Results 31 to 40 of about 6,658 (162)
mBio, 2020 One avenue to combat multidrug-resistant Gram-negative bacteria is the coadministration of multiple drugs (combination therapy), which can be particularly promising if drugs synergize.
Janine N. Copp +11 more
doaj +1 more source
Hyperpolarization of Pyridine 15N‐Oxide Molecular Probes Enabled by Parahydrogen
Angewandte Chemie, Volume 138, Issue 37, 7 September 2026.Pyridine 15N‐oxides are introduced as motifs for hyperpolarization studies and biochemical applications are demonstrated. ABSTRACT Magnetic resonance (MR) is a powerful non‐invasive technique for probing structural, functional, and metabolic processes with high spatial and temporal resolution.
Ruhuai Mei +8 more
wiley +2 more sources
An activatable biphotonic lanthanide probe for detection of nitroreductase in live bacteria and cancer cells [PDF]
imaging. The terbium-based luminescent probe is non-fluorescent in its inactive state but can be selectively activated by nitroreductase, leading to the release of the sensitizing antenna that facilitates energy transfer to the lanthanide center ...
Qian, Liu +5 more
core +2 more sources
A “Double-Locked” and Enzyme/pH-Activated Theranostic Agent for Accurate Tumor Imaging and Therapy
Molecules, 2022 Theranostic agents for concurrent cancer therapy and diagnosis have begun attracting attention as a promising modality. However, accurate imaging and identification remains a great challenge for theranostic agents.
Jia Luo +9 more
doaj +1 more source
Acid‐Stable Nitrofuran Triple Therapy With Rabeprazole and Amoxicillin Targeting Helicobacter pylori Infection [PDF]
MedComm (2020)Overview: Novel nitrofuran derivatives were developed and evaluated against Helicobacter pylori to overcome antibiotic resistance and inflammation. Methods and Findings: In vitro assays using H. pylori 60190 and PMSS1 strains demonstrated potent antibacterial activity, reduced bacterial adhesion, and inhibited cytokine release from gastric epithelial ...
Tharmalingam N +7 more
europepmc +2 more sources
Advanced Science, EarlyView.Tools for controlled selenol delivery are crucial for exploring Se‐related biology and medicine, but compound platforms for triggerable release of CH3SeH remain lacking. Herein, we report the first general triggered platform (TD‐MSe) for efficient cyclization release of CH3SeH in live cells.
Wenfang Liang +7 more
wiley +1 more source
, 2018 A dual functional ratiometric fluorescent probe can obviously distinguish acidity, nitroreductase, and nitroreductase in an acidic environment.
Yajie Chou +5 more
core +1 more source
Frontiers in Catalysis, 2022 Hydrogenase-mediated reduction of flavin mononucleotide by H2 is exploited to enable cleaner application of nitroreductase enzymes for reduction of aromatic nitro functional groups. This turns the overall reaction into a biocatalytic hydrogenation.
Miguel A. Ramirez +5 more
doaj +1 more source
Mass Spectrometry Reviews, EarlyView.ABSTRACT Nitrooxidative stress, driven by excess reactive nitrogen species like peroxynitrite, contributes to the pathogenesis of many chronic diseases. Among its molecular footprints, 3‐nitrotyrosine (3NT) has emerged as a biologically relevant marker of protein nitration.
Brîndușa Alina Petre
wiley +1 more source
Accessing active fragments for drug discovery utilising nitroreductase biocatalysis [PDF]
Biocatalysis has played a limited role in the early stages of drug discovery. This is often attributed to the limited substrate scope of enzymes not affording access to vast areas of novel chemical space.
Eda, Yuce +6 more
core +1 more source