Nitroreductase-triggered indazole formation [PDF]
Nature CommunicationsBiocatalysis contributes significantly to the development of more sustainable synthetic pathways by using mild reaction conditions and water as a solvent.
Henrik Terholsen +5 more
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A Globally Distributed Cyanobacterial Nitroreductase Capable of Conferring Biodegradation of Chloramphenicol [PDF]
ResearchCyanobacteria play pivotal roles in global biogeochemical cycles and aquatic ecosystems due to their widespread distribution and significant contributions to primary production.
Qiu-Lian Zhong, Jiu-Qiang Xiong
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Functions of nitroreductases in mycobacterial physiology and drug susceptibility [PDF]
Journal of BacteriologyTuberculosis is a respiratory infection that is caused by members of the Mycobacterium tuberculosis complex, with M. tuberculosis (Mtb) being the predominant cause of the disease in humans.
Ifeanyichukwu E. Eke +1 more
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The NTR/prodrug revolution: Tools for controlling cell loss and regeneration [PDF]
eLifeHere, we review the history, advancements, and broad utility of the NTR/prodrug system, and suggest future strategies for developing versatile ablation models. As a chemogenetic tool, the nitroreductase (NTR)/prodrug system enables precise spatiotemporal
Gha-Hyun J Kim, Michael Parsons
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The YfkO Nitroreductase from Bacillus Licheniformis on Gold-Coated Superparamagnetic Nanoparticles: Towards a Novel Directed Enzyme Prodrug Therapy Approach [PDF]
Pharmaceutics, 2021 The bacterial nitroreductase NfnB has been the focus of a great deal of research for its use in directed enzyme prodrug therapy in combination with the nitroreductase prodrug CB1954 with this combination of enzyme and prodrug even entering clinical ...
Patrick Ball +6 more
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Safety Evaluation of Weissella paramesenteroides MW-142 Isolated From Traditional Fermented Mulberry Wine. [PDF]
MicrobiologyopenIntegrated safety evaluation of Weissella paramesenteroides MW‐142 from traditional fermented mulberry wine demonstrates no acute oral toxicity, non‐hemolytic activity, absence of harmful metabolites, and only intrinsic, non‐mobile antibiotic resistance genes, supporting its potential as a safe candidate for probiotic or biopreservative applications ...
Huang J +6 more
europepmc +2 more sources
Recent advances and applications of nitroreductase activable agents for tumor theranostic [PDF]
Frontiers in PharmacologyNitroreductase activable agents offer a personalized and targeted approach to cancer theranostics by selectively activating prodrugs within the tumor microenvironment.
Baoxin Shang +4 more
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Real‐Time Detection of Reduced Nitroreductase with a Reversible Fluorescent Probe [PDF]
Advanced ScienceNitroreductase (NTR), a class of flavin‐dependent redox enzymes, is a key biomarker for hypoxic tumors. Numerous fluorescent NTR probes have been developed to study hypoxia and associated tumors; however, they are reaction‐based and provide only static ...
Sourav Sarkar +8 more
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Gut microbial metabolism of Flutamide attenuates its therapeutic efficacy against prostate cancer [PDF]
Gut MicrobesEndocrine drugs serve as the cornerstone of prostate cancer treatment. Flutamide, a representative first-generation antiandrogen, has been relegated to the treatment of recurrent prostate cancer due to novel drug development and therapeutic resistance ...
Shujing Li +17 more
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In situ identifying sennoside A-reducing bacteria guilds in human gut microbiota via enzymatic activity visualization [PDF]
Gut MicrobesThe intestinal environment determines the biochemical activity of individual microbial strains. The functions of microbial strains in their native environments often cannot be accurately predicted based solely on genomic information or the biochemical ...
Chuanjia Zhai +12 more
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