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Molecules, 2016 The main objective of this review is to describe the importance of dendrimer prodrugs in the design of new drugs, presenting numerous applications of these nanocomposites in the pharmaceutical field.
Jeanine Giarolla Vargas +2 more
exaly +6 more sources
Newly Developed Prodrugs and Prodrugs in Development; an Insight of the Recent Years [PDF]
Molecules, 2020 Background: The design and development of prodrugs is the most common and effective strategy to overcome pharmacokinetic and pharmacodynamic drawbacks of active drugs.
Anas Najjar +2 more
doaj +5 more sources
Prodrugs for Improved Drug Delivery: Lessons Learned from Recently Developed and Marketed Products
Pharmaceutics, 2020 Prodrugs are bioreversible, inactive drug derivatives, which have the ability to convert into a parent drug in the body. In the past, prodrugs were used as a last option; however, nowadays, prodrugs are considered already in the early stages of drug ...
Milica Markovic +2 more
doaj +2 more sources
Dopamine and Levodopa Prodrugs for the Treatment of Parkinson’s Disease
Molecules, 2017 Background: Parkinson’s disease is an aggressive and progressive neurodegenerative disorder that depletes dopamine (DA) in the central nervous system.
Fatma Haddad +4 more
doaj +2 more sources
Antibacterial Prodrugs to Overcome Bacterial Resistance
Molecules, 2020 Bacterial resistance to present antibiotics is emerging at a high pace that makes the development of new treatments a must. At the same time, the development of novel antibiotics for resistant bacteria is a slow-paced process.
Rafik Karaman +2 more
exaly +2 more sources
Bioorthogonal PROTAC Prodrugs Enabled by On-Target Activation
Journal of the American Chemical Society, 2023 Although proteolysis targeting chimeras (PROTACs) have become promising therapeutic modalities, important concerns exist about the potential toxicity of the approach owning to uncontrolled degradation of proteins and undesirable ligase-mediated off ...
Mengyang Chang +5 more
semanticscholar +1 more source
The design of small-molecule prodrugs and activatable phototherapeutics for cancer therapy.
Chemical Society Reviews, 2023 Cancer remains as one of the most significant health problems, with approximately 19 million people diagnosed worldwide each year. Chemotherapy is a routinely used method to treat cancer patients.
Hai-Hao Han +10 more
semanticscholar +1 more source
Switching-on Prodrugs Using Radiotherapy
Nature Chemistry, 2021 Chemotherapy is a powerful tool in the armoury against cancer, but it is fraught with problems due to its global systemic toxicity. Here we report the proof of concept of a chemistry-based strategy, whereby gamma/X-ray irradiation mediates the activation
J. Geng +9 more
semanticscholar +1 more source
Targeting Hypoxia: Hypoxia-Activated Prodrugs in Cancer Therapy
Frontiers in Oncology, 2021 Hypoxia is an important characteristic of most solid malignancies, and is closely related to tumor prognosis and therapeutic resistance. Hypoxia is one of the most important factors associated with resistance to conventional radiotherapy and chemotherapy.
Yue Li, Long-Tao Zhao, Xiao-Feng Li
semanticscholar +1 more source
Drugs and Drug Candidates, 2023 Based on the demonstrated and reported trypanocidal, leishmanicidal, and antiplasmodial activities of two menthol prodrugs, it was decided to proceed with preformulation studies, which are of key relevance in the drug discovery process.
Camila M. Clemente +4 more
doaj +1 more source