Results 71 to 80 of about 6,542 (200)

Development of a Bioluminescent Nitroreductase Probe for Preclinical Imaging

PLOS ONE, 2015
Bacterial nitroreductases (NTRs) have been widely utilized in the development of novel antibiotics, degradation of pollutants, and gene-directed enzyme prodrug therapy (GDEPT) of cancer that reached clinical trials. In case of GDEPT, since NTR is not naturally present in mammalian cells, the prodrug is activated selectively in NTR-transformed cancer ...
Vorobyeva, Anzhelika G., Stanton, Michael, Godinat, Aurélien, Lund, Kjetil B., Karateev, Grigory G., Francis, Kevin P., Allen, Elizabeth, Gelovani, Juri G., McCormack, Emmet, Tangney, Mark, Dubikovskaya, Elena A.   +10 more
openaire   +9 more sources

Safety and efficacy of a feed additive consisting of nicarbazin (NICACOX®) for chickens for fattening and chickens reared for laying (Huvepharma N.V.)

EFSA Journal, Volume 24, Issue 8, August 2026.
Abstract Following a request from the European Commission, EFSA was asked to deliver a scientific opinion on the safety and efficacy of a feed additive consisting of nicarbazin (NICACOX®) as a coccidiostat for chickens for fattening and chickens reared for laying.
EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP), Roberto Edoardo Villa, Giovanna Azimonti, Eleftherios Bonos, Henrik Christensen, Mojca Durjava, Birgit Dusemund, Ronette Gehring, Boet Glandorf, Maryline Kouba, Marta López‐Alonso, Francesca Marcon, Giovanna Martelli, Carlo Nebbia, Alena Pechová, Miguel Prieto‐Maradona, Katerina Theodoridou, Georges Bories, Paul Brantom, Jürgen Gropp, Guido Rychen, Luca Tosti, Ruud Woutersen, Jaume Galobart, Fabiola Pizzo, Alberto Navarro‐Villa, Maria Vittoria Vettori, José Cortiñas Abrahantes, Orsolya Holczknecht   +28 more
wiley   +1 more source

Gut microbial metabolism of Flutamide attenuates its therapeutic efficacy against prostate cancer

Gut Microbes
Endocrine drugs serve as the cornerstone of prostate cancer treatment. Flutamide, a representative first-generation antiandrogen, has been relegated to the treatment of recurrent prostate cancer due to novel drug development and therapeutic resistance ...
Shujing Li, Haiying Ding, Jiaqi Wang, Lingjie Yuan, Ying Zhou, Weiben Xu, Hang Yin, Mengqian Ye, Yuning Sha, Fangyin Li, Yousheng Liu, Zhengqin Zhu, Lulu Song, Xiangyu Jin, Liefeng Ma, Zhajun Zhan, Libin Pan, Luo Fang   +17 more
doaj   +1 more source

Mechanism of Two-/Four-Electron Reduction of Nitroaromatics by Oxygen-Insensitive Nitroreductases: The Role of a Non-Enzymatic Reduction Step

Molecules, 2018
Oxygen-insensitive NAD(P)H:nitroreductases (NR) reduce nitroaromatics (Ar-NO2) into hydroxylamines (Ar-NHOH) through nitroso (Ar-NO) intermediates. Ar-NO may be reduced both enzymatically and directly by reduced nicotinamide adenine dinucleotide or its ...
Benjaminas Valiauga, Lina Misevičienė, Michelle H. Rich, David F. Ackerley, Jonas Šarlauskas, Narimantas Čėnas   +5 more
doaj   +1 more source

Probing 5‐Nitroimidazole‐Triazole Hybrids as Potential Anti‐Kinetoplastid Agents: Synthesis and In Vitro Efficacy

ChemMedChem, Volume 21, Issue 13, 14 July 2026.
A series of 5‐nitroimidazole‐1,2,3‐triazole hybrids was synthesised and evaluated for antitrypanosomatid activity to assess their potential as treatments against leishmaniasis and trypanosomiasis. No notable in vitro activity against Leishmania was detected.
Liandi Ferreira, Gideon D. Badenhorst, Janine Aucamp, Keisuke Suganuma, David D. N’Da   +4 more
wiley   +1 more source

Informing Efforts to Develop Nitroreductase for Amine Production

Molecules, 2018
Nitroreductases (NRs) hold promise for converting nitroaromatics to aromatic amines. Nitroaromatic reduction rate increases with Hammett substituent constant for NRs from two different subgroups, confirming substrate identity as a key determinant of ...
Anne-Frances Miller, Jonathan T. Park, Kyle L. Ferguson, Warintra Pitsawong, Andreas S. Bommarius   +4 more
doaj   +1 more source

Mutagenic activation of CL64,855, an anti-Trypanosoma cruzi nitroderivant, by bacterial nitroreductases

Genetics and Molecular Biology, 1998
CL64,855 is a nitroimidazole-thiodiazole derivate with high anti-Trypanosoma cruzi activity. CL64,855-induced mutagenesis in the Salmonella/microsome test was detected by TA98 and TA98dnp6 strains, but not by the nitroreductase I-deficient TA98nr strain.
Morais Jr. Marcos Antonio de, Ferreira Rita de Cássia Café, Ferreira Luiz Carlos de Souza   +2 more
doaj  

A Host–Guest Platform for Highly Efficient, Quantitative, and Rapid Detection of Nitroreductase

Chemosensors
Nitroreductase (NTR) is an enzyme expressed at an abnormally high level in solid tumors, which is associated with the hypoxia level in tumors. The establishment of a high-performance and convenient fluorescent platform for the fast monitoring of NTR is ...
Wen Si, Yang Jiao, Xianchao Jia, Meng Gao, Yihao Zhang, Ye Gao, Lei Zhang, Chunying Duan   +7 more
doaj   +1 more source

A nitroreductase and acidity detecting dual functional ratiometric fluorescent probe for selectively imaging tumor cells

, 2018
A dual functional ratiometric fluorescent probe can obviously distinguish acidity, nitroreductase, and nitroreductase in an acidic environment.
Yajie Chou, Guohua Liu, Hanxin Zhou, Zhaoshuai He, Han Zhang, Tanyu Cheng   +5 more
core   +1 more source

Asymmetric and Reduced Xanthene Fluorophores: Synthesis, Photochemical Properties, and Application to Activatable Fluorescent Probes for Detection of Nitroreductase

Molecules, 2019
Xanthene fluorophores, including fluorescein, rhodol, and rhodamines, are representative classes of fluorescent probes that have been applied in the detection and visualization of biomolecules.
Kunal N. More, Tae-Hwan Lim, Julie Kang, Hwayoung Yun, Sung-Tae Yee, Dong-Jo Chang   +5 more
doaj   +1 more source