Results 31 to 40 of about 71,065 (294)
Reversing Temozolomide Resistance in Glioblastoma Based on Cuproptosis-Mediated Positive Feedback Loop. [PDF]
Adv Sci (Weinh)To effectively reverse TMZ resistance, this work proposes a cuproptosis‐mediated positive feedback loop that integrates mitochondrial dysfunction, ATP depletion, AMPK‐p53 signaling, and glycolytic inhibition, ultimately amplifying cell death. This cuproptosis‐mediated feedback loop simultaneously disrupts multiple resistance pathways in GBM, including ...
Feng W +9 more
europepmc +2 more sources
Pharmaceutics, 2020 Self-assembled prodrugs (SAPDs), which combine prodrug strategy and the merits of self-assembly, not only represent an appealing type of therapeutics, enabling the spontaneous organization of supramolecular nanocomposites with defined structures in ...
Jingyan Gao +7 more
doaj +1 more source
Safety, pharmacokinetic, and efficacy studies of oral DB868 in a first stage vervet monkey model of human African trypanosomiasis [PDF]
, 2013 There are no oral drugs for human African trypanosomiasis (HAT, sleeping sickness). A successful oral drug would have the potential to reduce or eliminate the need for patient hospitalization, thus reducing healthcare costs of HAT.
Arlene S. Bridges (301008) +65 more
core +2 more sources
Fuplatin: An Efficient and Low-Toxic Dual-Prodrug
, 2019 As FDA-approved chemotherapeutic agents, cisplatin, oxaliplatin, and 5-fluorouracil are widely used in clinic but limited by severe side-effects. To ameliorate their respective defects, a series of “dual-prodrug” by linking oxoplatin and 5-FU were ...
Ran Zhang +9 more
core +2 more sources
Iraqi Journal of Pharmaceutical Sciences, 2017 On the basis of known coumarin-based prodrug system, a novel coumarin-based mutual prodrug of 5-fluorouracil and dichloroacetic acid was designed, synthesized and evaluated as a promising oral chemotherapeutic agent basing on in vitro stability study in ...
Yasser F. Mustafa, Nohad A. Al-Omari
doaj +3 more sources
Precision Oncology via Radiotherapy-Triggered Drug Delivery: Mechanisms, Molecular Engineering, and Clinical Translation. [PDF]
Adv Sci (Weinh)This review redefines radiotherapy‐triggered drug delivery systems through structural disassembly and molecular actuation, proposing a translation‐oriented framework for dose‐correlated activation to advance clinically integrated precision oncology. ABSTRACT Radiotherapy‐triggered drug delivery systems (RDDS) promise to integrate the spatial precision ...
Jiang J, Zhang T, Dong J, Sun W.
europepmc +2 more sources
Coarse-Grained Model-Assisted Design of Optimized Polymer Prodrug Nanoparticles: A Combined Theoretical and Experimental Study [PDF]
, 2023 To achieve efficient drug release from polymer prodrug nanoparticles, the drug-polymer linker must be accessible for cleavage to release the drug, which can occur under certain physiological conditions (e.g., presence of specific enzymes). Supramolecular
Tâp, Ha-Duong +2 more
core +2 more sources
Quick Pharmaceutical steps for preliminary evaluation of a compund as a possible oral prodrug
Al-Mustansiriyah Journal of Pharmaceutical Sciences, 2011 A mutual prodrug is the association in a unique molecule of two, usually synergetic drugs attached to each other. Mutual prodrug of aspirin with paracetamol as a model oral prodrug was prepared and identified and many pharmaceutical steps were applied ...
Nidhal Khazaal +3 more
doaj +1 more source
Drug Delivery, 2017 Breast cancer leads to high mortality of women in the world. Docetaxel (DTX) has been widely applied as one of the first-line chemotherapeutic drugs for breast cancer therapy.
Shenwu Zhang +11 more
doaj +1 more source
Pharmaceutics, 2021 The bacterial nitroreductase NfnB has been the focus of a great deal of research for its use in directed enzyme prodrug therapy in combination with the nitroreductase prodrug CB1954 with this combination of enzyme and prodrug even entering clinical ...
Patrick Ball +6 more
doaj +1 more source