Results 71 to 80 of about 6,658 (162)
General strategy for imaging of NTR activity with Nitroreductase Caged Luciferin (NCL) probe.
, 2015 General strategy for imaging of NTR activity with Nitroreductase Caged Luciferin (NCL) probe.
Anzhelika G. Vorobyeva (760629) +10 more
core +1 more source
Gut MicrobesThe intestinal environment determines the biochemical activity of individual microbial strains. The functions of microbial strains in their native environments often cannot be accurately predicted based solely on genomic information or the biochemical ...
Chuanjia Zhai +12 more
doaj +1 more source
Use of nfsB, encoding nitroreductase, as a reporter gene to determine the mutational spectrum of spontaneous mutations in Neisseria gonorrhoeae [PDF]
, 2009 Background: Organisms that are sensitive to nitrofurantoin express a nitroreductase. Since bacterial resistance to this compound results primarily from mutations in the gene encoding nitroreductase, the resulting loss of function of nitroreductase ...
Stein, Daniel C +2 more
core
, 2016 Cyclic and acyclic nitroaryl phosphoramide mustard analogues were activated by E. coli nitroreductase, an enzyme explored in GDEPT. The more active acyclic 4-nitrobenzyl phosphoramide mustard (7) showed 167 500× selective cytotoxicity toward ...
Jiye Han (2535457) +9 more
core +1 more source
Oncolytic adenovirus vectors for nitroreductase suicide gene therapy of prostate cancer [PDF]
, 2010 Prostate cancer is the most common male cancer in the UK and USA, with a 1/13 chance of diagnosis and a 1/30 lifetime risk of death from the disease. Current treatment options include radiotherapy, surgery and hormone therapy, however 1/3 patients escape
Herod, Morgan Reece
core +4 more sources
Cell-Specific Chemical Delivery Using a Selective Nitroreductase–Nitroaryl Pair [PDF]
, 2018 The utility of small molecules to probe or perturb biological systems is limited by the lack of cell-specificity. ‘Masking’ the activity of small molecules using a general chemical modification and ‘unmasking’ it only within target cells could overcome ...
Michael R., Tadross +6 more
core +2 more sources
Application of enzyme-responsive fluorescent probes in detecting drug-resistant bacteria
Nantong Daxue xuebao. Ziran kexue banWith the overuse of clinical antibiotics, the types and varieties of drug-resistant bacteria are continually increasing. The timely and accurate identification of bacterial strains is crucial for the prevention and control of drug-resistant bacteria and ...
GUAN Jiayun;ZHANG Jingyi;WANG Li;YU Yanyang;WANG Qi;QIN Yuling;WU Li
doaj +1 more source
, 2019 Development of a highly selective and sensitive imaging probe for accurate detection of myocardial hypoxia will be helpful to estimate the degree of ischemia and subsequently guide personalized treatment.
Mi Lu +17 more
core +1 more source
A mammalianized synthetic nitroreductase gene for high-level expression
BMC Cancer, 2009 Background The nitroreductase/5-(azaridin-1-yl)-2,4-dinitrobenzamide (NTR/CB1954) enzyme/prodrug system is considered as a promising candidate for anti-cancer strategies by gene-directed enzyme prodrug therapy (GDEPT) and has recently entered clinical ...
Grohmann Maik +5 more
doaj +1 more source
Genetics and Molecular Biology, 1998 CL64,855 is a nitroimidazole-thiodiazole derivate with high anti-Trypanosoma cruzi activity. CL64,855-induced mutagenesis in the Salmonella/microsome test was detected by TA98 and TA98dnp6 strains, but not by the nitroreductase I-deficient TA98nr strain.
Morais Jr. Marcos Antonio de +2 more
doaj