Results 51 to 60 of about 6,542 (200)

Design, Synthesis, and Evaluation of Doxifluridine Derivatives as Nitroreductase-Responsive Anticancer Prodrugs

Molecules
Antimetabolite antitumor drugs interfere with nucleic acid and DNA synthesis, causing cancer cell death. However, they also affect rapidly dividing normal cells and cause serious side effects.
Xinmeng Zhang, Taimin Dong, Xu Li, Changjie Xu, Fanghui Chen, Shiben Wang, Xuekun Wang   +6 more
doaj   +1 more source

Proteomics of Nitrotyrosine: Integrating Mass Spectrometry and Immunodetection in Redox‐Driven Pathology

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Nitrooxidative stress, driven by excess reactive nitrogen species like peroxynitrite, contributes to the pathogenesis of many chronic diseases. Among its molecular footprints, 3‐nitrotyrosine (3NT) has emerged as a biologically relevant marker of protein nitration.
Brîndușa Alina Petre
wiley   +1 more source

Nitroreductase-Activatable Theranostic Molecules with High PDT Efficiency under Mild Hypoxia Based on a TADF Fluorescein Derivative

, 2019
High specificity detection and site-specific therapy are still the main challenges for theranostic anticancer prodrugs. In this work, we reported two smart activatable theranostic molecules based on a thermally activated delayed fluorescence fluorescein ...
Gagik Gurzadyan, Huiyi Yin, Ri Liang (6593045), Bo Song, Zhiwei Liu, Huiyi Yin (6593042), Bo Song (255492), Wenbo Shi, Zhiwei Liu (151279), Gagik Gurzadyan (2457802), Xiaojun Peng (721101), Fengling Song, Xiaojun Peng, Wenbo Shi (1437217), Ri Liang, Fengling Song (1781350)   +15 more
core   +1 more source

Nitroreduction of flutamide by Cunninghamella elegans NADPH: Cytochrome P450 reductase

Biochemistry and Biophysics Reports, 2022
The microbial model of mammalian drug metabolism, Cunninghamella elegans, has three cytochrome P450 reductase genes in its genome: g1631 (CPR_A), g4301 (CPR_B), and g7609 (CPR_C).
Mohd Faheem Khan, Cormac D. Murphy
doaj   +1 more source

Advancing Therapies for Mycobacterial Diseases: From Small Molecules to Host‐Directed Strategies

Medicinal Research Reviews, EarlyView.
ABSTRACT The global burden of multidrug‐resistant tuberculosis (MDR‐TB) and the rising incidence of nontuberculous mycobacterial (NTM) infections highlight the urgent need for innovative therapeutic strategies. Current treatments are prolonged, toxic, and increasingly compromised by resistance and limited diagnostic capacity.
Tânia Silva, Alessandra Aiello, Tonino Alonzi, M. Alice Carvalho, Vladimir Finger, Delia Goletti, Sven Hoffner, Yousra Kherabi, Jan Korabecny, Julia Kulczyńska, Agnieszka Kyzioł, Alicia Lacoma, Filomena Martins, Zorica Nanovic, Sepideh Hosseiniporgham, Martina Hrast Rambaher, Leonardo Antonio Sechi, Daria Smalchuk, Grażyna Stochel, Lydia Tabernero, Nancy L. Tateosian, Violeta Valcheva, Anamarija Zega, Mafalda Sarraguça   +23 more
wiley   +1 more source

Bystander or No Bystander for Gene Directed Enzyme Prodrug Therapy

Molecules, 2009
Gene directed enzyme prodrug therapy (GDEPT) of cancer aims to improve the selectivity of chemotherapy by gene transfer, thus enabling target cells to convert nontoxic prodrugs to cytotoxic drugs.
Adam V. Patterson, Dean C. Singleton, Sophie Syddall, Michelle A. Hunt, Gabi U. Dachs   +4 more
doaj   +1 more source

Mechanistic Understanding Enables the Rational Design of Salicylanilide Combination Therapies for Gram-Negative Infections

mBio, 2020
One avenue to combat multidrug-resistant Gram-negative bacteria is the coadministration of multiple drugs (combination therapy), which can be particularly promising if drugs synergize.
Janine N. Copp, Daniel Pletzer, Alistair S. Brown, Joris Van der Heijden, Charlotte M. Miton, Rebecca J. Edgar, Michelle H. Rich, Rory F. Little, Elsie M. Williams, Robert E. W. Hancock, Nobuhiko Tokuriki, David F. Ackerley   +11 more
doaj   +1 more source

Cell-Penetrating Peptides as a Tool for the Cellular Uptake of a Genetically Modified Nitroreductase for use in Directed Enzyme Prodrug Therapy

Journal of Functional Biomaterials, 2019
Directed enzyme prodrug therapy (DEPT) involves the delivery of a prodrug-activating enzyme to a solid tumour site, followed by the subsequent activation of an administered prodrug.
Simon D. Anderson, Robert J. Hobbs, Vanessa V. Gwenin, Patrick Ball, Lindsey A. Bennie, Jonathan A. Coulter, Chris D. Gwenin   +6 more
doaj   +1 more source

Toxicity and degradation of 2,4,6-trinitrotoluene in transgenic Arabidopsis expressing Citrobacter freundii nitroreductase

Biotechnology & Biotechnological Equipment, 2022
The degradation of organic pollutants in plants involves uptake and diffusion through the roots, trunk or leaves, transformation, accumulation and/or volatilization of soil- and aqueous-phase contaminants.
Bo Zhu, Xiyan Hu, Shuanghong You, Jianjie Gao, Xiaoyan Fu, Hongjuan Han, Zhenjun Li, Quanhong Yao   +7 more
doaj   +1 more source

The Pineal Gland Is Required for Optimal Nighttime Immunity to Bacterial Infection in Larval Zebrafish

Journal of Pineal Research, Volume 78, Issue 5, September 2026.
ABSTRACT The immune response to bacterial infection demonstrates circadian rhythmicity, with heightened antibacterial immunity often observed during the daytime. This circadian‐gated immune response is believed to have evolved to synchronize peak antibacterial immunity with the increased threat of infection when active.
Gabriel Anasarias‐Dumo, Yevetta Y. Xiang, David Cumin, James F. Cheeseman, Guy R. Warman, Jonathan W. Astin, Christopher J. Hall   +6 more
wiley   +1 more source