Results 31 to 40 of about 73,540 (330)
Journal of Medicinal Chemistry, 2020 Elevated levels of reactive oxygen species (ROS) have commonly been implicated in a variety of diseases, including cancer, inflammation, and neurodegenerative diseases.
Pengfei Wang +4 more
semanticscholar +1 more source
Amino Acid Prodrugs: An Approach to Improve the Absorption of HIV-1 Protease Inhibitor, Lopinavir
Pharmaceuticals, 2014 Poor systemic concentrations of lopinavir (LPV) following oral administration occur due to high cellular efflux by P-glycoprotein (P-gp) and multidrug resistance-associated proteins (MRPs) and extensive metabolism by CYP3A4 enzymes.
Mitesh Patel +4 more
doaj +1 more source
Comparison of the suppressing capecitabine and 5-fluorouracil effects on the pronounce of inflammatory cells score in the induction of episcleral fibrosis after trabeculectomy [PDF]
Vojnosanitetski Pregled, 2007 Background/Aim. Trabeculectomy is a filtering antiglaucoma surgery performed to facilitate the formation of a drainage channel for the aqueous humor from the anterior chamber of the eye to the subconjunctival space making a collector, filtering cushion ...
Milivojević Milorad +6 more
doaj +1 more source
Dolutegravir plus Two Different Prodrugs of Tenofovir to Treat HIV.
New England Journal of Medicine, 2019 BACKGROUND Two drugs under consideration for inclusion in antiretroviral therapy (ART) regimens for human immunodeficiency virus (HIV) infection are dolutegravir (DTG) and tenofovir alafenamide fumarate (TAF).
W. D. Venter +18 more
semanticscholar +1 more source
Chemical Reviews, 2016 The platinum drugs, cisplatin, carboplatin, and oxaliplatin, prevail in the treatment of cancer,, but new platinum agents have been very slow to enter the clinic. Recently, however, there has been a surge of activity, based on a great deal of mechanistic
T. Johnstone +2 more
semanticscholar +1 more source
Treatment of African Trypanosomosis with DB 75 : Pharmacokinetics, Relapses and Cross Resistance [PDF]
, 2006 Resurgent human African trypanosomosis (HAT) displays a major burden for people living in Sub-Saharan Africa, although it had been nearly eradicated in the 50`s, due to selective ground spraying with DDT and an extensive vector control.
Bernhard, Sonja Christine
core +1 more source
Prodrugs and prodrug-activated systems in gene therapy
Molecular Therapy, 2021 The inclusion of genes that control cell fate (so-called suicide, or kill-switch, genes) into gene therapy vectors is based on a compelling rationale for the safe and selective elimination of aberrant transfected cells.
Semira Sheikh, D. Ernst, A. Keating
semanticscholar +1 more source
Advanced Science, 2023 Nucleoside analogs require three phosphorylation steps catalyzed by cellular kinases to give their triphosphorylated metabolites. Herein, the synthesis of two types of triphosphate prodrugs of different nucleoside analogs is disclosed.
Xiao Jia, Dominique Schols, Chris Meier
doaj +1 more source
Photoactivatable Caged Prodrugs of VEGFR-2 Kinase Inhibitors
Molecules, 2016 In this study, we report on the design, synthesis, photokinetic properties and in vitro evaluation of photoactivatable caged prodrugs for the receptor tyrosine kinase VEGFR-2.
Boris Pinchuk +4 more
doaj +1 more source
Cyclooxygenase-Inhibiting Platinum(IV) Prodrugs with Potent Anticancer Activity
Pharmaceutics, 2022 Platinum(IV) prodrugs of the [Pt(PL)(AL)(COXi)(OH)]2+ type scaffold (where PL is 1,10-phenanthroline or 5,6-dimethyl-1,10-phenanthroline, AL is 1S,2S-diaminocyclohexane, and COXi is a COX inhibitor, either indomethacin or aspirin) were synthesised and ...
Aleen Khoury +6 more
doaj +1 more source