Results 1 to 10 of about 65,300 (300)

Modern Prodrug Design for Targeted Oral Drug Delivery

Molecules, 2014
The molecular information that became available over the past two decades significantly influenced the field of drug design and delivery at large, and the prodrug approach in particular.
Arik Dahan, Shimon Ben-Shabat, Ellen M Zimmermann   +2 more
exaly   +4 more sources

Impact of the amount of PEG on prodrug nanoassemblies for efficient cancer therapy

Asian Journal of Pharmaceutical Sciences, 2022
PEGylation has been widely used to improve the pharmacokinetic properties of prodrug self-assembled nanoparticles (prodrug-SANPs). However, the impacts of the amount of PEG on the self-assemble stability, cellular uptake, pharmacokinetics, and antitumor ...
Yaqiao Li, Jin Sun, Yongjun Wang
exaly   +3 more sources

Stimuli-responsive prodrug-based cancer nanomedicine

EBioMedicine, 2020
The rapid development of nanotechnology results in the emergence of nanomedicines, but the effective delivery of drugs to tumor sites remains a great challenge.
Sumaira Hanif, Jiang Ouyang, Zhongmin Tang   +2 more
exaly   +3 more sources

Tumor-overexpressed enzyme responsive amphiphiles small molecular self-assembly nano-prodrug for the chemo-phototherapy against non-small-cell lung cancer

Materials Today Bio, 2023
Rational design of self-assembly drug amphiphiles can provide a promising strategy for constructing nano-prodrug with high drug loading, smart stimuli-responsive drug release and high tumor selectivity.
Peilian Liu, Yong Huang, Chenyue Zhan, Fu Zhang, Chuansen Deng, Yongmei Jia, Tao Wan, Sheng Wang, Bowen Li   +8 more
doaj   +1 more source

A Co-delivery System Based on a Dimeric Prodrug and Star-Shaped Polymeric Prodrug Micelles for Drug Delivery

Frontiers in Chemistry, 2021
Chemotherapy is one of the commonly used therapies for the treatment of malignant tumors. Insufficient drug-loading capacity is the major challenge for polymeric micelle–based drug delivery systems of chemotherapy.
Man Zhou, Man Zhou, Yan Luo, Yan Luo, Weijia Zeng, Xiaoqing Yang, Tingting Chen, Lulu Zhang, Xiaoyan He, Xiuguang Yi, Yongxiu Li, Xiaoqing Yi   +11 more
doaj   +1 more source

Synthesis and evaluation of hydrogen peroxide sensitive tofacitinib prodrugs

European Journal of Medicinal Chemistry Reports, 2022
Tofacitinib (CP-690,550), an approved Janus kinase (JAK) inhibitor, has been proven highly efficacious in treating rheumatoid arthritis (RA). Unfortunately, tofacitinib's clinical application has been limited by adverse side effects that arise from its ...
Viola Previtali, Ulrik Bering Keiding, Asger Hegelund Olsen, Jorge Peiró Cadahía, Anne Skovsbo Clausen, Andreas Kjaer, Thomas Lars Andresen, Anders Elias Hansen, Mads Hartvig Clausen   +8 more
doaj   +1 more source

Design, Synthesis, and In Vitro Evaluation of the Photoactivatable Prodrug of the PARP Inhibitor Talazoparib

Molecules, 2020
In this article, we report the design, synthesis, photodynamic properties, and in vitro evaluation of photoactivatable prodrug for the poly (ADP-ribose) polymerase 1 (PARP-1) inhibitor Talazoparib.
Jiaguo Li, Dian Xiao, Lianqi Liu, Fei Xie, Wei Li, Wei Sun, Xiaohong Yang, Xinbo Zhou   +7 more
doaj   +1 more source

Pró-fármaco ativado por enzima, uma estratégia promissora na quimioterapia

Química Nova, 2006
Strategies that promote selective activation of prodrugs by enzymes can be divided into two major classes: 1) deliver of a monoclonal antibody-enzyme immunoconjugate that can recognize a specific antigen and promote the prodrug to a citotoxic drug, with ...
Lorena Blau, Renato Farina Menegon, Man Chin Chung   +2 more
doaj   +1 more source

Targeted Methotrexate Prodrug Conjugated With Heptamethine Cyanine Dye Improving Chemotherapy and Monitoring Itself Activating by Dual-Modal Imaging

Frontiers in Materials, 2018
Theranostic prodrug plays a vital role in reducing the side effects and evaluating the therapeutic efficiency of prodrug in vivo. In particular, small conjugate-based theranostic prodrugs have attracted much attention because of their clear and simple ...
Sanpeng Li, Sanpeng Li, Zhihong Sun, Xiaoqing Meng, Xiaoqing Meng, Guanjun Deng, Guanjun Deng, Jiali Zhang, Jiali Zhang, Kui Zhou, Wenjun Li, Lihua Zhou, Ping Gong, Ping Gong, Lintao Cai   +14 more
doaj   +1 more source

Protocol for evaluating the abilities of diverse nitroaromatic prodrug metabolites to exit a model Gram negative bacterial vector

MethodsX, 2020
Bacterial-directed enzyme-prodrug therapy (BDEPT) uses tumour-tropic bacteria armed with a genetically-encoded prodrug-converting enzyme to sensitise tumours to a systemically-administered prodrug.
Jasmine V.E. Chan-Hyams, David F. Ackerley   +1 more
doaj   +1 more source