.
Camila M. Clemente +4 more
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Ligand Evolution in the Photoactivatable Platinum(IV) Anticancer Prodrugs
Frontiers in Chemistry, 2022 Photoactivatable Pt(IV) anticancer prodrugs with the structure of [PtIV(N1)(N2)(L1)(L2)(A1)(A2)], where N1 and N2 are non-leaving nitrogen donor ligands, L1 and L2 are leaving ligands, and A1 and A2 are axial ligands, have attracted increasing attention ...
Jingjing Huang +9 more
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Journal of Advanced Research, 2017 Prodrugs, the inert derivatives of existing drugs have successfully contributed to the modification of their physicochemical properties. The improved antimicrobial potential due to enhanced lipophilicity of some of the synthesized prodrugs of ...
Mona Piplani +2 more
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