Results 31 to 40 of about 20,922 (255)
British Journal of Pharmacy, 2023 High throughput screening (HTS) and combinatorial chemistry, have been part of the process of drug design for nearly two decades. However, methods to teach their practical aspects to undergraduate students are scarce in the literature.
Jordi Morral +3 more
doaj +1 more source
Duocarmycin-based prodrugs for cancer prodrug monotherapy
Bioorganic & Medicinal Chemistry, 2008 The synthesis and biological evaluation of novel prodrugs based on the cytotoxic antibiotic duocarmycin SA (1) for a selective treatment of cancer using a prodrug monotherapy (PMT) are described. Transformation of the phenol 8 with the glucuronic acid benzyl ester trichloroacetimidate 9b followed by reaction with DMAI x HCl (10) gives the glucuronide ...
Tietze, Lutz Friedjan +4 more
openaire +3 more sources
Molecules, 2017 One of the main obstacles for cancer therapies is to deliver medicines effectively to target sites. Since stroma cells are developed around tumors, chemotherapeutic agents have to go through stroma cells in order to reach tumors.
Yasuhiro Tsume +3 more
doaj +1 more source
Asian Journal of Pharmaceutical Sciences, 2021 Disulfide bond-bridging strategy has been extensively utilized to construct tumor specificity-responsive aliphatic prodrug nanoparticles (PNPs) for precise cancer therapy.
Yuequan Wang +10 more
doaj +1 more source
Glucocorticoids-based prodrug design: Current strategies and research progress
Asian Journal of Pharmaceutical SciencesAttributing to their broad pharmacological effects encompassing anti-inflammation, antitoxin, and immunosuppression, glucocorticoids (GCs) are extensively utilized in the clinic for the treatment of diverse diseases such as lupus erythematosus, nephritis,
Hongbing Liu +7 more
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Arhiv za Higijenu Rada i Toksikologiju, 2020 Due to their very good chemical and proteolytic stability, ability to penetrate cell membranes, and resemblance to a peptide bond, carbamate derivatives have received much attention in recent years and got an important role in modern drug discovery and ...
Matošević Ana, Bosak Anita
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FEBS Open Bio, EarlyView.The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer +7 more
wiley +1 more source
Frontiers in Bioengineering and Biotechnology, 2020 Fine-tuning loading and release of therapeutic and imaging agents associated with polymeric matrices is a fundamental step in the preclinical development of novel nanomedicines. Here, 1,000 × 400 nm Discoidal Polymeric Nanoconstructs (DPNs) were realized
Miguel Ferreira +9 more
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FEBS Open Bio, EarlyView.UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová +2 more
wiley +1 more source
Recent progress in stimuli‐activable metallo‐prodrugs for cancer therapy
Smart MoleculesThe clinical approval of platinum‐based drugs has prompted the development of novel metallo‐complexes during the last several decades, while severe problems, especially for poor water solubility, drug resistance and toxicity in patients, greatly hindered
Jinzhe Liang, Fangmian Wei, Hui Chao
doaj +1 more source