Results 11 to 20 of about 6,658 (162)
Toxicology Reports, 2017 Nitroreductase enzymes are responsible for the reduction of nitro functional groups to amino functional groups, and are found in a range of animal models, zebrafish (Danio rerio) excluded.
Anna C. Chlebowski +4 more
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Nitroreductase Activites in Giardia lamblia: ORF 17150 Encodes a Quinone Reductase with Nitroreductase Activity [PDF]
Pathogens, 2021 The intestinal diplomonadid Giardia lamblia is a causative agent of persistent diarrhea. Current treatments are based on nitro drugs, especially metronidazole. Nitro compounds are activated by reduction, yielding toxic intermediates.
Joachim Müller +4 more
doaj +3 more sources
ResearchCyanobacteria play pivotal roles in global biogeochemical cycles and aquatic ecosystems due to their widespread distribution and significant contributions to primary production.
Qiu-Lian Zhong, Jiu-Qiang Xiong
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Trigeminal and facial branchiomotor neurons have shared muscle targets in zebrafish larvae. [PDF]
J AnatCranial nerve innervation map, based on previous studies, shows the trigeminal and facial motor nerves confined to the mandibular and hyoid arch muscles, respectively, except for the trigeminal nerve in the interhyoideus muscle (M.IH). The revised cranial nerve innervation map, based on this study, shows the facial nerve in the intermandibularis ...
Ghosal R, McArthur KL, Eberhart JK.
europepmc +2 more sources
Topoisomerase-II mediated biochemical mapping of centromeres and nitroreductase mediated drug metabolism in Trypanosomatids [PDF]
, 2012 PhDThe protozoan parasites Trypanosoma cruzi and Trypanosoma brucei are the causative agents of Chagas disease and Human African sleeping sickness respectively.
Bot, Christopher
core +4 more sources
Trypanocidal Activity of Flavanone Derivatives
Molecules, 2020 Chagas disease, also known as American trypanosomiasis, is classified as a neglected disease by the World Health Organization. For clinical treatment, only two drugs have been on the market, Benznidazole and Nifurtimox, both of which are recommended for ...
Gabriela Maciel Diogo +5 more
doaj +1 more source
5-Nitrofuran-Tagged Oxazolyl Pyrazolopiperidines: Synthesis and Activity against ESKAPE Pathogens
Molecules, 2023 A series of eight 5-nitrofuran-tagged oxazolyl tetrahydropyrazolopyridines (THPPs) has been prepared in six stages with excellent regioselectivity.
Elizaveta Rogacheva +7 more
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Identification of Enterococcus faecalis enzymes with azoreductases and/or nitroreductase activity
BMC Microbiology, 2017 Background Nitroreductases, NAD(P)H dependent flavoenzymes, are found in most of bacterial species. Even if Enterococcus faecalis strains seems to present such activity because of their sensitivity to nitrofurans, no enzyme has been described ...
Valérie Chalansonnet +3 more
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Frontiers in Pharmacology, 2021 Bacterial nitroreductase enzymes that can efficiently convert nitroaromatic prodrugs to a cytotoxic form have numerous applications in targeted cellular ablation. For example, the generation of cytotoxic metabolites that have low bystander potential (i.e.
Abigail V. Sharrock +15 more
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Revista do Instituto de Medicina Tropical de São Paulo, 2013 Introduction Sporothrix schenckii is a thermal dimorphic pathogenic fungus causing a subcutaneous mycosis, sporotrichosis. Nitrocoumarin represents a fluorogenic substrate class where the microbial nitroreductase activity produces several derivatives ...
Cheila Denise Ottonelli Stopiglia +5 more
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