Results 81 to 90 of about 6,542 (200)

NITROREDUCTASE NfnB FROM Mycobacterium smegmatis

, 2008
The present invention relates to a screening method for the identification of new nitrobenzothiazinone drugs for the treatment of tuberculosis, which are not or are slowly transformed and inactivated by nitroreductase.
PASCA, MARIA ROSALIA, MANINA, GIULIA, RICCARDI, GIOVANNA   +2 more
core  

Abstracts

Molecular Oncology, Volume 20, Issue S1, Page 1-692, August 2026.
Abstracts submitted to the ‘EACR 2026 Congress: Innovative Cancer Science’, from 08–11 June 2026 and accepted by the Congress Organising Committee are published in this Supplement of Molecular Oncology, an affiliated journal of the European Association for Cancer Research (EACR).
wiley   +1 more source

Unraveling Mechanisms and Epidemic Characteristics of Nitrofurantoin Resistance in Uropathogenic Enterococcus faecium Clinical Isolates

Infection and Drug Resistance, 2021
Ying Zhang,1 Lingbo Wang,2 Cui Zhou,2 Yishuai Lin,1 Shixing Liu,2 Weiliang Zeng,1 Kaihang Yu,1 Tieli Zhou,2 Jianming Cao1 1Department of Medical Lab Science, School of Laboratory Medicine and Life Science, Wenzhou Medical University, Wenzhou, Zhejiang ...
Zhang Y, Wang L, Zhou C, Lin Y, Liu S, Zeng W, Yu K, Zhou T, Cao J   +8 more
doaj  

19F NMR Chemical Shift-encoded cRGD-targeted Dual-modal Probe for Multicolor Imaging

Chinese Journal of Magnetic Resonance
Specific imaging of the tumor microenvironment is critical for precise cancer diagnosis, yet conventional single-modal imaging techniques struggle to combine high sensitivity with high spatial resolution.
LI Na, XIAO Long, LI Sha, LIU Yudun, JIA Yushu, ZHANG Lei, CHEN Shizhen   +6 more
doaj   +1 more source

Confirmation of Frm2 as a novel nitroreductase in Saccharomyces cerevisiae

, 2012
Nitroreductases comprise a group of FMN- or FAD-dependent enzymes that reduce nitrosubstituted compounds by using NAD(P)H, and are found in bacterial species and yeast.
J S Lee, Byoung Chul Park, D H Lee, P K Myung, Seo Young Bang, Phil Young Lee, Jeong Hoon Kim, Kwang-Hee Bae, P S Kim, Sung Goo Park   +9 more
core   +1 more source

In situ identifying sennoside A-reducing bacteria guilds in human gut microbiota via enzymatic activity visualization

Gut Microbes
The intestinal environment determines the biochemical activity of individual microbial strains. The functions of microbial strains in their native environments often cannot be accurately predicted based solely on genomic information or the biochemical ...
Chuanjia Zhai, Xinyue Liu, Zhen Liu, Huilin Ma, Huajinzi Li, Yingxi Gong, Xiang Li, Yingyue Wang, Na Zhang, Han Zhang, Gan Luo, Ying Wang, Xiaoyan Gao   +12 more
doaj   +1 more source

Self-Assembled Fluorophore-Based Probe for Efficient Detection of Endogenous Nitroreductase Activity in Escherichia Coli [PDF]

Fluorescent probes are functional molecules whose fluorescent properties are transformed as a response to specific stimuli. Understanding the mechanisms of these transformations is essential for the design of these stimuli-responsive fluorescent probes ...
Asif, Mashal, Hori, Hitoshi, Kariyazono, Hirokazu, Uto, Yoshihiro, Nakata, Eiji, Yukimachi, Yoshihiro, Komatsubara, Futa, Nazumi, Yoshijiro   +7 more
core   +1 more source

Flavin-Dependent Nitroreductases

ChemCatChem
Nitroreductases, present within both prokaryotes and eukaryotes, form a group of flavin-dependent enzymes capable of reducing nitro compounds using NAD(P)H as reducing agent. These enzymes have been widely studied due to their diverse roles in bioremediation, cancer therapy, cell ablation, and antimicrobial resistance.
Russo, Sara, Luján, Alejandro Prats, Fraaije, Marco W., Poelarends, Gerrit J.   +3 more
openaire   +1 more source

A coelenterazine-type bioluminescent probe for nitroreductase imaging

, 2018
Novel coelenterazine-type bioluminescent probes have been designed and synthesized to detect nitroreductase (NTR) in hypoxic tumors.
Zhenzhen Li, Tianyu Jiang, Lupei Du, Xingye Yang, Minyong Li   +4 more
core   +1 more source

Application of enzyme-responsive fluorescent probes in detecting drug-resistant bacteria

Nantong Daxue xuebao. Ziran kexue ban
With the overuse of clinical antibiotics, the types and varieties of drug-resistant bacteria are continually increasing. The timely and accurate identification of bacterial strains is crucial for the prevention and control of drug-resistant bacteria and ...
GUAN Jiayun;ZHANG Jingyi;WANG Li;YU Yanyang;WANG Qi;QIN Yuling;WU Li
doaj   +1 more source