Results 11 to 20 of about 6,542 (200)
Nitroreductase-triggered indazole formation [PDF]
Nature CommunicationsBiocatalysis contributes significantly to the development of more sustainable synthetic pathways by using mild reaction conditions and water as a solvent.
Henrik Terholsen +5 more
doaj +8 more sources
Nitroreductase Activites in Giardia lamblia: ORF 17150 Encodes a Quinone Reductase with Nitroreductase Activity [PDF]
Pathogens, 2021 The intestinal diplomonadid Giardia lamblia is a causative agent of persistent diarrhea. Current treatments are based on nitro drugs, especially metronidazole. Nitro compounds are activated by reduction, yielding toxic intermediates.
Joachim Müller +4 more
doaj +6 more sources
Trigeminal and facial branchiomotor neurons have shared muscle targets in zebrafish larvae [PDF]
Journal of Anatomy, EarlyView.Cranial nerve innervation map, based on previous studies, shows the trigeminal and facial motor nerves confined to the mandibular and hyoid arch muscles, respectively, except for the trigeminal nerve in the interhyoideus muscle (M.IH). The revised cranial nerve innervation map, based on this study, shows the facial nerve in the intermandibularis ...
Ritika Ghosal +2 more
wiley +2 more sources
The NTR/prodrug revolution: Tools for controlling cell loss and regeneration [PDF]
eLifeHere, we review the history, advancements, and broad utility of the NTR/prodrug system, and suggest future strategies for developing versatile ablation models. As a chemogenetic tool, the nitroreductase (NTR)/prodrug system enables precise spatiotemporal
Gha-Hyun J Kim, Michael Parsons
doaj +2 more sources
NTO Degradation by Nitroreductase: A DFT Study
The Journal of Physical Chemistry B, 2022 NTO (5-nitro-1,2,4-triazol-3-one), an energetic material used in military applications, may be released to the environment during manufacturing, transportation, storage, training, and disposal. A detailed investigation of the possible mechanism for all steps of reduction of NTO by oxygen-insensitive nitroreductase, as one of the pathways for NTO ...
Liudmyla K. Sviatenko +2 more
openaire +3 more sources
ResearchCyanobacteria play pivotal roles in global biogeochemical cycles and aquatic ecosystems due to their widespread distribution and significant contributions to primary production.
Qiu-Lian Zhong, Jiu-Qiang Xiong
doaj +2 more sources
Real‐Time Detection of Reduced Nitroreductase with a Reversible Fluorescent Probe [PDF]
Advanced ScienceNitroreductase (NTR), a class of flavin‐dependent redox enzymes, is a key biomarker for hypoxic tumors. Numerous fluorescent NTR probes have been developed to study hypoxia and associated tumors; however, they are reaction‐based and provide only static ...
Sourav Sarkar +8 more
doaj +2 more sources
Functions of nitroreductases in mycobacterial physiology and drug susceptibility [PDF]
Journal of BacteriologyTuberculosis is a respiratory infection that is caused by members of the Mycobacterium tuberculosis complex, with M. tuberculosis (Mtb) being the predominant cause of the disease in humans.
Ifeanyichukwu E. Eke +1 more
doaj +2 more sources
A mammalianized synthetic nitroreductase gene for high-level expression [PDF]
BMC Cancer, 2009 Background The nitroreductase/5-(azaridin-1-yl)-2,4-dinitrobenzamide (NTR/CB1954) enzyme/prodrug system is considered as a promising candidate for anti-cancer strategies by gene-directed enzyme prodrug therapy (GDEPT) and has recently entered clinical ...
Grohmann Maik +5 more
doaj +3 more sources
The Role of Nitroreductases in Resistance to Nitroimidazoles [PDF]
Biology, 2021 Antimicrobial resistance is a major challenge facing modern medicine, with an estimated 700,000 people dying annually and a global cost in excess of $100 trillion. This has led to an increased need to develop new, effective treatments. This review focuses on nitroimidazoles, which have seen a resurgence in interest due to their broad spectrum of ...
Carol Thomas, Christopher D. Gwenin
openaire +3 more sources