Results 61 to 70 of about 6,658 (162)

Asymmetric and Reduced Xanthene Fluorophores: Synthesis, Photochemical Properties, and Application to Activatable Fluorescent Probes for Detection of Nitroreductase

Molecules, 2019
Xanthene fluorophores, including fluorescein, rhodol, and rhodamines, are representative classes of fluorescent probes that have been applied in the detection and visualization of biomolecules.
Kunal N. More, Tae-Hwan Lim, Julie Kang, Hwayoung Yun, Sung-Tae Yee, Dong-Jo Chang   +5 more
doaj   +1 more source

The Pineal Gland Is Required for Optimal Nighttime Immunity to Bacterial Infection in Larval Zebrafish

Journal of Pineal Research, Volume 78, Issue 5, September 2026.
ABSTRACT The immune response to bacterial infection demonstrates circadian rhythmicity, with heightened antibacterial immunity often observed during the daytime. This circadian‐gated immune response is believed to have evolved to synchronize peak antibacterial immunity with the increased threat of infection when active.
Gabriel Anasarias‐Dumo, Yevetta Y. Xiang, David Cumin, James F. Cheeseman, Guy R. Warman, Jonathan W. Astin, Christopher J. Hall   +6 more
wiley   +1 more source

Phytodetoxification of TNT by transgenic plants expressing bacterial nitroreductase

, 2001
There is major international concern over the wide-scale contamination of soil and associated ground water by persistent explosives residues. 2,4,6-Trinitrotoluene (TNT) is one of the most recalcitrant and toxic of all the military explosives.
French, CE, Susan J. Rosser, Neil C. Bruce, Nerissa Hannink, Bruce, NC, Stephen Nicklin, Hannink, N., Nicklin, S., Rosser, SJ, Bruce, N.C., Murray, JAH, Amrik Basran, Murray, J.A.H., Christopher E. French, Basran, A, Nicklin, S, James A.H. Murray, Rosser, S.J., French, C.E., Hannink, N, Basran, A.   +20 more
core   +1 more source

Bystander or No Bystander for Gene Directed Enzyme Prodrug Therapy

Molecules, 2009
Gene directed enzyme prodrug therapy (GDEPT) of cancer aims to improve the selectivity of chemotherapy by gene transfer, thus enabling target cells to convert nontoxic prodrugs to cytotoxic drugs.
Adam V. Patterson, Dean C. Singleton, Sophie Syddall, Michelle A. Hunt, Gabi U. Dachs   +4 more
doaj   +1 more source

Activation of 1-nitropyrene by nitroreductase increases the DNA adduct level and mutagenicity [PDF]

, 1998
1-Nitropyrene (1-NP) is a mutagenic nitro compound in the environment. We studied correlations between the mutagenicity of 1-NP for three strains of Salmonella typhimurium, the activity of bacterial nitroreductases and the amount of 1-NP-derived DNA ...
Ohnishi, Yoshinari, キノウチ, タケミ, 有持, 秀喜, カタオカ, ケイコ, 片岡, 佳子, 60214/profile-ja.html, 桑原, 知巳, Arimochi, Hideki, Kuwahara, Tomomi, 30311822, Kataoka, Keiko, 40189303, 1596, 60167/profile-ja.html, 60212/profile-ja.html, クワハラ, トモミ, アリモチ, ヒデキ, オオニシ, ヨシナリ, 1617, 1616, 大西, 克成, Kinouchi, Takemi   +21 more
core  

Gut microbial metabolism of Flutamide attenuates its therapeutic efficacy against prostate cancer

Gut Microbes
Endocrine drugs serve as the cornerstone of prostate cancer treatment. Flutamide, a representative first-generation antiandrogen, has been relegated to the treatment of recurrent prostate cancer due to novel drug development and therapeutic resistance ...
Shujing Li, Haiying Ding, Jiaqi Wang, Lingjie Yuan, Ying Zhou, Weiben Xu, Hang Yin, Mengqian Ye, Yuning Sha, Fangyin Li, Yousheng Liu, Zhengqin Zhu, Lulu Song, Xiangyu Jin, Liefeng Ma, Zhajun Zhan, Libin Pan, Luo Fang   +17 more
doaj   +1 more source

Unraveling Mechanisms and Epidemic Characteristics of Nitrofurantoin Resistance in Uropathogenic Enterococcus faecium Clinical Isolates

Infection and Drug Resistance, 2021
Ying Zhang,1 Lingbo Wang,2 Cui Zhou,2 Yishuai Lin,1 Shixing Liu,2 Weiliang Zeng,1 Kaihang Yu,1 Tieli Zhou,2 Jianming Cao1 1Department of Medical Lab Science, School of Laboratory Medicine and Life Science, Wenzhou Medical University, Wenzhou, Zhejiang ...
Zhang Y, Wang L, Zhou C, Lin Y, Liu S, Zeng W, Yu K, Zhou T, Cao J   +8 more
doaj  

Cell-Penetrating Peptides as a Tool for the Cellular Uptake of a Genetically Modified Nitroreductase for use in Directed Enzyme Prodrug Therapy

Journal of Functional Biomaterials, 2019
Directed enzyme prodrug therapy (DEPT) involves the delivery of a prodrug-activating enzyme to a solid tumour site, followed by the subsequent activation of an administered prodrug.
Simon D. Anderson, Robert J. Hobbs, Vanessa V. Gwenin, Patrick Ball, Lindsey A. Bennie, Jonathan A. Coulter, Chris D. Gwenin   +6 more
doaj   +1 more source

Therapeutic Applications of Stimuli‐Based Release and Engineering of Extracellular Vesicles

Advanced NanoBiomed Research, Volume 6, Issue 8, August 2026.
This review summarizes the effects of endogenous and exogenous stimuli, their effects on the natural release of extracellular vesicles, as well as their uptake and release. It also gives an overview of stimuli‐responsive EVs and their therapeutic applications. Extracellular vesicles (EVs), nano‐ to microsized lipid bilayer membrane‐bound particles, are
Gloria Kemunto, Kristen Dellinger
wiley   +1 more source

NITROREDUCTASE NfnB FROM Mycobacterium smegmatis

, 2008
The present invention relates to a screening method for the identification of new nitrobenzothiazinone drugs for the treatment of tuberculosis, which are not or are slowly transformed and inactivated by nitroreductase.
PASCA, MARIA ROSALIA, MANINA, GIULIA, RICCARDI, GIOVANNA   +2 more
core