Results 21 to 30 of about 33,100 (295)
Amino Acid Prodrugs: An Approach to Improve the Absorption of HIV-1 Protease Inhibitor, Lopinavir
Pharmaceuticals, 2014 Poor systemic concentrations of lopinavir (LPV) following oral administration occur due to high cellular efflux by P-glycoprotein (P-gp) and multidrug resistance-associated proteins (MRPs) and extensive metabolism by CYP3A4 enzymes.
Mitesh Patel +4 more
doaj +1 more source
Comparison of the suppressing capecitabine and 5-fluorouracil effects on the pronounce of inflammatory cells score in the induction of episcleral fibrosis after trabeculectomy [PDF]
Vojnosanitetski Pregled, 2007 Background/Aim. Trabeculectomy is a filtering antiglaucoma surgery performed to facilitate the formation of a drainage channel for the aqueous humor from the anterior chamber of the eye to the subconjunctival space making a collector, filtering cushion ...
Milivojević Milorad +6 more
doaj +1 more source
Molecules, 2008 Parkinson`s disease (PD) is a progressive, neurodegenerative disorder whichinvolves the loss of dopaminergic neurons of the substantia nigra pars compacta. Currenttherapy is essentially symptomatic, and L-Dopa (LD), the direct precursor of dopamine(DA), is the treatment of choice in more advanced stages of the disease.
DI STEFANO, Antonio +2 more
openaire +4 more sources
Photoactivatable Caged Prodrugs of VEGFR-2 Kinase Inhibitors
Molecules, 2016 In this study, we report on the design, synthesis, photokinetic properties and in vitro evaluation of photoactivatable caged prodrugs for the receptor tyrosine kinase VEGFR-2.
Boris Pinchuk +4 more
doaj +1 more source
Advanced Science, 2023 Nucleoside analogs require three phosphorylation steps catalyzed by cellular kinases to give their triphosphorylated metabolites. Herein, the synthesis of two types of triphosphate prodrugs of different nucleoside analogs is disclosed.
Xiao Jia, Dominique Schols, Chris Meier
doaj +1 more source
Molecular Therapy: Nucleic Acids, 2013 MGH2.1 is a herpes simplex virus type 1 (HSV1) oncolytic virus that expresses two prodrug-activating transgenes: the cyclophosphamide (CPA)-activating cytochrome P4502B1 (CYP2B1) and the CPT11-activating secreted human intestinal carboxylesterase (shiCE).
Kazue Kasai +9 more
doaj +1 more source
Cyclooxygenase-Inhibiting Platinum(IV) Prodrugs with Potent Anticancer Activity
Pharmaceutics, 2022 Platinum(IV) prodrugs of the [Pt(PL)(AL)(COXi)(OH)]2+ type scaffold (where PL is 1,10-phenanthroline or 5,6-dimethyl-1,10-phenanthroline, AL is 1S,2S-diaminocyclohexane, and COXi is a COX inhibitor, either indomethacin or aspirin) were synthesised and ...
Aleen Khoury +6 more
doaj +1 more source
Can the Union of Prodrug Therapy and Nanomedicine Lead to Better Cancer Management?
Advanced NanoBiomed Research, 2022 Prodrug‐mediated and nanomedicine‐mediated therapies stand at the forefront of cancer management today. However, a lot of recent research efforts have been focused on identifying novel strategies in treating tumor by combining the techniques and ...
Giredhar Muthiah, Amit Jaiswal
doaj +1 more source
Frontiers in Pharmacology, 2023 Immune-stimulating antibody conjugates (ISACs) equipped with imidazoquinoline (IMD) payloads can stimulate endogenous immune cells to kill cancer cells, ultimately inducing long-lasting anticancer effects.
Lydia Bisbal Lopez +15 more
doaj +1 more source
Viruses, 2023 Over the past decades, both 4′-modified nucleoside and carbocyclic nucleoside analogs have been under the spotlight as several compounds from either family showed anti-HIV, HCV, RSV or SARS-CoV-2 activity.
Nicolas G. Biteau +8 more
doaj +1 more source