Results 1 to 10 of about 6,658 (162)

The NTR/prodrug revolution: Tools for controlling cell loss and regeneration [PDF]

eLife
Here, we review the history, advancements, and broad utility of the NTR/prodrug system, and suggest future strategies for developing versatile ablation models. As a chemogenetic tool, the nitroreductase (NTR)/prodrug system enables precise spatiotemporal
Gha-Hyun J Kim, Michael Parsons
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Use of nfsB, encoding nitroreductase, as a reporter gene to determine the mutational spectrum of spontaneous mutations in Neisseria gonorrhoeae [PDF]

BMC Microbiology, 2009
Background Organisms that are sensitive to nitrofurantoin express a nitroreductase. Since bacterial resistance to this compound results primarily from mutations in the gene encoding nitroreductase, the resulting loss of function of nitroreductase results
Dunham Stephen, Carrizosa Esteban, Stein Daniel C   +2 more
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A Novel NIR Fluorescent Probe for Highly Selective Detection of Nitroreductase and Hypoxic-Tumor-Cell Imaging

Molecules, 2021
Nitroreductase as a potential biomarker for aggressive tumors has received extensive attention. In this work, a novel NIR fluorescent probe for nitroreductase detection was synthesized.
Feng Liu, Hong Zhang, Kun Li, Yongmei Xie, Zhihui Li   +4 more
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Real‐Time Detection of Reduced Nitroreductase with a Reversible Fluorescent Probe [PDF]

Advanced Science
Nitroreductase (NTR), a class of flavin‐dependent redox enzymes, is a key biomarker for hypoxic tumors. Numerous fluorescent NTR probes have been developed to study hypoxia and associated tumors; however, they are reaction‐based and provide only static ...
Sourav Sarkar, Anushree Shil, Yong Woong Jun, Yun Jae Yang, Ranran Cheng, Wenli Wu, Xuechen Li, Qiongzheng Hu, Kyo Han Ahn   +8 more
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Nitroreductase-triggered indazole formation [PDF]

Nature Communications
Biocatalysis contributes significantly to the development of more sustainable synthetic pathways by using mild reaction conditions and water as a solvent.
Henrik Terholsen, Lisa Medema, Elizaveta Chernyshova, Alejandro Prats Luján, Gerrit J. Poelarends, Sandy Schmidt   +5 more
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The YfkO Nitroreductase from Bacillus Licheniformis on Gold-Coated Superparamagnetic Nanoparticles: Towards a Novel Directed Enzyme Prodrug Therapy Approach

Pharmaceutics, 2021
The bacterial nitroreductase NfnB has been the focus of a great deal of research for its use in directed enzyme prodrug therapy in combination with the nitroreductase prodrug CB1954 with this combination of enzyme and prodrug even entering clinical ...
Patrick Ball, Robert Hobbs, Simon Anderson, Emma Thompson, Vanessa Gwenin, Christopher Von Ruhland, Christopher Gwenin   +6 more
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Anti-Trypanosoma cruzi Activity, Mutagenicity, Hepatocytotoxicity and Nitroreductase Enzyme Evaluation of 3-Nitrotriazole, 2-Nitroimidazole and Triazole Derivatives

Molecules, 2023
Chagas disease (CD), which is caused by Trypanosoma cruzi and was discovered more than 100 years ago, remains the leading cause of death from parasitic diseases in the Americas.
Cheyene Almeida Celestino Menozzi, Rodolfo Rodrigo Florido França, Pedro Henrique Luccas, Mayara dos Santos Baptista, Tácio Vinício Amorim Fernandes, Lucas Villas Bôas Hoelz, Policarpo Ademar Sales Junior, Silvane Maria Fonseca Murta, Alvaro Romanha, Bárbara Verena Dias Galvão, Marcela de Oliveira Macedo, Alana da Cunha Goldstein, Carlos Fernando Araujo-Lima, Israel Felzenszwalb, Maria Cristina Nonato, Frederico Silva Castelo-Branco, Nubia Boechat   +16 more
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Effect of Reduced Tillage on Soil Enzyme Activity, Pests Pressure and Productivity of Organically Grown Spring Wheat Species

Agronomy, 2023
The possibility of using reduced tillage in organic farming is poorly recognized. The study aimed to assess the impact of the tillage method (shallow tillage and plowing) on soil biochemical activity, pest pressure, and grain yield of Triticum ...
Małgorzata Szczepanek, Anetta Siwik-Ziomek, Grzegorz Lemańczyk, Robert Lamparski, Radomir Graczyk   +4 more
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RETRACTED: An acridone-derived fluorescent off-on probe for detection and in vivo imaging of nitroreductase

Frontiers in Materials, 2023
Understanding the functions of enzymes in various physiological processes is important, but the design of signaling probes for fast analysis of enzymatic activity is particularly challenging.
Meicen Liu, Guanyu Chen, Guanyu Chen, Lilan Xu, Lilan Xu, Tingting Chen, Tingting Chen, Wenqian Chen, Wenqian Chen, Jinghua Chen, Jinghua Chen, Xi Zhang   +11 more
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CpxA/R‐Controlled Nitroreductase Expression as Target for Combinatorial Therapy against Uropathogens by Promoting Reactive Oxygen Species Generation

Advanced Science, 2023
The antibiotic resistances emerged in uropathogens lead to accumulative treatment failure and recurrent episodes of urinary tract infection (UTI), necessitating more innovative therapeutics to curb UTI before systematic infection.
Hao Ren, Zixing Zhong, Shuang Zhou, Yiyang Wei, Yujiao Liang, Huiling He, Zijian Zheng, Mengyuan Li, Qian He, Tengfei Long, Xinlei Lian, Xiaoping Liao, Yahong Liu, Jian Sun   +13 more
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