Results 91 to 100 of about 6,542 (200)
Nitroreductases as alkoxyamine-selective triggers
New Journal of ChemistryNitroreductase-mediated alkoxyamine activation: a selective approach for prodrugs.
Marion Siccardi +5 more
openaire +1 more source
, 2015 Hypoxia plays an important role in tumor progression, and the development of efficient methods for monitoring hypoxic degree in living systems is of great biomedical importance.
Xiao-Xiao Hu (1473037) +6 more
core +1 more source
Oncolytic adenovirus vectors for nitroreductase suicide gene therapy of prostate cancer [PDF]
, 2010 Prostate cancer is the most common male cancer in the UK and USA, with a 1/13 chance of diagnosis and a 1/30 lifetime risk of death from the disease. Current treatment options include radiotherapy, surgery and hormone therapy, however 1/3 patients escape
Herod, Morgan Reece
core +2 more sources
, 2019 Development of a highly selective and sensitive imaging probe for accurate detection of myocardial hypoxia will be helpful to estimate the degree of ischemia and subsequently guide personalized treatment.
Mi Lu +17 more
core +1 more source
Activation of 1-nitropyrene by nitroreductase increases the DNA adduct level and mutagenicity [PDF]
, 1998 1-Nitropyrene (1-NP) is a mutagenic nitro compound in the environment. We studied correlations between the mutagenicity of 1-NP for three strains of Salmonella typhimurium, the activity of bacterial nitroreductases and the amount of 1-NP-derived DNA ...
Ohnishi, Yoshinari +21 more
core
An inducible model of chronic hyperglycemia
Disease Models & Mechanisms, 2023 Tori R. Tucker +9 more
doaj +1 more source
Fast analysis of nitrobenzene by nitroreductase modified electrode
, 2011 Nitroreductase (NR) was modified on glass carbon electrode and used in nitrobenzene analysis. Both cyclic voltammetry (CV) and triple potential step chronocoulometry (TPSC) with a narrow potential step interval were used.
Liu, C. M. +7 more
core +1 more source
, 2012 Thermotoga maritima peroxiredoxin–nitroreductase hybrid enzyme (Prx–NR) consists of a FMN-containing nitroreductase (NR) domain fused to a peroxiredoxin (Prx) domain. These domains seem to function independently as no electron transfer occurs between them.
Anusevicius, Zilvinas +3 more
openaire +2 more sources
Chemodosimeter-based fluorescent probes for esterase, nitroreductase and tyrosinase
This review summerizes recent advances in chemodosimeter-based fluorescent probes for esterase, nitroreductase, and tyrosinase enzyme detection and their bioimaging applications, including current challenges and future directions.
Dipanjan Banik +3 more
core +1 more source
The gene suicide system NTR/CB1954 causes ablation of differentiated 3T3L1 adipocytes by apoptosis
Biological Research, 2004 The feasibility of ablating differentiated adipocytes and the mechanism of cell ablation with a suitable prodrug activating system is described. The system is based on the use of E. coli nitroreductase (NTR) enzyme that activates certain nitro compounds,
RICARDO N FELMER, JOHN A CLARK
doaj