Results 121 to 130 of about 5,837 (209)

The gene suicide system NTR/CB1954 causes ablation of differentiated 3T3L1 adipocytes by apoptosis

Biological Research, 2004
The feasibility of ablating differentiated adipocytes and the mechanism of cell ablation with a suitable prodrug activating system is described. The system is based on the use of E. coli nitroreductase (NTR) enzyme that activates certain nitro compounds,
RICARDO N FELMER, JOHN A CLARK
doaj  

A genetic reporter for visualizing nitroreductase activity using magnetic resonance imaging. [PDF]

Chem Methods
Wan J, Chacko AN, Xu E, Kuriakose K, Mukherjee A.   +4 more
europepmc   +1 more source

5‑Nitrofuran-Semicarbazone Hybrids as Antitrypanosomal Agents: Structure-Activity Relationship and Nitroreductase Activation. [PDF]

ACS Med Chem Lett
Alegbejo Price TO, Silva DG, Vaidergorn MM, Augusto BS, Matheeussen A, Van Pelt N, Caljon G, Riley J, Read KD, Medina-Franco JL, Nonato MC, Emery FS.   +11 more
europepmc   +1 more source

Near-Infrared and Shortwave Infrared Building Blocks for Activity-Based Sensors in Animals. [PDF]

Bioconjug Chem
Wang T, Li X, Guo L, Jia S.
europepmc   +1 more source

Nitroaryl Phosphoramides as Novel Prodrugs for E. coli Nitroreductase Activation in Enzyme Prodrug Therapy

, 2003
Cyclic and acyclic nitroaryl phosphoramide mustard analogues were activated by E. coli nitroreductase, an enzyme explored in GDEPT. The more active acyclic 4-nitrobenzyl phosphoramide mustard (7) showed 167 500x selective cytotoxicity toward ...
Jiang Y, Browne P, Searle PF, Li Z, Yu C, Race PR, Knox RJ, Hyde EI, Hu L, Han J   +9 more
core  

Correction: A mitochondria targeted nitroreductase-sensitive self-immolative spacer as an efficient shuttle for uncharged amine-based molecules. [PDF]

Chem Sci
Michel L, Steinmetz V, Godel-Pastre S, Durand P, Chevalier A.   +4 more
europepmc   +1 more source

Characterization of nitroreductase gene A of <i>Enterococcus faecalis</i> isolates from fecal samples of patients with colorectal cancer and healthy people. [PDF]

Open Life Sci
Li P, Li X, Li J, Tan Y, Li M.
europepmc   +1 more source

Smart CaCO₃-coated probiotics relieve constipation by enhancing intestinal motility and modulating microbial enzymes in a loperamide-induced rat model. [PDF]

Sci Rep
Jeong SN, Kim MJ.
europepmc   +1 more source

Biodegradation mechanism of butralin by a newly isolated <i>Bacillus velezensis</i> FC02. [PDF]

RSC Adv
Tan F, Ling W, Zong H, Xu C, Yu J, Cao H, Chen D, Feng C.   +7 more
europepmc   +1 more source

Oxidative Peptide Backbone Cleavage by a HEXXH Enzyme during RiPP Biosynthesis. [PDF]

J Am Chem Soc
Ouyang Y, Yu Y, Zhu L, Nguyen DT, van der Donk WA.   +4 more
europepmc   +1 more source