Results 11 to 20 of about 5,837 (209)

Nitroreductase Activites in Giardia lamblia: ORF 17150 Encodes a Quinone Reductase with Nitroreductase Activity [PDF]

Pathogens, 2021
The intestinal diplomonadid Giardia lamblia is a causative agent of persistent diarrhea. Current treatments are based on nitro drugs, especially metronidazole. Nitro compounds are activated by reduction, yielding toxic intermediates.
Joachim Müller, Manfred Heller, Anne-Christine Uldry, Sophie Braga, Norbert Müller   +4 more
doaj   +5 more sources

Quinone- and nitroreductase reactions of Thermotoga maritima peroxiredoxin–nitroreductase hybrid enzyme [PDF]

Archives of Biochemistry and Biophysics, 2012
Thermotoga maritima peroxiredoxin-nitroreductase hybrid enzyme (Prx-NR) consists of a FMN-containing nitroreductase (NR) domain fused to a peroxiredoxin (Prx) domain. These domains seem to function independently as no electron transfer occurs between them.
Žilvinas, Anusevičius, Lina, Misevičienė, Jonas, Šarlauskas, Nicolas, Rouhier, Jean-Pierre, Jacquot, Narimantas, Čėnas   +5 more
core   +4 more sources

NTO Degradation by Nitroreductase: A DFT Study

The Journal of Physical Chemistry B, 2022
NTO (5-nitro-1,2,4-triazol-3-one), an energetic material used in military applications, may be released to the environment during manufacturing, transportation, storage, training, and disposal. A detailed investigation of the possible mechanism for all steps of reduction of NTO by oxygen-insensitive nitroreductase, as one of the pathways for NTO ...
Liudmyla K. Sviatenko, Leonid Gorb, Jerzy Leszczynski   +2 more
openaire   +3 more sources

Identification of Enterococcus faecalis enzymes with azoreductases and/or nitroreductase activity

BMC Microbiology, 2017
Background Nitroreductases, NAD(P)H dependent flavoenzymes, are found in most of bacterial species. Even if Enterococcus faecalis strains seems to present such activity because of their sensitivity to nitrofurans, no enzyme has been described ...
Valérie Chalansonnet, Claire Mercier, Sylvain Orenga, Christophe Gilbert   +3 more
doaj   +2 more sources

Engineering the Escherichia coli Nitroreductase NfsA to Create a Flexible Enzyme-Prodrug Activation System

Frontiers in Pharmacology, 2021
Bacterial nitroreductase enzymes that can efficiently convert nitroaromatic prodrugs to a cytotoxic form have numerous applications in targeted cellular ablation. For example, the generation of cytotoxic metabolites that have low bystander potential (i.e.
Abigail V. Sharrock, Abigail V. Sharrock, Abigail V. Sharrock, Sarah P. McManaway, Michelle H. Rich, Jeff S. Mumm, Ian F. Hermans, Ian F. Hermans, Ian F. Hermans, Moana Tercel, Moana Tercel, Frederik B. Pruijn, Frederik B. Pruijn, David F. Ackerley, David F. Ackerley, David F. Ackerley   +15 more
doaj   +2 more sources

Investigating the application of a nitroreductase-expressing transgenic zebrafish line for high-throughput toxicity testing

Toxicology Reports, 2017
Nitroreductase enzymes are responsible for the reduction of nitro functional groups to amino functional groups, and are found in a range of animal models, zebrafish (Danio rerio) excluded.
Anna C. Chlebowski, Jane K. La Du, Lisa Truong, Staci L. Massey Simonich, Robert L. Tanguay   +4 more
doaj   +2 more sources

A mammalianized synthetic nitroreductase gene for high-level expression [PDF]

BMC Cancer, 2009
Background The nitroreductase/5-(azaridin-1-yl)-2,4-dinitrobenzamide (NTR/CB1954) enzyme/prodrug system is considered as a promising candidate for anti-cancer strategies by gene-directed enzyme prodrug therapy (GDEPT) and has recently entered clinical ...
Grohmann Maik, Paulmann Nils, Fleischhauer Sebastian, Vowinckel Jakob, Priller Josef, Walther Diego J   +5 more
doaj   +3 more sources

Confirmation of Frm2 as a novel nitroreductase in Saccharomyces cerevisiae

Biochemical and Biophysical Research Communications, 2012
Nitroreductases comprise a group of FMN- or FAD-dependent enzymes that reduce nitrosubstituted compounds by using NAD(P)H, and are found in bacterial species and yeast. Although there is little information on the biological functions of nitroreductases, some studies suggest their possible involvement in oxidative stress responses.
Seo Young, Bang, Jeong Hoon, Kim, Phil Young, Lee, Kwang-Hee, Bae, Jong Suk, Lee, Pan-Soo, Kim, Do Hee, Lee, Pyung Keun, Myung, Byoung Chul, Park, Sung Goo, Park   +9 more
openaire   +3 more sources

Phytodetoxification of TNT by transgenic plants expressing a bacterial nitroreductase

Nature Biotechnology, 2001
There is major international concern over the wide-scale contamination of soil and associated ground water by persistent explosives residues. 2,4,6-Trinitrotoluene (TNT) is one of the most recalcitrant and toxic of all the military explosives.
Hannink, N., Rosser, S.J., French, C.E., Basran, A., Murray, J.A.H., Nicklin, S., Bruce, N.C.   +6 more
openaire   +4 more sources

Nitroreductase catalyzed biotransformation of CL-20

Biochemical and Biophysical Research Communications, 2004
Previously, we reported that a salicylate 1-monooxygenase from Pseudomonas sp. ATCC 29352 biotransformed CL-20 (2,4,6,8,10,12-hexanitro-2,4,6,8,10,12-hexaaza-isowurtzitane) (C(6)H(6)N(12)O(12)) and produced a key metabolite with mol. wt. 346 Da corresponding to an empirical formula of C(6)H(6)N(10)O(8) which spontaneously decomposed in aqueous medium ...
Bhushan, Bharat, Halasz, Annamaria, Hawari, Jalal   +2 more
openaire   +5 more sources