Results 111 to 120 of about 5,837 (209)

General strategy for imaging of NTR activity with Nitroreductase Caged Luciferin (NCL) probe.

, 2015
General strategy for imaging of NTR activity with Nitroreductase Caged Luciferin (NCL) probe.
Anzhelika G. Vorobyeva (760629), Elena A. Dubikovskaya (760634), Mark Tangney (186580), Michael Stanton (760630), Kjetil B. Lund (760632), Juri G. Gelovani (207491), Aurélien Godinat (760631), Grigory G. Karateev (760633), Kevin P. Francis (129761), Elizabeth Allen (59854), Emmet McCormack (121035)   +10 more
core   +1 more source

E. coli nitroreductase NfsA is a reporter gene for non-invasive PET imaging in cancer gene therapy applications

, 2020
The use of reporter genes to non-invasively image molecular processes inside cells has significant translational potential, particularly in the context of systemically administered gene therapy vectors and adoptively administered cells such as immune or ...
Smaill, Jeff Bruce, Abbattista, Maria Rosaria, Mowday, Alexandra Marie, Lieuwes, Natasja Gabi, Patterson, Adam Vorn, Syddall, Sophie Philippa, Ashoorzadeh, Amir, Copp, Janine Naomi, Guise, Christopher Paul, Biemans, Rianne, Wang, Jingli, Lambin, Philippe, Dubois, Ludwig Jerome, Williams, Elsie May, Theys, Jan; id_orcid, Ackerley, David Francis, Theys, Jan   +16 more
core   +1 more source

Application of enzyme-responsive fluorescent probes in detecting drug-resistant bacteria

Nantong Daxue xuebao. Ziran kexue ban
With the overuse of clinical antibiotics, the types and varieties of drug-resistant bacteria are continually increasing. The timely and accurate identification of bacterial strains is crucial for the prevention and control of drug-resistant bacteria and ...
GUAN Jiayun;ZHANG Jingyi;WANG Li;YU Yanyang;WANG Qi;QIN Yuling;WU Li
doaj   +1 more source

Biocatalytic Reduction of a Non-aromatic Nitro Group by a Nitroreductase from Salmonella Typhimurium

, 2014
Biocatalytic reduction of a non-aromatic nitro group by a nitroreductase from Salmonella typhimurium. A nitroreductase from Salmonella typhimurium (NRSal) was studied for its ability to reduce an aliphatic nitro ...
Reams, Thomas, Oliff, Ryan
core  

In Vivo Chemiluminescent Imaging Agents for Nitroreductase and Tissue Oxygenation

, 2016
Tissue oxygenation is a driving parameter of the tumor microenvironment, and hypoxia can be a prognostic indicator of aggressiveness, metastasis, and poor response to therapy.
Li Liu (75607), James Campbell (81613), Ralph P. Mason (131100), Jian Cao (16485), Alexander R. Lippert (2040712)   +4 more
core   +1 more source

Design, synthesis, and biological evaluation of cyclic and acyclic nitrobenzylphosphoramide mustards for E. coli nitroreductase activation

, 2006
In efforts to obtain anticancer prodrugs for antibody-directed or gene-directed enzyme prodrug therapy using E. coli nitroreductase, a series of nitrobenzylphosphoramide mustards were designed and synthesized incorporating a strategically placed nitro ...
Jiang, Y, Browne, P, Han, J, Knox, RJ, Hu, L, Vass, Simon, Searle, Peter, Yu, C   +7 more
core   +1 more source

An inducible model of chronic hyperglycemia

Disease Models & Mechanisms, 2023
Tori R. Tucker, Courtney A. Knitter, Deena M. Khoury, Sheida Eshghi, Sophia Tran, Abigail V. Sharrock, Travis J. Wiles, David F. Ackerley, Jeff S. Mumm, Michael J. Parsons   +9 more
doaj   +1 more source

The expression of bacterial nitroreductase in eukaryotic cells results in their killing by the prodrug CB1954.

, 1997
The enzyme nitroreductase, isolated from Escherichia coli B, converts CB1954 ((5-aziridin-1-yl)-2,4-dinitro-benzamide) into a cytotoxic DNA interstrand cross-linking agent. The E.
Drabek, D.D. (Dubravka), Guy, J.A. (Jacqueline), Grosveld, F.G. (Frank)   +2 more
core  

Two-electron reduction of nitroaromatic compounds by Thermotoga maritima hybrid peroxiredoxin-nitroreductase enzyme

, 2011
International audienceExplosives such as 2,4,6-trinitrotoluene (TNT) and related polynitroaromatics being toxic environmental pollutants, numerous efforts are directed towards their biodegradation.
Anusevicius, Zilvinas, Cenas, Narimantas, Miseviciene, Lina, Sarlauskas, Jonas, Jacquot, Jean-Pierre, Rouhier, Nicolas   +5 more
core   +1 more source

Structures of Nitroreductase in Three States [PDF]

Journal of Biological Chemistry, 2002
Chad A. Haynes, Ronald L. Koder, Anne-Frances Miller, David W. Rodgers   +3 more
openaire   +1 more source