Results 61 to 70 of about 6,542 (200)

Identification of a type I nitroreductase gene in non-virulent Trypanosoma rangeli [PDF]

, 2017
Trypanosomatid type I nitroreductases (NTRs), i.e., mitochondrial enzymes that metabolise nitroaromatic pro-drugs, are essential for parasite growth, infection, and survival.
Claudia Cuervo, Jenny R Díaz, Constanza Cardenas, Díaz, Jenny R, Concepcion J Puerta, Puerta, Concepción J., Duarte, Silvia, Cuervo, Claudia, Montenegro, Marjorie, M Carmen Thomas, Manuel C Lopez, Marjorie Montenegro, López López, Manuel Carlos, Cárdenas, Constanza, Silvia Duarte, Thomas, María del Carmen   +15 more
core   +1 more source

CYP1A1 and Cnr nitroreductase bioactivated niclosamide in vitro [PDF]

Mutagenesis, 2013
Abstract Niclosamide produces genotoxic effects, such as point mutations in Salmonella sp., sperm-head abnormalities in mice and clastogenic effects in human lymphocytes in vitro and in vivo. As cytochrome P450 could be involved in the bioactivation of niclosamide, we investigated which subfamily was involved.
Evelyn, Beristain-Castillo, Mariano, Martínez-Vázquez, Rafael, Camacho-Carranza, Javier J, Espinosa-Aguirre   +3 more
openaire   +2 more sources

Molecular Periphery Design Allows Control of the New Nitrofurans Antimicrobial Selectivity

Molecules
A series of 13 new 3-substituted 5-(5-nitro-2-furyl)-1,2,4-oxadiazoles was synthesized from different aminonitriles. All compounds were screened in the disc diffusion test at a 100 μg/mL concentration to determine the bacterial growth inhibition zone ...
Lyubov Vinogradova, Alexey Lukin, Kristina Komarova, Maxim Zhuravlev, Artem Fadeev, Mikhail Chudinov, Elizaveta Rogacheva, Lyudmila Kraeva, Maxim Gureev, Yuri Porozov, Marine Dogonadze, Tatiana Vinogradova   +11 more
doaj   +1 more source

Therapeutic Applications of Stimuli‐Based Release and Engineering of Extracellular Vesicles

Advanced NanoBiomed Research, Volume 6, Issue 8, August 2026.
This review summarizes the effects of endogenous and exogenous stimuli, their effects on the natural release of extracellular vesicles, as well as their uptake and release. It also gives an overview of stimuli‐responsive EVs and their therapeutic applications. Extracellular vesicles (EVs), nano‐ to microsized lipid bilayer membrane‐bound particles, are
Gloria Kemunto, Kristen Dellinger
wiley   +1 more source

Comparison of the azoreductase and nitroreductase from Clostridium perfringens [PDF]

Applied and Environmental Microbiology, 1993
The purified azoreductase and nitroreductase of Clostridium perfringens, which have similar electrophoretic properties, both reacted in a Western blot (immunoblot) with a polyclonal antibody raised against the azoreductase. The activity of both enzymes was enhanced by flavin adenine dinucleotide and was inhibited by menadione, o-iodosobenzoic acid, and
F, Rafii, C E, Cerniglia
openaire   +2 more sources

The X‐Ray Crystal Structure of BorF, the Flavin Reductase Subunit of a Two‐Component Flavin‐Dependent Tryptophan Halogenase

Proteins: Structure, Function, and Bioinformatics, Volume 94, Issue 8, Page 1529-1540, August 2026.
ABSTRACT BorF is a short‐chain flavin reductase from a desert soil bacterium that uses NADH to reduce FAD to FADH2, which is used by the tryptophan‐6‐halogenase BorH to chlorinate tryptophan in the biosynthetic pathway of borregomycin A. The X‐ray crystal structure of BorF bound to FAD was solved to 2.37 Å by molecular replacement.
Zheng Ma, Emily W. Rady, Aravinda J. de Silva, John J. Bellizzi III   +3 more
wiley   +1 more source

Responsive nitric oxide‐releasing antibacterial materials for biofilm‐associated infections: Mechanisms, design strategies, and applications

Responsive Materials, Volume 4, Issue 3, August 2026.
This review summarizes the recent progress in responsive NO‐releasing materials and their applications in biofilm‐associated infectious diseases. The design principles and response mechanisms are given to provide inspiration toward the future development of multi‐responsive NO‐releasing materials.
Wenyue Sun, Meiqi Li, Di Nan, Jiaqi Zhao, Yu Chen, Yao Gao, Shichen Zhang, Kirsten L. Van Landuyt, Manlin Qi   +8 more
wiley   +1 more source

Peptide‐based responsive molecular fluorescent probes for precision oncology

Responsive Materials, Volume 4, Issue 3, August 2026.
Peptide‐based responsive fluorescent probes have emerged as adaptive functional materials for precision tumor theranostics, combining tumor‐selective recognition, programmable stimulus responsiveness, and modular tunability. They enable high‐contrast imaging, intraoperative guidance, real‐time monitoring, and multimodal applications, while next ...
Xing Wang, Wen Liu, Jiahao Zhang, Wanqi Wang, Zhicheng Jin, Yuqi Tang, Quan Li   +6 more
wiley   +1 more source

Phytodetoxification of TNT by transgenic plants expressing bacterial nitroreductase

, 2001
There is major international concern over the wide-scale contamination of soil and associated ground water by persistent explosives residues. 2,4,6-Trinitrotoluene (TNT) is one of the most recalcitrant and toxic of all the military explosives.
French, CE, Susan J. Rosser, Neil C. Bruce, Nerissa Hannink, Bruce, NC, Stephen Nicklin, Hannink, N., Nicklin, S., Rosser, SJ, Bruce, N.C., Murray, JAH, Amrik Basran, Murray, J.A.H., Christopher E. French, Basran, A, Nicklin, S, James A.H. Murray, Rosser, S.J., French, C.E., Hannink, N, Basran, A.   +20 more
core   +1 more source

Dual‐Targeting, Hybrid Antifungal Agents Targeting Candida albicans—An Overview

Chemical Biology &Drug Design, Volume 108, Issue 2, August 2026.
The selective, single‐targeting antifungal agents serve as the parent molecule(s) for the design of dual‐targeting, hybrid fungicidal agents and are discussed and compared, which enables the researchers to understand the logic for designing multi‐targeting new chemical entities (NCEs) that can exhibit dual‐sword attack on Candida albicans. ABSTRACT Due
Sarmistha Pal, Sriparna Pusti, Iftakhar Hussain Ansari, Sanchita Pradhan, Hritabrata Bhattacharya, Shuvradip Das   +5 more
wiley   +1 more source