Results 21 to 30 of about 73,102 (302)
MethodsX, 2020 Bacterial-directed enzyme-prodrug therapy (BDEPT) uses tumour-tropic bacteria armed with a genetically-encoded prodrug-converting enzyme to sensitise tumours to a systemically-administered prodrug.
Jasmine V.E. Chan-Hyams +1 more
doaj +1 more source
Orthogonal Light- and Enzyme-Triggered and-Gate Prodrugs for Senolytic Therapy. [PDF]
Adv Sci (Weinh)An orthogonal AND‐gate prodrug platform combines 390 nm near‐UV photocleavage with SA‐β‐gal activation to control payload release in senescent cells. Its modular architecture enables 4‐MU fluorescence, doxorubicin‐mediated cytotoxicity, and ARV‐771‐driven BRD4 degradation, supporting stimulus‐controlled senolytic design in cellular and organoid models.
Chang M +12 more
europepmc +2 more sources
Electrodrugs: An electrochemical prodrug activation strategy
, 2018 Dataset corresponding to manuscript entitled "Electrodrugs: an electrochemical prodrug activation strategy"
Murray, Alan +7 more
core +2 more sources
A New Classification of Prodrugs: Regulatory Perspectives
Pharmaceuticals, 2009 Many therapeutic agents are manufactured and administered in prodrug forms. In this paper, a new classification system for prodrugs is proposed to provide useful information about where in the body a prodrug is converted to the active drug.
Kuei-Meng Wu
doaj +1 more source
Dimensionless parameter predicts bacterial prodrug success
Molecular Systems Biology, 2022 Understanding mechanisms of antibiotic failure is foundational to combating the growing threat of multidrug‐resistant bacteria. Prodrugs—which are converted into a pharmacologically active compound after administration—represent a growing class of ...
Brandon Alexander Holt +7 more
doaj +1 more source
Reduction-Responsive Stearyl Alcohol-Cabazitaxel Prodrug Nanoassemblies for Cancer Chemotherapy
Pharmaceutics, 2023 Cabazitaxel (CTX) has distinct therapeutic merits for advanced and metastatic cancer. However, the present clinical formulation (Jevtana®) has several defects, especially for undesirable tumor-targeting and serious side effects, greatly limiting the ...
Yuting Liu +6 more
doaj +1 more source
Pharmaceutics, 2020 Self-assembled prodrugs (SAPDs), which combine prodrug strategy and the merits of self-assembly, not only represent an appealing type of therapeutics, enabling the spontaneous organization of supramolecular nanocomposites with defined structures in ...
Jingyan Gao +7 more
doaj +1 more source
Iraqi Journal of Pharmaceutical Sciences, 2017 On the basis of known coumarin-based prodrug system, a novel coumarin-based mutual prodrug of 5-fluorouracil and dichloroacetic acid was designed, synthesized and evaluated as a promising oral chemotherapeutic agent basing on in vitro stability study in ...
Yasser F. Mustafa, Nohad A. Al-Omari
doaj +3 more sources
Prodrug-Based Cascade Self-Assembly Strategy for Precisely Controlled Combination Drug Therapy
, 2018 The development of codelivery systems for combination therapy that can load different drugs in a single carrier and precisely deliver payloads (ratio and administration time) via programmable administration has proven to be challenging.
Wei Ha (836306) +4 more
core +1 more source
Fuplatin: An Efficient and Low-Toxic Dual-Prodrug
, 2019 As FDA-approved chemotherapeutic agents, cisplatin, oxaliplatin, and 5-fluorouracil are widely used in clinic but limited by severe side-effects. To ameliorate their respective defects, a series of “dual-prodrug” by linking oxoplatin and 5-FU were ...
Ran Zhang +9 more
core +2 more sources