Results 1 to 10 of about 6,542 (200)

Identification of Enterococcus faecalis enzymes with azoreductases and/or nitroreductase activity

BMC Microbiology, 2017
Background Nitroreductases, NAD(P)H dependent flavoenzymes, are found in most of bacterial species. Even if Enterococcus faecalis strains seems to present such activity because of their sensitivity to nitrofurans, no enzyme has been described ...
Valérie Chalansonnet, Claire Mercier, Sylvain Orenga, Christophe Gilbert   +3 more
doaj   +2 more sources

The YfkO Nitroreductase from Bacillus Licheniformis on Gold-Coated Superparamagnetic Nanoparticles: Towards a Novel Directed Enzyme Prodrug Therapy Approach

Pharmaceutics, 2021
The bacterial nitroreductase NfnB has been the focus of a great deal of research for its use in directed enzyme prodrug therapy in combination with the nitroreductase prodrug CB1954 with this combination of enzyme and prodrug even entering clinical ...
Patrick Ball, Robert Hobbs, Simon Anderson, Emma Thompson, Vanessa Gwenin, Christopher Von Ruhland, Christopher Gwenin   +6 more
doaj   +1 more source

Anti-Trypanosoma cruzi Activity, Mutagenicity, Hepatocytotoxicity and Nitroreductase Enzyme Evaluation of 3-Nitrotriazole, 2-Nitroimidazole and Triazole Derivatives

Molecules, 2023
Chagas disease (CD), which is caused by Trypanosoma cruzi and was discovered more than 100 years ago, remains the leading cause of death from parasitic diseases in the Americas.
Cheyene Almeida Celestino Menozzi, Rodolfo Rodrigo Florido França, Pedro Henrique Luccas, Mayara dos Santos Baptista, Tácio Vinício Amorim Fernandes, Lucas Villas Bôas Hoelz, Policarpo Ademar Sales Junior, Silvane Maria Fonseca Murta, Alvaro Romanha, Bárbara Verena Dias Galvão, Marcela de Oliveira Macedo, Alana da Cunha Goldstein, Carlos Fernando Araujo-Lima, Israel Felzenszwalb, Maria Cristina Nonato, Frederico Silva Castelo-Branco, Nubia Boechat   +16 more
doaj   +1 more source

Effect of Reduced Tillage on Soil Enzyme Activity, Pests Pressure and Productivity of Organically Grown Spring Wheat Species

Agronomy, 2023
The possibility of using reduced tillage in organic farming is poorly recognized. The study aimed to assess the impact of the tillage method (shallow tillage and plowing) on soil biochemical activity, pest pressure, and grain yield of Triticum ...
Małgorzata Szczepanek, Anetta Siwik-Ziomek, Grzegorz Lemańczyk, Robert Lamparski, Radomir Graczyk   +4 more
doaj   +1 more source

RETRACTED: An acridone-derived fluorescent off-on probe for detection and in vivo imaging of nitroreductase

Frontiers in Materials, 2023
Understanding the functions of enzymes in various physiological processes is important, but the design of signaling probes for fast analysis of enzymatic activity is particularly challenging.
Meicen Liu, Guanyu Chen, Guanyu Chen, Lilan Xu, Lilan Xu, Tingting Chen, Tingting Chen, Wenqian Chen, Wenqian Chen, Jinghua Chen, Jinghua Chen, Xi Zhang   +11 more
doaj   +1 more source

CpxA/R‐Controlled Nitroreductase Expression as Target for Combinatorial Therapy against Uropathogens by Promoting Reactive Oxygen Species Generation

Advanced Science, 2023
The antibiotic resistances emerged in uropathogens lead to accumulative treatment failure and recurrent episodes of urinary tract infection (UTI), necessitating more innovative therapeutics to curb UTI before systematic infection.
Hao Ren, Zixing Zhong, Shuang Zhou, Yiyang Wei, Yujiao Liang, Huiling He, Zijian Zheng, Mengyuan Li, Qian He, Tengfei Long, Xinlei Lian, Xiaoping Liao, Yahong Liu, Jian Sun   +13 more
doaj   +1 more source

Use of nfsB, encoding nitroreductase, as a reporter gene to determine the mutational spectrum of spontaneous mutations in Neisseria gonorrhoeae

BMC Microbiology, 2009
Background Organisms that are sensitive to nitrofurantoin express a nitroreductase. Since bacterial resistance to this compound results primarily from mutations in the gene encoding nitroreductase, the resulting loss of function of nitroreductase results
Dunham Stephen, Carrizosa Esteban, Stein Daniel C   +2 more
doaj   +1 more source

Trypanocidal Activity of Flavanone Derivatives

Molecules, 2020
Chagas disease, also known as American trypanosomiasis, is classified as a neglected disease by the World Health Organization. For clinical treatment, only two drugs have been on the market, Benznidazole and Nifurtimox, both of which are recommended for ...
Gabriela Maciel Diogo, Josimara Souza Andrade, Policarpo Ademar Sales Junior, Silvane Maria Fonseca Murta, Viviane Martins Rebello Dos Santos, Jason Guy Taylor   +5 more
doaj   +1 more source

A Novel NIR Fluorescent Probe for Highly Selective Detection of Nitroreductase and Hypoxic-Tumor-Cell Imaging

Molecules, 2021
Nitroreductase as a potential biomarker for aggressive tumors has received extensive attention. In this work, a novel NIR fluorescent probe for nitroreductase detection was synthesized.
Feng Liu, Hong Zhang, Kun Li, Yongmei Xie, Zhihui Li   +4 more
doaj   +1 more source

5-Nitrofuran-Tagged Oxazolyl Pyrazolopiperidines: Synthesis and Activity against ESKAPE Pathogens

Molecules, 2023
A series of eight 5-nitrofuran-tagged oxazolyl tetrahydropyrazolopyridines (THPPs) has been prepared in six stages with excellent regioselectivity.
Elizaveta Rogacheva, Lyudmila Kraeva, Alexey Lukin, Lyubov Vinogradova, Kristina Komarova, Mikhail Chudinov, Maxim Gureev, Evgeny Chupakhin   +7 more
doaj   +1 more source