Results 21 to 30 of about 5,837 (209)

A coelenterazine-type bioluminescent probe for nitroreductase imaging

Organic & Biomolecular Chemistry, 2018
Novel coelenterazine-type bioluminescent probes have been designed and synthesized to detect nitroreductase (NTR) in hypoxic tumors.
Xingye Yang, Zhenzhen Li, Tianyu Jiang, Lupei Du, Minyong Li   +4 more
openaire   +3 more sources

Informing Efforts to Develop Nitroreductase for Amine Production [PDF]

Molecules, 2018
Nitroreductases (NRs) hold promise for converting nitroaromatics to aromatic amines. Nitroaromatic reduction rate increases with Hammett substituent constant for NRs from two different subgroups, confirming substrate identity as a key determinant of ...
Anne-Frances Miller, Jonathan T. Park, Kyle L. Ferguson, Warintra Pitsawong, Andreas S. Bommarius   +4 more
doaj   +3 more sources

The Role of Nitroreductases in Resistance to Nitroimidazoles [PDF]

Biology, 2021
Antimicrobial resistance is a major challenge facing modern medicine, with an estimated 700,000 people dying annually and a global cost in excess of $100 trillion. This has led to an increased need to develop new, effective treatments. This review focuses on nitroimidazoles, which have seen a resurgence in interest due to their broad spectrum of ...
Carol Thomas, Christopher D. Gwenin
openaire   +3 more sources

Anti-Trypanosoma cruzi Activity, Mutagenicity, Hepatocytotoxicity and Nitroreductase Enzyme Evaluation of 3-Nitrotriazole, 2-Nitroimidazole and Triazole Derivatives

Molecules, 2023
Chagas disease (CD), which is caused by Trypanosoma cruzi and was discovered more than 100 years ago, remains the leading cause of death from parasitic diseases in the Americas.
Cheyene Almeida Celestino Menozzi, Rodolfo Rodrigo Florido França, Pedro Henrique Luccas, Mayara dos Santos Baptista, Tácio Vinício Amorim Fernandes, Lucas Villas Bôas Hoelz, Policarpo Ademar Sales Junior, Silvane Maria Fonseca Murta, Alvaro Romanha, Bárbara Verena Dias Galvão, Marcela de Oliveira Macedo, Alana da Cunha Goldstein, Carlos Fernando Araujo-Lima, Israel Felzenszwalb, Maria Cristina Nonato, Frederico Silva Castelo-Branco, Nubia Boechat   +16 more
doaj   +1 more source

Effect of Reduced Tillage on Soil Enzyme Activity, Pests Pressure and Productivity of Organically Grown Spring Wheat Species

Agronomy, 2023
The possibility of using reduced tillage in organic farming is poorly recognized. The study aimed to assess the impact of the tillage method (shallow tillage and plowing) on soil biochemical activity, pest pressure, and grain yield of Triticum ...
Małgorzata Szczepanek, Anetta Siwik-Ziomek, Grzegorz Lemańczyk, Robert Lamparski, Radomir Graczyk   +4 more
doaj   +1 more source

RETRACTED: An acridone-derived fluorescent off-on probe for detection and in vivo imaging of nitroreductase

Frontiers in Materials, 2023
Understanding the functions of enzymes in various physiological processes is important, but the design of signaling probes for fast analysis of enzymatic activity is particularly challenging.
Meicen Liu, Guanyu Chen, Guanyu Chen, Lilan Xu, Lilan Xu, Tingting Chen, Tingting Chen, Wenqian Chen, Wenqian Chen, Jinghua Chen, Jinghua Chen, Xi Zhang   +11 more
doaj   +1 more source

CpxA/R‐Controlled Nitroreductase Expression as Target for Combinatorial Therapy against Uropathogens by Promoting Reactive Oxygen Species Generation

Advanced Science, 2023
The antibiotic resistances emerged in uropathogens lead to accumulative treatment failure and recurrent episodes of urinary tract infection (UTI), necessitating more innovative therapeutics to curb UTI before systematic infection.
Hao Ren, Zixing Zhong, Shuang Zhou, Yiyang Wei, Yujiao Liang, Huiling He, Zijian Zheng, Mengyuan Li, Qian He, Tengfei Long, Xinlei Lian, Xiaoping Liao, Yahong Liu, Jian Sun   +13 more
doaj   +1 more source

Evolutionary aspects of the Viridiplantae nitroreductases [PDF]

Journal of Genetic Engineering and Biotechnology, 2020
Nitroreductases are a family of evolutionarily related proteins catalyzing the reduction of nitro-substituted compounds. Nitroreductases are widespread enzymes, but nearly all modern research and practical application have been concentrated on the bacterial proteins, mainly nitroreductases of Escherichia coli.
openaire   +3 more sources

Fluorogenic substrates for the detection of microbial nitroreductases [PDF]

Letters in Applied Microbiology, 2001
To synthesize and evaluate fluorogenic substrates for the detection of microbial nitroreductases. These substrates, all based on 7-nitrocoumarin, may be reduced to form fluorescent aminocoumarins.Thirty pathogenic microbial strains, including both bacteria and yeasts, were examined for nitroreductase activity in a whole-cell assay.
James AL, Perry JD, Jay C, Monget D, Rasburn JW, Gould FK   +5 more
openaire   +3 more sources

Use of nfsB, encoding nitroreductase, as a reporter gene to determine the mutational spectrum of spontaneous mutations in Neisseria gonorrhoeae

BMC Microbiology, 2009
Background Organisms that are sensitive to nitrofurantoin express a nitroreductase. Since bacterial resistance to this compound results primarily from mutations in the gene encoding nitroreductase, the resulting loss of function of nitroreductase results
Dunham Stephen, Carrizosa Esteban, Stein Daniel C   +2 more
doaj   +1 more source