Results 71 to 80 of about 5,837 (209)
Bioinformatic analysis and characterization of the enzyme SE1966 - A putative nitroreductase
, 2022 The Protein Structure Initiative (PSI) was a 15 year, $70 million program with the goal of solving large numbers of protein structures, expanding basic and biomedical research.
Langlois, Allison
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Journal of Functional Biomaterials, 2019 Directed enzyme prodrug therapy (DEPT) involves the delivery of a prodrug-activating enzyme to a solid tumour site, followed by the subsequent activation of an administered prodrug.
Simon D. Anderson +6 more
doaj +1 more source
Implantable drug delivery system: Frontiers of medicine‐engineering interdisciplinary
Interdisciplinary Medicine, EarlyView.This review systematically summarizes the driving mechanisms of implantable on‐demand drug delivery systems (IDDS), including endogenous, exogenous, and closed‐loop strategies. It highlights the pivotal roles of flexible electronics and miniaturization in enhancing the tissue conformity and spatial adaptability.
Yu Zeng +9 more
wiley +1 more source
Mass Spectrometry Reviews, EarlyView.ABSTRACT Nitrooxidative stress, driven by excess reactive nitrogen species like peroxynitrite, contributes to the pathogenesis of many chronic diseases. Among its molecular footprints, 3‐nitrotyrosine (3NT) has emerged as a biologically relevant marker of protein nitration.
Brîndușa Alina Petre
wiley +1 more source
X-ray crystallographic studies of therapeutic enzymes: nitroreductase and AKR1C3 [PDF]
, 2003 The \(Escherichia\) \(coli\) enzyme nitroreductase has been proposed as a candidate for the Gene-Directed Enzyme Prodrug Therapy approach in treating cancer.
Lovering, Andrew, Lovering, Andrew Lee
core
Proteins: Structure, Function, and Bioinformatics, EarlyView.ABSTRACT BorF is a short‐chain flavin reductase from a desert soil bacterium that uses NADH to reduce FAD to FADH2, which is used by the tryptophan‐6‐halogenase BorH to chlorinate tryptophan in the biosynthetic pathway of borregomycin A. The X‐ray crystal structure of BorF bound to FAD was solved to 2.37 Å by molecular replacement.
Zheng Ma +3 more
wiley +1 more source
Responsive Materials, EarlyView.This review summarizes the recent progress in responsive NO‐releasing materials and their applications in biofilm‐associated infectious diseases. The design principles and response mechanisms are given to provide inspiration toward the future development of multi‐responsive NO‐releasing materials.
Wenyue Sun +8 more
wiley +1 more source
imaging. The terbium-based luminescent probe is non-fluorescent in its inactive state but can be selectively activated by nitroreductase, leading to the release of the sensitizing antenna that facilitates energy transfer to the lanthanide center ...
Qian, Liu +5 more
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Molecular Periphery Design Allows Control of the New Nitrofurans Antimicrobial Selectivity
MoleculesA series of 13 new 3-substituted 5-(5-nitro-2-furyl)-1,2,4-oxadiazoles was synthesized from different aminonitriles. All compounds were screened in the disc diffusion test at a 100 μg/mL concentration to determine the bacterial growth inhibition zone ...
Lyubov Vinogradova +11 more
doaj +1 more source
Peptide‐based responsive molecular fluorescent probes for precision oncology
Responsive Materials, EarlyView.Peptide‐based responsive fluorescent probes have emerged as adaptive functional materials for precision tumor theranostics, combining tumor‐selective recognition, programmable stimulus responsiveness, and modular tunability. They enable high‐contrast imaging, intraoperative guidance, real‐time monitoring, and multimodal applications, while next ...
Xing Wang +6 more
wiley +1 more source