Results 61 to 70 of about 5,837 (209)

Bystander or No Bystander for Gene Directed Enzyme Prodrug Therapy

Molecules, 2009
Gene directed enzyme prodrug therapy (GDEPT) of cancer aims to improve the selectivity of chemotherapy by gene transfer, thus enabling target cells to convert nontoxic prodrugs to cytotoxic drugs.
Adam V. Patterson, Dean C. Singleton, Sophie Syddall, Michelle A. Hunt, Gabi U. Dachs   +4 more
doaj   +1 more source

Advanced nanotherapeutics for combating ocular infections: Rational design, antimicrobial mechanisms, and therapeutic breakthroughs

BMEMat, EarlyView.
Nanomaterials revolutionize ocular infection treatment by enabling targeted drug delivery and enhanced antimicrobial efficacy against resistant pathogens. This review systematically explores their rational design, multimodal mechanisms, and translational potential for next‐generation anti‐infective therapies.
Yujia Liu, Xuetian Wen, Yue Tan, Rui Zeng, Yijuan Zhang, Tong Lin, Lan Gong, Zichao Luo   +7 more
wiley   +1 more source

Mechanistic Understanding Enables the Rational Design of Salicylanilide Combination Therapies for Gram-Negative Infections

mBio, 2020
One avenue to combat multidrug-resistant Gram-negative bacteria is the coadministration of multiple drugs (combination therapy), which can be particularly promising if drugs synergize.
Janine N. Copp, Daniel Pletzer, Alistair S. Brown, Joris Van der Heijden, Charlotte M. Miton, Rebecca J. Edgar, Michelle H. Rich, Rory F. Little, Elsie M. Williams, Robert E. W. Hancock, Nobuhiko Tokuriki, David F. Ackerley   +11 more
doaj   +1 more source

An unusually cold active nitroreductase for prodrug activations

Bioorganic & Medicinal Chemistry, 2012
A set of PCR primers based on the genome sequence were used to clone a gene encoding a hypothetical nitroreductases (named as Ssap-NtrB) from uropathogenic staphylococcus, Staphylococcus saprophyticus strain ATCC 15305, an oxygen insensitive flavoenzyme. Activity studies of the translation product revealed that the nitroreductase catalyses two electron
Celik, Ayhan, Yetis, Gulden
openaire   +3 more sources

Monosubstituted N‐Arylhydroxylamine Chemistry: Integrating Contemporary Synthetic Approaches for the Efficient Construction of Diverse Heterocyclic Scaffolds

Chemistry – A European Journal, EarlyView.
Monosubstituted N‐arylhydroxylamines represent a unique subclass of hydroxylamines that act as pivotal intermediates in redox transformations and as versatile platforms for further synthetic transformations. They serve as key building blocks in the synthesis of architecturally complex heterocycles and other valuable organic compounds.
Michael G. Kallitsakis, Kyriakos D. Nikopoulos, Ioannis N. Lykakis   +2 more
wiley   +1 more source

Toxicity and degradation of 2,4,6-trinitrotoluene in transgenic Arabidopsis expressing Citrobacter freundii nitroreductase

Biotechnology & Biotechnological Equipment, 2022
The degradation of organic pollutants in plants involves uptake and diffusion through the roots, trunk or leaves, transformation, accumulation and/or volatilization of soil- and aqueous-phase contaminants.
Bo Zhu, Xiyan Hu, Shuanghong You, Jianjie Gao, Xiaoyan Fu, Hongjuan Han, Zhenjun Li, Quanhong Yao   +7 more
doaj   +1 more source

Bioresponsive pseudoGlucosinolates (psGSLs) Release Isothiocyanates (ITCs) in the Presence of Nitroreductases

Chemistry – A European Journal, EarlyView.
This work introduces the concept of pseudoglucosinolates (psGSLs) and reports the synthesis and evaluation of nitroreductase‐responsive psGSLs. These compounds represent a complementary prodrug strategy to natural glucosinolates (GSLs) for the controlled release of isothiocyanates (ITCs), enabling bio‐responsive protein labeling, as demonstrated in ...
Claire C. Jimidar, Charity S. G. Ganskow, Mervic D. Kagho, Aishi Chakrabarti, Lorenz Wiese, Michael Zollo, Ulrike Beutling, Leona C. Cesar, Julia Morud, Kamila Bugaj, Mark Brönstrup, Stephan A. Sieber, Stephan M. Hacker, Philipp Klahn   +13 more
wiley   +1 more source

Development of a Bioluminescent Nitroreductase Probe for Preclinical Imaging

PLOS ONE, 2015
Bacterial nitroreductases (NTRs) have been widely utilized in the development of novel antibiotics, degradation of pollutants, and gene-directed enzyme prodrug therapy (GDEPT) of cancer that reached clinical trials. In case of GDEPT, since NTR is not naturally present in mammalian cells, the prodrug is activated selectively in NTR-transformed cancer ...
Vorobyeva, Anzhelika G., Stanton, Michael, Godinat, Aurélien, Lund, Kjetil B., Karateev, Grigory G., Francis, Kevin P., Allen, Elizabeth, Gelovani, Juri G., McCormack, Emmet, Tangney, Mark, Dubikovskaya, Elena A.   +10 more
openaire   +7 more sources

A nitroreductase and acidity detecting dual functional ratiometric fluorescent probe for selectively imaging tumor cells

, 2018
A dual functional ratiometric fluorescent probe can obviously distinguish acidity, nitroreductase, and nitroreductase in an acidic environment.
Yajie Chou, Guohua Liu, Hanxin Zhou, Zhaoshuai He, Han Zhang, Tanyu Cheng   +5 more
core   +1 more source

Metabolism of nitro drugs metronidazole and nitazoxanide in Giardia lamblia: characterization of a novel nitroreductase (GlNR2). [PDF]

, 2013
OBJECTIVES The protozoan parasite Giardia lamblia causes giardiasis, a persistent diarrhoea. Nitro drugs such as the nitroimidazole metronidazole and the nitrothiazolide nitazoxanide are used for the treatment of giardiasis. Nitroreductases may play a
Müller, Norbert, Schildknecht, Patricia, Müller, Joachim   +2 more
core   +1 more source