Results 41 to 50 of about 71,065 (294)
Tetrazine-mediated bioorthogonal prodrug–prodrug activation
Chemical Science, 2018 Prodrug–prodrug activation describes the simultaneous, traceless and bioorthogonal activation of two drugs.
Kevin Neumann +3 more
openaire +4 more sources
Molecules, 2008 The purpose of this work is to review the published strategies for the productionof prodrugs of amines. The review is divided in two main groups of approaches: those thatrely on enzymatic activation and those that take advantage of physiological chemicalconditions for release of the drugs.
John F. Gilmer +2 more
openaire +3 more sources
Prodrug-Based Cascade Self-Assembly Strategy for Precisely Controlled Combination Drug Therapy
, 2018 The development of codelivery systems for combination therapy that can load different drugs in a single carrier and precisely deliver payloads (ratio and administration time) via programmable administration has proven to be challenging.
Wei Ha (836306) +4 more
core +1 more source
Journal of Functional Biomaterials, 2019 Directed enzyme prodrug therapy (DEPT) involves the delivery of a prodrug-activating enzyme to a solid tumour site, followed by the subsequent activation of an administered prodrug.
Simon D. Anderson +6 more
doaj +1 more source
Molecules, 2021 In the area of gene-directed enzyme prodrug therapy (GDEPT), using herpes simplex virus thymidine kinase (HSV-tk) paired with prodrug ganciclovir (GCV) for cancer treatment has been extensively studied. It is a process involved with two steps whereby the
Alicia J. Sawdon +4 more
doaj +1 more source
Conditions for safe and effective ADEPT treatment [PDF]
, 2010 Antibody directed enzyme prodrug therapy (ADEPT) is a drug delivery system developed for the treatment of cancer. ADEPT uses a systemically administered antibody, tethered to an enzyme, to localize enzyme in tumour deposits.
Wilkins, D.K.
core
FEBS Open Bio, EarlyView.UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová +2 more
wiley +1 more source
Brain Delivery of Thyrotropin-Releasing Hormone via a Novel Prodrug Approach
Pharmaceutics, 2019 Using thyrotropin-releasing hormone (TRH) as a model, we explored whether synergistic combination of lipoamino acid(s) and a linker cleaved by prolyl oligopeptidase (POP) can be used as a promoiety for prodrug design for the preferential brain delivery ...
Katalin Prokai-Tatrai +5 more
doaj +1 more source
Electrodrugs: An electrochemical prodrug activation strategy
, 2018 Dataset corresponding to manuscript entitled "Electrodrugs: an electrochemical prodrug activation strategy"
Murray, Alan +7 more
core +1 more source
A prodrug activated by H2O2 and mitochondrial hydroxide: an improvement of cancer cells versus neutrophils selectivity [PDF]
, 2023 Many known chemotherapeutic anticancer agents exhibit neutropenia as a dose-limiting side effect. In this paper we suggest a prodrug concept solving this problem for camptothecin (HO-cpt). The prodrug is programmed according to Boolean “AND” logic.
Tina, Jost +18 more
core +2 more sources