Results 91 to 100 of about 5,837 (209)
Structural insights into urocanate reductase using room‐temperature X‐ray crystallography
Acta Crystallographica Section D, Volume 82, Issue 6, Page 603-614, June 2026.The active‐site dynamics of the microbial enzyme urocanate reductase were revealed by room‐temperature X‐ray crystallography.Urocanate reductase (UrdA) is a bacterial enzyme that converts urocanic acid to imidazole propionate. Its catalytic residue Arg411 undergoes a large conformational change in the substrate‐bound versus product‐bound states.
Swati Aggarwal +4 more
wiley +1 more source
, 2019 Development of a highly selective and sensitive imaging probe for accurate detection of myocardial hypoxia will be helpful to estimate the degree of ischemia and subsequently guide personalized treatment.
Mi Lu +17 more
core +1 more source
Genetics and Molecular Biology, 1998 CL64,855 is a nitroimidazole-thiodiazole derivate with high anti-Trypanosoma cruzi activity. CL64,855-induced mutagenesis in the Salmonella/microsome test was detected by TA98 and TA98dnp6 strains, but not by the nitroreductase I-deficient TA98nr strain.
Morais Jr. Marcos Antonio de +2 more
doaj
A Host–Guest Platform for Highly Efficient, Quantitative, and Rapid Detection of Nitroreductase
ChemosensorsNitroreductase (NTR) is an enzyme expressed at an abnormally high level in solid tumors, which is associated with the hypoxia level in tumors. The establishment of a high-performance and convenient fluorescent platform for the fast monitoring of NTR is ...
Wen Si +7 more
doaj +1 more source
Activation of 1-nitropyrene by nitroreductase increases the DNA adduct level and mutagenicity [PDF]
, 1998 1-Nitropyrene (1-NP) is a mutagenic nitro compound in the environment. We studied correlations between the mutagenicity of 1-NP for three strains of Salmonella typhimurium, the activity of bacterial nitroreductases and the amount of 1-NP-derived DNA ...
Ohnishi, Yoshinari +21 more
core
Molecules, 2019 Xanthene fluorophores, including fluorescein, rhodol, and rhodamines, are representative classes of fluorescent probes that have been applied in the detection and visualization of biomolecules.
Kunal N. More +5 more
doaj +1 more source
NITROREDUCTASE NfnB FROM Mycobacterium smegmatis
, 2008 The present invention relates to a screening method for the identification of new nitrobenzothiazinone drugs for the treatment of tuberculosis, which are not or are slowly transformed and inactivated by nitroreductase.
PASCA, MARIA ROSALIA +2 more
core
, 2010 In Lactococcus lactis IL1403, 14 genes are under the control of the copper-inducible CopR repressor. This so-called CopR regulon encompasses the CopR regulator, two putative CPx-type copper ATPases, a copper chaperone, and 10 additional genes of unknown ...
Oberholzer, Anselm E +11 more
core +1 more source
Oncolytic adenovirus vectors for nitroreductase suicide gene therapy of prostate cancer [PDF]
, 2010 Prostate cancer is the most common male cancer in the UK and USA, with a 1/13 chance of diagnosis and a 1/30 lifetime risk of death from the disease. Current treatment options include radiotherapy, surgery and hormone therapy, however 1/3 patients escape
Herod, Morgan Reece
core
Nitroreductase reactions of Arabidopsis thaliana thioredoxin reductase
Biochimica et Biophysica Acta (BBA) - Bioenergetics, 1998 Arabidopsis thaliana NADPH:thioredoxin reductase (TR, EC 1.6.4.5) catalyzed redox cycling of aromatic nitrocompounds, including the explosives 2,4,6-trinitrotoluene and tetryl, and the herbicide 3,5-dinitro-o-cresol. The yield of nitro anion radicals was equal to 70-90%.
Miškinien≐, Vanda +3 more
openaire +2 more sources