Results 51 to 60 of about 6,658 (162)

Functions of nitroreductases in mycobacterial physiology and drug susceptibility

Journal of Bacteriology
Tuberculosis is a respiratory infection that is caused by members of the Mycobacterium tuberculosis complex, with M. tuberculosis (Mtb) being the predominant cause of the disease in humans.
Ifeanyichukwu E. Eke, Robert B. Abramovitch   +1 more
doaj   +1 more source

Mechanism of Two-/Four-Electron Reduction of Nitroaromatics by Oxygen-Insensitive Nitroreductases: The Role of a Non-Enzymatic Reduction Step

Molecules, 2018
Oxygen-insensitive NAD(P)H:nitroreductases (NR) reduce nitroaromatics (Ar-NO2) into hydroxylamines (Ar-NHOH) through nitroso (Ar-NO) intermediates. Ar-NO may be reduced both enzymatically and directly by reduced nicotinamide adenine dinucleotide or its ...
Benjaminas Valiauga, Lina Misevičienė, Michelle H. Rich, David F. Ackerley, Jonas Šarlauskas, Narimantas Čėnas   +5 more
doaj   +1 more source

Toxicity and degradation of 2,4,6-trinitrotoluene in transgenic Arabidopsis expressing Citrobacter freundii nitroreductase

Biotechnology & Biotechnological Equipment, 2022
The degradation of organic pollutants in plants involves uptake and diffusion through the roots, trunk or leaves, transformation, accumulation and/or volatilization of soil- and aqueous-phase contaminants.
Bo Zhu, Xiyan Hu, Shuanghong You, Jianjie Gao, Xiaoyan Fu, Hongjuan Han, Zhenjun Li, Quanhong Yao   +7 more
doaj   +1 more source

Informing Efforts to Develop Nitroreductase for Amine Production

Molecules, 2018
Nitroreductases (NRs) hold promise for converting nitroaromatics to aromatic amines. Nitroaromatic reduction rate increases with Hammett substituent constant for NRs from two different subgroups, confirming substrate identity as a key determinant of ...
Anne-Frances Miller, Jonathan T. Park, Kyle L. Ferguson, Warintra Pitsawong, Andreas S. Bommarius   +4 more
doaj   +1 more source

Molecular Periphery Design Allows Control of the New Nitrofurans Antimicrobial Selectivity

Molecules
A series of 13 new 3-substituted 5-(5-nitro-2-furyl)-1,2,4-oxadiazoles was synthesized from different aminonitriles. All compounds were screened in the disc diffusion test at a 100 μg/mL concentration to determine the bacterial growth inhibition zone ...
Lyubov Vinogradova, Alexey Lukin, Kristina Komarova, Maxim Zhuravlev, Artem Fadeev, Mikhail Chudinov, Elizaveta Rogacheva, Lyudmila Kraeva, Maxim Gureev, Yuri Porozov, Marine Dogonadze, Tatiana Vinogradova   +11 more
doaj   +1 more source

Advanced nanotherapeutics for combating ocular infections: Rational design, antimicrobial mechanisms, and therapeutic breakthroughs

BMEMat, Volume 4, Issue 3, September 2026.
Nanomaterials revolutionize ocular infection treatment by enabling targeted drug delivery and enhanced antimicrobial efficacy against resistant pathogens. This review systematically explores their rational design, multimodal mechanisms, and translational potential for next‐generation anti‐infective therapies.
Yujia Liu, Xuetian Wen, Yue Tan, Rui Zeng, Yijuan Zhang, Tong Lin, Lan Gong, Zichao Luo   +7 more
wiley   +1 more source

Bioinformatic analysis and characterization of the enzyme SE1966 - A putative nitroreductase

, 2022
The Protein Structure Initiative (PSI) was a 15 year, $70 million program with the goal of solving large numbers of protein structures, expanding basic and biomedical research.
Langlois, Allison
core   +1 more source

Uptake, metabolism, and bioremediation of neonicotinoid insecticides in soil–plant systems: A review

New Plant Protection, Volume 3, Issue 3, September 2026.
This review summarizes the uptake and metabolic transformation of neonicotinoid insecticides in plants, showing that some metabolites exhibit higher toxicity. We also critically assess promising bioremediation strategies using microbes and plant–microbe interactions to reduce residue contamination.
Wenwen Guo, Jiayue Liu, Yichen Yang, Hui Li, Runan Li, Yuanbo Li   +5 more
wiley   +1 more source

Recent Advances in Food Allergens and Emerging Biosensing Technologies

Comprehensive Reviews in Food Science and Food Safety, Volume 25, Issue 5, September 2026.
ABSTRACT Food allergies have become a worldwide public health issue, highlighting the critical need for rapid, sensitive, and field‐deployable detection strategies. While traditional detection methods offer high accuracy, their high cost, operational complexity, and lengthy analysis time limit their applicability for rapid screening purposes.
Maojie Hu, Youfa Wang, Yuxin Wang, Liqiushi Deng, Geoffrey I. N. Waterhouse, Vijaya Raghavan, Jin Wang   +6 more
wiley   +1 more source

A coelenterazine-type bioluminescent probe for nitroreductase imaging

, 2018
Novel coelenterazine-type bioluminescent probes have been designed and synthesized to detect nitroreductase (NTR) in hypoxic tumors.
Zhenzhen Li, Tianyu Jiang, Lupei Du, Xingye Yang, Minyong Li   +4 more
core   +1 more source