Results 81 to 90 of about 6,658 (162)

Self-Assembled Fluorophore-Based Probe for Efficient Detection of Endogenous Nitroreductase Activity in Escherichia Coli [PDF]

Fluorescent probes are functional molecules whose fluorescent properties are transformed as a response to specific stimuli. Understanding the mechanisms of these transformations is essential for the design of these stimuli-responsive fluorescent probes ...
Asif, Mashal, Hori, Hitoshi, Kariyazono, Hirokazu, Uto, Yoshihiro, Nakata, Eiji, Yukimachi, Yoshihiro, Komatsubara, Futa, Nazumi, Yoshijiro   +7 more
core   +1 more source

The expression of bacterial nitroreductase in eukaryotic cells results in their killing by the prodrug CB1954.

, 1997
The enzyme nitroreductase, isolated from Escherichia coli B, converts CB1954 ((5-aziridin-1-yl)-2,4-dinitro-benzamide) into a cytotoxic DNA interstrand cross-linking agent. The E.
Drabek, D.D. (Dubravka), Guy, J.A. (Jacqueline), Grosveld, F.G. (Frank)   +2 more
core   +1 more source

Chemodosimeter-based fluorescent probes for esterase, nitroreductase and tyrosinase

This review summerizes recent advances in chemodosimeter-based fluorescent probes for esterase, nitroreductase, and tyrosinase enzyme detection and their bioimaging applications, including current challenges and future directions.
Dipanjan Banik, Loknath Pakhira, Pintu Ghosh, Ajit Kumar Mahapatra   +3 more
core   +1 more source

A Host–Guest Platform for Highly Efficient, Quantitative, and Rapid Detection of Nitroreductase

Chemosensors
Nitroreductase (NTR) is an enzyme expressed at an abnormally high level in solid tumors, which is associated with the hypoxia level in tumors. The establishment of a high-performance and convenient fluorescent platform for the fast monitoring of NTR is ...
Wen Si, Yang Jiao, Xianchao Jia, Meng Gao, Yihao Zhang, Ye Gao, Lei Zhang, Chunying Duan   +7 more
doaj   +1 more source

Abstracts

Molecular Oncology, Volume 20, Issue S1, Page 1-692, August 2026.
Abstracts submitted to the ‘EACR 2026 Congress: Innovative Cancer Science’, from 08–11 June 2026 and accepted by the Congress Organising Committee are published in this Supplement of Molecular Oncology, an affiliated journal of the European Association for Cancer Research (EACR).
wiley   +1 more source

Two-electron reduction of nitroaromatic compounds by Thermotoga maritima hybrid peroxiredoxin-nitroreductase enzyme

, 2011
International audienceExplosives such as 2,4,6-trinitrotoluene (TNT) and related polynitroaromatics being toxic environmental pollutants, numerous efforts are directed towards their biodegradation.
Anusevicius, Zilvinas, Cenas, Narimantas, Miseviciene, Lina, Sarlauskas, Jonas, Jacquot, Jean-Pierre, Rouhier, Nicolas   +5 more
core   +1 more source

Efficient Two-Photon Fluorescent Probe for Nitroreductase Detection and Hypoxia Imaging in Tumor Cells and Tissues

, 2015
Hypoxia plays an important role in tumor progression, and the development of efficient methods for monitoring hypoxic degree in living systems is of great biomedical importance.
Xiao-Xiao Hu (1473037), Li-Hui Liang (1473040), Hong-Wen Liu (259126), Jing Zhang (23775), Jin Li (119007), Weihong Tan (9692), Xiao-Bing Zhang (62495)   +6 more
core   +1 more source

Design, synthesis, and biological evaluation of cyclic and acyclic nitrobenzylphosphoramide mustards for E. coli nitroreductase activation

, 2006
In efforts to obtain anticancer prodrugs for antibody-directed or gene-directed enzyme prodrug therapy using E. coli nitroreductase, a series of nitrobenzylphosphoramide mustards were designed and synthesized incorporating a strategically placed nitro ...
Jiang, Y, Browne, P, Han, J, Knox, RJ, Hu, L, Vass, Simon, Searle, Peter, Yu, C   +7 more
core   +1 more source

Nitroaryl Phosphoramides as Novel Prodrugs for E. coli Nitroreductase Activation in Enzyme Prodrug Therapy

, 2003
Cyclic and acyclic nitroaryl phosphoramide mustard analogues were activated by E. coli nitroreductase, an enzyme explored in GDEPT. The more active acyclic 4-nitrobenzyl phosphoramide mustard (7) showed 167 500x selective cytotoxicity toward ...
Jiang Y, Browne P, Searle PF, Li Z, Yu C, Race PR, Knox RJ, Hyde EI, Hu L, Han J   +9 more
core   +1 more source

Nitroaryl phosphoramides as novel prodrugs for E. coli nitroreductase activation in enzyme prodrug therapy

, 2003
Cyclic and acyclic nitroaryl phosphoramide mustard analogues were activated by E. coli nitroreductase, an enzyme explored in GDEPT. The more active acyclic 4-nitrobenzyl phosphoramide mustard (7) showed 167 500x selective cytotoxicity toward ...
Race, Paul, Jiang, Y, Li, Z, Browne, P, Hu, L, Han, J, Knox, RJ, Searle, Peter, Hyde, Eva, Yu, C   +9 more
core   +1 more source