Results 21 to 30 of about 73,540 (330)
Engineering of small-molecule lipidic prodrugs as novel nanomedicines for enhanced drug delivery
Journal of Nanobiotechnology, 2022 A widely established prodrug strategy can effectively optimize the unappealing properties of therapeutic agents in cancer treatment. Among them, lipidic prodrugs extremely uplift the physicochemical properties, site-specificity, and antitumor activities ...
Lingling Huang +4 more
semanticscholar +1 more source
Tyrosinase activated melanoma prodrugs
, 2009 Metastatic malignant melanoma remains a highly aggressive form of skin cancer for which no reliable methods for treatment exist. Given the increasing incidence of this cancer, considerable attention has focused on the development of new and improved ...
Jawaid, Samaila +3 more
core +9 more sources
Ligand Evolution in the Photoactivatable Platinum(IV) Anticancer Prodrugs
Frontiers in Chemistry, 2022 Photoactivatable Pt(IV) anticancer prodrugs with the structure of [PtIV(N1)(N2)(L1)(L2)(A1)(A2)], where N1 and N2 are non-leaving nitrogen donor ligands, L1 and L2 are leaving ligands, and A1 and A2 are axial ligands, have attracted increasing attention ...
Jingjing Huang +9 more
doaj +1 more source
Phosphonates and Phosphonate Prodrugs in Medicinal Chemistry: Past Successes and Future Prospects
Frontiers in Chemistry, 2022 Compounds with a phosphonate group, i.e., –P(O)(OH)2 group attached directly to the molecule via a P-C bond serve as suitable non-hydrolyzable phosphate mimics in various biomedical applications. In principle, they often inhibit enzymes utilizing various
M. Krečmerová +3 more
semanticscholar +1 more source
Glycosidase activated prodrugs for targeted cancer therapy.
Chemical Society Reviews, 2022 In this review glycosidase activated prodrugs that target cancer cells are discussed. Glycosylated prodrugs undergo enzymatic bioconversion, cleaving the prodrug to release the anticancer drug at the desired site of action, hence minimising the toxic ...
Harlei Martin +3 more
semanticscholar +1 more source
Activation and Delivery of Tetrazine-Responsive Bioorthogonal Prodrugs
Molecules, 2020 Prodrugs, which remain inert until they are activated under appropriate conditions at the target site, have emerged as an attractive alternative to drugs that lack selectivity and show off-target effects.
Yayue Wang +3 more
doaj +1 more source
Journal of Advanced Research, 2017 Prodrugs, the inert derivatives of existing drugs have successfully contributed to the modification of their physicochemical properties. The improved antimicrobial potential due to enhanced lipophilicity of some of the synthesized prodrugs of ...
Mona Piplani +2 more
doaj +1 more source
Increased/Targeted Brain (Pro)Drug Delivery via Utilization of Solute Carriers (SLCs)
Pharmaceutics, 2022 Membrane transporters have a crucial role in compounds’ brain drug delivery. They allow not only the penetration of a wide variety of different compounds to cross the endothelial cells of the blood–brain barrier (BBB), but also the accumulation of them ...
Johanna Huttunen +3 more
doaj +1 more source
Aryl phosphoramidates of 5-phospho erythronohydroxamic acid, a new class of potent Trypanocidal compounds [PDF]
, 2010 RNAi and enzymatic studies have shown the importance of 6-phosphogluconate dehydrogenase (6-PGDH) in Trypanosoma brucei for the parasite survival and make it an attractive drug target for the development of new treatments against human African ...
Ruda, Gian Filippo +20 more
core +1 more source
Molecules, 2022 In past decades, anticancer research has led to remarkable results despite many of the approved drugs still being characterized by high systemic toxicity mainly due to the lack of tumor selectivity and present pharmacokinetic drawbacks, including low ...
Giuseppina Ioele +6 more
doaj +1 more source