Results 21 to 30 of about 6,658 (162)

E. coli nitroreductase/CB1954: In vitro studies into a potential system for feline cancer gene therapy

, 2001
Investigations were carried out to identify a suitable prodrug activating system for feline gene therapy with the eventual aim of treating feline thyroid disease and feline neoplasia. The E.
Reid, S.W.J., Blackwood, L., Argyle, D.J., O'Shaughnessy, P.J.   +3 more
core   +4 more sources

Novel Lysosome-Targeting Fluorescence Off-On Photosensitizer for Near-Infrared Hypoxia Imaging and Photodynamic Therapy In Vitro and In Vivo

Molecules, 2022
Photodynamic therapy (PDT) has emerged as a new antitumor modality. Hypoxia, a vital characteristic of solid tumors, can be explored to stimulate the fluorescence response of photosensitizers (PSs).
Shangli Ding, Mingyan Yang, Jiajia Lv, Hongyu Li, Gang Wei, Jie Gao, Zeli Yuan   +6 more
doaj   +1 more source

Detection of Microbial Nitroreductase Activity by Monitoring Exogenous Volatile Organic Compound Production Using HS-SPME-GC-MS

Separations, 2020
Development of a rapid approach for universal microbial detection is required in the healthcare, food and environmental sectors to aid with medical intervention, food safety and environmental protection.
Ryan Thompson, John D. Perry, Stephen P. Stanforth, John R. Dean   +3 more
doaj   +1 more source

Engineering an asymmetric rhodamine dye suitable for developing ratiometric fluorescent probe

Smart Molecules, 2023
Fluorescent probes based on rhodamine skeleton are extensively used in biological imaging. However, the construction of ratiometric fluorescent probes based on the rhodamine skeleton without introducing additional fluorophores is still challenging ...
Feiyu Yang, Peng Lu, Tian‐Bing Ren, Xiao‐Bing Zhang, Lin Yuan   +4 more
doaj   +1 more source

Strategies of Detecting Bacteria Using Fluorescence-Based Dyes

Frontiers in Chemistry, 2021
Identification of bacterial strains is critical for the theranostics of bacterial infections and the development of antibiotics. Many organic fluorescent probes have been developed to overcome the limitations of conventional detection methods.
Shin A Yoon, Sun Young Park, Yujin Cha, Lavanya Gopala, Min Hee Lee   +4 more
doaj   +1 more source

NTO Degradation by Nitroreductase: A DFT Study

, 2022
NTO (5-nitro-1,2,4-triazol-3-one), an energetic material used in military applications, may be released to the environment during manufacturing, transportation, storage, training, and disposal.
Leonid Gorb (1514851), Jerzy Leszczynski (1371450), Liudmyla K. Sviatenko (1562848)   +2 more
core   +1 more source

Nitro Reduction‐Based RNA Control and Ultrafast Release

Angewandte Chemie, Volume 138, Issue 40, 28 September 2026.
A chemical RNA caging–uncaging strategy based on nitro reduction is described. Nitroaryl groups introduced via acylation temporarily block the functions of diverse RNAs in vitro and in living cells. Treatment with a diboronic acid–bipyridine mixture rapidly reduces the nitro groups, releasing RNAs and restoring their activity.
Yiran Zhao, Senfeng Zhang, Junsong Guo, Tuan‐Khoa Kha, Song Chen, Chunyi Hu, Ru‐Yi Zhu   +6 more
wiley   +2 more sources

Recent advances and applications of nitroreductase activable agents for tumor theranostic

Frontiers in Pharmacology
Nitroreductase activable agents offer a personalized and targeted approach to cancer theranostics by selectively activating prodrugs within the tumor microenvironment.
Baoxin Shang, Zongjiang Yu, Zongjiang Yu, Zongjiang Yu, Zhengdan Wang   +4 more
doaj   +1 more source

Hypoxia-Inducible Regulation of a Prodrug-Activating Enzyme for Tumor-Specific Gene Therapy

Neoplasia: An International Journal for Oncology Research, 2002
Previous studies have suggested that tumor hypoxia could be exploited for cancer gene therapy. Using hypoxia-responsive elements derived from the human vascular endothelial growth factor gene, we have generated vectors expressing a bacterial ...
Toru Shibata, Amato J. Giaccia, J. Martin Brown   +2 more
doaj   +1 more source

Megazol and its bioisostere 4H-1,2,4-triazole: comparing the trypanocidal, cytotoxic and genotoxic activities and their in vitro and in silico interactions with the Trypanosoma brucei nitroreductase enzyme

Memorias do Instituto Oswaldo Cruz, 2014
Megazol (7) is a 5-nitroimidazole that is highly active against Trypanosoma cruzi and Trypanosoma brucei, as well as drug-resistant forms of trypanosomiasis.
Alcione Silva de Carvalho, Kelly Salomão, Solange Lisboa de Castro, Taline Ramos Conde, Helena Pereira da Silva Zamith, Ernesto Raúl Caffarena, Belinda Suzette Hall, Shane Robert Wilkinson, Núbia Boechat   +8 more
doaj   +1 more source