Results 31 to 40 of about 6,542 (200)
Accessing active fragments for drug discovery utilising nitroreductase biocatalysis [PDF]
Biocatalysis has played a limited role in the early stages of drug discovery. This is often attributed to the limited substrate scope of enzymes not affording access to vast areas of novel chemical space.
Eda, Yuce +6 more
core +2 more sources
A “Double-Locked” and Enzyme/pH-Activated Theranostic Agent for Accurate Tumor Imaging and Therapy
Molecules, 2022 Theranostic agents for concurrent cancer therapy and diagnosis have begun attracting attention as a promising modality. However, accurate imaging and identification remains a great challenge for theranostic agents.
Jia Luo +9 more
doaj +1 more source
Separations, 2020 Development of a rapid approach for universal microbial detection is required in the healthcare, food and environmental sectors to aid with medical intervention, food safety and environmental protection.
Ryan Thompson +3 more
doaj +1 more source
Frontiers in Catalysis, 2022 Hydrogenase-mediated reduction of flavin mononucleotide by H2 is exploited to enable cleaner application of nitroreductase enzymes for reduction of aromatic nitro functional groups. This turns the overall reaction into a biocatalytic hydrogenation.
Miguel A. Ramirez +5 more
doaj +1 more source
Reduction of polynitroaromatic compounds: the bacterial nitroreductases [PDF]
FEMS Microbiology Reviews, 2008 Most nitroaromatic compounds are toxic and mutagenic for living organisms, but some microorganisms have developed oxidative or reductive pathways to degrade or transform these compounds. Reductive pathways are based either on the reduction of the aromatic ring by hydride additions or on the reduction of the nitro groups to hydroxylamino and/or amino ...
María Dolores, Roldán +3 more
openaire +2 more sources
Molecules, 2021 Nitroreductases belong to a member of flavin-containing enzymes that can reduce nitroaromatic compounds to amino derivatives with NADH as an electron donor.
Su Jung Kim +3 more
doaj +1 more source
Hyperpolarization of Pyridine 15N‐Oxide Molecular Probes Enabled by Parahydrogen
Angewandte Chemie, Volume 138, Issue 37, 7 September 2026.Pyridine 15N‐oxides are introduced as motifs for hyperpolarization studies and biochemical applications are demonstrated. ABSTRACT Magnetic resonance (MR) is a powerful non‐invasive technique for probing structural, functional, and metabolic processes with high spatial and temporal resolution.
Ruhuai Mei +8 more
wiley +2 more sources
Cell-Specific Chemical Delivery Using a Selective Nitroreductase–Nitroaryl Pair [PDF]
, 2018 The utility of small molecules to probe or perturb biological systems is limited by the lack of cell-specificity. ‘Masking’ the activity of small molecules using a general chemical modification and ‘unmasking’ it only within target cells could overcome ...
Michael R., Tadross +6 more
core +2 more sources
Recent advances and applications of nitroreductase activable agents for tumor theranostic
Frontiers in PharmacologyNitroreductase activable agents offer a personalized and targeted approach to cancer theranostics by selectively activating prodrugs within the tumor microenvironment.
Baoxin Shang +4 more
doaj +1 more source
Molecules, 2022 Photodynamic therapy (PDT) has emerged as a new antitumor modality. Hypoxia, a vital characteristic of solid tumors, can be explored to stimulate the fluorescence response of photosensitizers (PSs).
Shangli Ding +6 more
doaj +1 more source