Results 31 to 40 of about 5,837 (209)

Trypanocidal Activity of Flavanone Derivatives

Molecules, 2020
Chagas disease, also known as American trypanosomiasis, is classified as a neglected disease by the World Health Organization. For clinical treatment, only two drugs have been on the market, Benznidazole and Nifurtimox, both of which are recommended for ...
Gabriela Maciel Diogo, Josimara Souza Andrade, Policarpo Ademar Sales Junior, Silvane Maria Fonseca Murta, Viviane Martins Rebello Dos Santos, Jason Guy Taylor   +5 more
doaj   +1 more source

A Novel NIR Fluorescent Probe for Highly Selective Detection of Nitroreductase and Hypoxic-Tumor-Cell Imaging

Molecules, 2021
Nitroreductase as a potential biomarker for aggressive tumors has received extensive attention. In this work, a novel NIR fluorescent probe for nitroreductase detection was synthesized.
Feng Liu, Hong Zhang, Kun Li, Yongmei Xie, Zhihui Li   +4 more
doaj   +1 more source

5-Nitrofuran-Tagged Oxazolyl Pyrazolopiperidines: Synthesis and Activity against ESKAPE Pathogens

Molecules, 2023
A series of eight 5-nitrofuran-tagged oxazolyl tetrahydropyrazolopyridines (THPPs) has been prepared in six stages with excellent regioselectivity.
Elizaveta Rogacheva, Lyudmila Kraeva, Alexey Lukin, Lyubov Vinogradova, Kristina Komarova, Mikhail Chudinov, Maxim Gureev, Evgeny Chupakhin   +7 more
doaj   +1 more source

APPLICATION OF 6-NITROCOUMARIN AS A SUBSTRATE FOR THE FLUORESCENT DETECTION OF NITROREDUCTASE ACTIVITY IN Sporothrix schenckii

Revista do Instituto de Medicina Tropical de São Paulo, 2013
Introduction Sporothrix schenckii is a thermal dimorphic pathogenic fungus causing a subcutaneous mycosis, sporotrichosis. Nitrocoumarin represents a fluorogenic substrate class where the microbial nitroreductase activity produces several derivatives ...
Cheila Denise Ottonelli Stopiglia, Mariana Carissimi, Tatiane Caroline Daboit, Valter Stefani, Valeriano Antonio Corbellini, Maria Lucia Scroferneker   +5 more
doaj   +1 more source

Reduction of polynitroaromatic compounds: the bacterial nitroreductases [PDF]

FEMS Microbiology Reviews, 2008
Most nitroaromatic compounds are toxic and mutagenic for living organisms, but some microorganisms have developed oxidative or reductive pathways to degrade or transform these compounds. Reductive pathways are based either on the reduction of the aromatic ring by hydride additions or on the reduction of the nitro groups to hydroxylamino and/or amino ...
María Dolores, Roldán, Eva, Pérez-Reinado, Francisco, Castillo, Conrado, Moreno-Vivián   +3 more
openaire   +2 more sources

A “Double-Locked” and Enzyme/pH-Activated Theranostic Agent for Accurate Tumor Imaging and Therapy

Molecules, 2022
Theranostic agents for concurrent cancer therapy and diagnosis have begun attracting attention as a promising modality. However, accurate imaging and identification remains a great challenge for theranostic agents.
Jia Luo, Zongyu Guan, Weijie Gao, Chen Wang, Zhongyuan Xu, Chi Meng, Yun Liu, Yuquan Zhang, Qingsong Guo, Yong Ling   +9 more
doaj   +1 more source

Detection of Microbial Nitroreductase Activity by Monitoring Exogenous Volatile Organic Compound Production Using HS-SPME-GC-MS

Separations, 2020
Development of a rapid approach for universal microbial detection is required in the healthcare, food and environmental sectors to aid with medical intervention, food safety and environmental protection.
Ryan Thompson, John D. Perry, Stephen P. Stanforth, John R. Dean   +3 more
doaj   +1 more source

H2-Driven Reduction of Flavin by Hydrogenase Enables Cleaner Operation of Nitroreductases for Nitro-Group to Amine Reductions

Frontiers in Catalysis, 2022
Hydrogenase-mediated reduction of flavin mononucleotide by H2 is exploited to enable cleaner application of nitroreductase enzymes for reduction of aromatic nitro functional groups. This turns the overall reaction into a biocatalytic hydrogenation.
Miguel A. Ramirez, Shiny Joseph Srinivasan, Sarah E. Cleary, Peter M. T. Todd, Holly A. Reeve, Kylie A. Vincent   +5 more
doaj   +1 more source

Ratiometric Fluorescence Assay for Nitroreductase Activity: Locked-Flavylium Fluorophore as a NTR-Sensitive Molecular Probe

Molecules, 2021
Nitroreductases belong to a member of flavin-containing enzymes that can reduce nitroaromatic compounds to amino derivatives with NADH as an electron donor.
Su Jung Kim, Jung Won Yoon, Shin A Yoon, Min Hee Lee   +3 more
doaj   +1 more source

Identification of a type I nitroreductase gene in non-virulent Trypanosoma rangeli [PDF]

, 2017
Trypanosomatid type I nitroreductases (NTRs), i.e., mitochondrial enzymes that metabolise nitroaromatic pro-drugs, are essential for parasite growth, infection, and survival.
Claudia Cuervo, Jenny R Díaz, Constanza Cardenas, Díaz, Jenny R, Concepcion J Puerta, Puerta, Concepción J., Duarte, Silvia, Cuervo, Claudia, Montenegro, Marjorie, M Carmen Thomas, Manuel C Lopez, Marjorie Montenegro, López López, Manuel Carlos, Cárdenas, Constanza, Silvia Duarte, Thomas, María del Carmen   +15 more
core   +1 more source