Results 21 to 30 of about 6,542 (200)
X-ray crystallographic studies of therapeutic enzymes: nitroreductase and AKR1C3 [PDF]
, 2003 The \(Escherichia\) \(coli\) enzyme nitroreductase has been proposed as a candidate for the Gene-Directed Enzyme Prodrug Therapy approach in treating cancer.
Lovering, Andrew
core +7 more sources
Topoisomerase-II mediated biochemical mapping of centromeres and nitroreductase mediated drug metabolism in Trypanosomatids [PDF]
, 2012 PhDThe protozoan parasites Trypanosoma cruzi and Trypanosoma brucei are the causative agents of Chagas disease and Human African sleeping sickness respectively.
Bot, Christopher
core +4 more sources
, 2001 Investigations were carried out to identify a suitable prodrug activating system for feline gene therapy with the eventual aim of treating feline thyroid disease and feline neoplasia. The E.
Reid, S.W.J. +3 more
core +8 more sources
Quinone- and nitroreductase reactions of Thermotoga maritima peroxiredoxin–nitroreductase hybrid enzyme [PDF]
Archives of Biochemistry and Biophysics, 2012 Thermotoga maritima peroxiredoxin-nitroreductase hybrid enzyme (Prx-NR) consists of a FMN-containing nitroreductase (NR) domain fused to a peroxiredoxin (Prx) domain. These domains seem to function independently as no electron transfer occurs between them.
Žilvinas, Anusevičius +5 more
openaire +2 more sources
Evolutionary aspects of the Viridiplantae nitroreductases [PDF]
Journal of Genetic Engineering and Biotechnology, 2020 Nitroreductases are a family of evolutionarily related proteins catalyzing the reduction of nitro-substituted compounds. Nitroreductases are widespread enzymes, but nearly all modern research and practical application have been concentrated on the bacterial proteins, mainly nitroreductases of Escherichia coli.
openaire +3 more sources
Frontiers in Pharmacology, 2021 Bacterial nitroreductase enzymes that can efficiently convert nitroaromatic prodrugs to a cytotoxic form have numerous applications in targeted cellular ablation. For example, the generation of cytotoxic metabolites that have low bystander potential (i.e.
Abigail V. Sharrock +15 more
doaj +1 more source
Revista do Instituto de Medicina Tropical de São Paulo, 2013 Introduction Sporothrix schenckii is a thermal dimorphic pathogenic fungus causing a subcutaneous mycosis, sporotrichosis. Nitrocoumarin represents a fluorogenic substrate class where the microbial nitroreductase activity produces several derivatives ...
Cheila Denise Ottonelli Stopiglia +5 more
doaj +1 more source
Fluorogenic substrates for the detection of microbial nitroreductases [PDF]
Letters in Applied Microbiology, 2001 To synthesize and evaluate fluorogenic substrates for the detection of microbial nitroreductases. These substrates, all based on 7-nitrocoumarin, may be reduced to form fluorescent aminocoumarins.Thirty pathogenic microbial strains, including both bacteria and yeasts, were examined for nitroreductase activity in a whole-cell assay.
James AL +5 more
openaire +3 more sources
Toxicology Reports, 2017 Nitroreductase enzymes are responsible for the reduction of nitro functional groups to amino functional groups, and are found in a range of animal models, zebrafish (Danio rerio) excluded.
Anna C. Chlebowski +4 more
doaj +1 more source
Nitro Reduction‐Based RNA Control and Ultrafast Release
Angewandte Chemie, EarlyView.A chemical RNA caging–uncaging strategy based on nitro reduction is described. Nitroaryl groups introduced via acylation temporarily block the functions of diverse RNAs in vitro and in living cells. Treatment with a diboronic acid–bipyridine mixture rapidly reduces the nitro groups, releasing RNAs and restoring their activity.
Yiran Zhao +6 more
wiley +2 more sources