Results 41 to 50 of about 6,542 (200)
eLife, 2020 Selection for a promiscuous enzyme activity provides substantial opportunity for competition between endogenous and newly-encountered substrates to influence the evolutionary trajectory, an aspect that is often overlooked in laboratory directed evolution
Kelsi R Hall +10 more
doaj +1 more source
Hypoxia-Inducible Regulation of a Prodrug-Activating Enzyme for Tumor-Specific Gene Therapy
Neoplasia: An International Journal for Oncology Research, 2002 Previous studies have suggested that tumor hypoxia could be exploited for cancer gene therapy. Using hypoxia-responsive elements derived from the human vascular endothelial growth factor gene, we have generated vectors expressing a bacterial ...
Toru Shibata +2 more
doaj +1 more source
Environmental Identification of Novel Enzymes for Polyurethane and Polyamide Degradation
Angewandte Chemie, Volume 138, Issue 35, 24 August 2026.Heteroatom‐containing plastics such as polyurethanes and nylons are produced at scale yet remain largely unrecycled. Biocatalysts offer a promising route to depolymerization under mild conditions. Here, we present a screening platform for the discovery of novel polyurethane‐ and nylon‐degrading enzymes from environmental samples and demonstrate ...
Malthe Kjær Bendtsen +17 more
wiley +2 more sources
Memorias do Instituto Oswaldo Cruz, 2014 Megazol (7) is a 5-nitroimidazole that is highly active against Trypanosoma cruzi and Trypanosoma brucei, as well as drug-resistant forms of trypanosomiasis.
Alcione Silva de Carvalho +8 more
doaj +1 more source
Engineering an asymmetric rhodamine dye suitable for developing ratiometric fluorescent probe
Smart Molecules, 2023 Fluorescent probes based on rhodamine skeleton are extensively used in biological imaging. However, the construction of ratiometric fluorescent probes based on the rhodamine skeleton without introducing additional fluorophores is still challenging ...
Feiyu Yang +4 more
doaj +1 more source
An activatable biphotonic lanthanide probe for detection of nitroreductase in live bacteria and cancer cells [PDF]
imaging. The terbium-based luminescent probe is non-fluorescent in its inactive state but can be selectively activated by nitroreductase, leading to the release of the sensitizing antenna that facilitates energy transfer to the lanthanide center ...
Qian, Liu +5 more
core +2 more sources
Strategies of Detecting Bacteria Using Fluorescence-Based Dyes
Frontiers in Chemistry, 2021 Identification of bacterial strains is critical for the theranostics of bacterial infections and the development of antibiotics. Many organic fluorescent probes have been developed to overcome the limitations of conventional detection methods.
Shin A Yoon +4 more
doaj +1 more source
BMEMat, EarlyView.Nanomaterials revolutionize ocular infection treatment by enabling targeted drug delivery and enhanced antimicrobial efficacy against resistant pathogens. This review systematically explores their rational design, multimodal mechanisms, and translational potential for next‐generation anti‐infective therapies.
Yujia Liu +7 more
wiley +1 more source
Nitroreductase activity of heart lipoamide dehydrogenase [PDF]
Biochemical Journal, 1987 A novel reaction catalysed by lipoamide dehydrogenase is described. In the presence of NADH, lipoamide dehydrogenase reduces the nitro group of 4-nitropyridine and 4-nitropyridine N-oxide. The elution profiles from a DEAE-cellulose column for the dehydrogenase and nitroreductase activities are identical.
openaire +2 more sources
, 2019 Lysine-specific demethylase 1 (LSD1) has evolved as a promising therapeutic target for cancer treatment, especially in acute myeloid leukaemia (AML). To approach the challenge of site-specific LSD1 inhibition, we developed an enzyme-prodrug system with ...
Simon Steimle (7525388) +10 more
core +1 more source