Results 31 to 40 of about 65,300 (300)

Safety, pharmacokinetic, and efficacy studies of oral DB868 in a first stage vervet monkey model of human African trypanosomiasis [PDF]

, 2013
There are no oral drugs for human African trypanosomiasis (HAT, sleeping sickness). A successful oral drug would have the potential to reduce or eliminate the need for patient hospitalization, thus reducing healthcare costs of HAT.
Arlene S. Bridges (301008), Shelley Ching, Bridges, Arlene S., Raymond E Mdachi, Brun Reto, Wang Michael Zhuo, Wang, Michael Zhuo, Wolf, Kristina K., Ching, Shelley, Arlene S Bridges, Mutuku James N., Murilla, Grace A., Paine, Mary F., Boykin, David W., James N Mutuku, Richard R Tidwell, Mohamed A Ismail, John K. Thuita (148377), Liu, Qiang, Tidwell, Richard R., Hall, James E., Mary F. Paine (148396), John K Thuita, Bridges Arlene S., Ismail Mohamed A., Mdachi, Raymond E., Qiang Liu (166143), Mdachi Raymond E., David W. Boykin (148406), Reto Brun, Reto Brun (41511), Ching Shelley, Hall, James Edwin, Shelley Ching (148404), Tidwell Richard R., Chen, Yao, Mohamed A. Ismail (418629), Boykin David W., Mutuku, James N., James Edwin Hall, Qiang Liu, Grace A Murilla, Hall James Edwin, Raymond E. Mdachi (148398), Mary F Paine, Liu Qiang, Kristina K. Wolf (418627), Michael Zhuo Wang, Thutia, John K., David W Boykin, Yao Chen (149006), Grace A. Murilla (148401), Ismail, Mohamed A., Michael Zhuo Wang (418631), Murilla Grace A., Wolf Kristina K., Kristina K Wolf, James Edwin Hall (418630), Thuita John K., James N. Mutuku (418628), Brun, Reto, Yao Chen, Thuita, John K., Richard R. Tidwell (148409), Paine Mary F., Chen Yao   +65 more
core   +1 more source

Stimuli-Sensitive Polymer Prodrug Nanocarriers by Reversible-Deactivation Radical Polymerization

, 2023
Polymer prodrugs are based on the covalent linkage of therapeutic molecules to a polymer structure which avoids the problems and limitations commonly encountered with traditional drug-loaded nanocarriers in which drugs are just physically entrapped (e.g.,
Amaury, Bossion, Marianne, Ferrere, Léa, Guerassimoff, Julien, Nicolas   +3 more
core   +1 more source

Quick Pharmaceutical steps for preliminary evaluation of a compund as a possible oral prodrug

Al-Mustansiriyah Journal of Pharmaceutical Sciences, 2011
A mutual prodrug is the association in a unique molecule of two, usually synergetic drugs attached to each other. Mutual prodrug of aspirin with paracetamol as a model oral prodrug was prepared and identified and many pharmaceutical steps were applied ...
Nidhal Khazaal, Mazen Taha, Masar Basim, Hasanain Amer   +3 more
doaj   +1 more source

Fuplatin: An Efficient and Low-Toxic Dual-Prodrug

, 2019
As FDA-approved chemotherapeutic agents, cisplatin, oxaliplatin, and 5-fluorouracil are widely used in clinic but limited by severe side-effects. To ameliorate their respective defects, a series of “dual-prodrug” by linking oxoplatin and 5-FU were ...
Rui-Ping Liu (2062048), Jing-Yuan Xu (666612), Xue-Qing Song (6400193), Ran Zhang (117374), Zhong-Ying Ma (666610)   +4 more
core   +2 more sources

The YfkO Nitroreductase from Bacillus Licheniformis on Gold-Coated Superparamagnetic Nanoparticles: Towards a Novel Directed Enzyme Prodrug Therapy Approach

Pharmaceutics, 2021
The bacterial nitroreductase NfnB has been the focus of a great deal of research for its use in directed enzyme prodrug therapy in combination with the nitroreductase prodrug CB1954 with this combination of enzyme and prodrug even entering clinical ...
Patrick Ball, Robert Hobbs, Simon Anderson, Emma Thompson, Vanessa Gwenin, Christopher Von Ruhland, Christopher Gwenin   +6 more
doaj   +1 more source

Duocarmycin-based prodrugs for cancer prodrug monotherapy

Bioorganic & Medicinal Chemistry, 2008
The synthesis and biological evaluation of novel prodrugs based on the cytotoxic antibiotic duocarmycin SA (1) for a selective treatment of cancer using a prodrug monotherapy (PMT) are described. Transformation of the phenol 8 with the glucuronic acid benzyl ester trichloroacetimidate 9b followed by reaction with DMAI x HCl (10) gives the glucuronide ...
Tietze, Lutz Friedjan, Schuster, Heiko J., Schmuck, Kianga, Schuberth, Ingrid, Alves, Frauke   +4 more
openaire   +3 more sources

Cell-Penetrating Peptides as a Tool for the Cellular Uptake of a Genetically Modified Nitroreductase for use in Directed Enzyme Prodrug Therapy

Journal of Functional Biomaterials, 2019
Directed enzyme prodrug therapy (DEPT) involves the delivery of a prodrug-activating enzyme to a solid tumour site, followed by the subsequent activation of an administered prodrug.
Simon D. Anderson, Robert J. Hobbs, Vanessa V. Gwenin, Patrick Ball, Lindsey A. Bennie, Jonathan A. Coulter, Chris D. Gwenin   +6 more
doaj   +1 more source

Prodrug-Based Cascade Self-Assembly Strategy for Precisely Controlled Combination Drug Therapy

, 2018
The development of codelivery systems for combination therapy that can load different drugs in a single carrier and precisely deliver payloads (ratio and administration time) via programmable administration has proven to be challenging.
Wei Ha (836306), Xin-yue Chen (5407259), Kan Jiang (1590202), Yan-ping Shi (1713616), Xiao-bo Zhao (5407262)   +4 more
core   +1 more source

Brain Delivery of Thyrotropin-Releasing Hormone via a Novel Prodrug Approach

Pharmaceutics, 2019
Using thyrotropin-releasing hormone (TRH) as a model, we explored whether synergistic combination of lipoamino acid(s) and a linker cleaved by prolyl oligopeptidase (POP) can be used as a promoiety for prodrug design for the preferential brain delivery ...
Katalin Prokai-Tatrai, Daniel L. De La Cruz, Vien Nguyen, Benjamin P. Ross, Istvan Toth, Laszlo Prokai   +5 more
doaj   +1 more source

Polymeric Nanovectors Incorporated with Ganciclovir and HSV-tk Encoding Plasmid for Gene-Directed Enzyme Prodrug Therapy

Molecules, 2021
In the area of gene-directed enzyme prodrug therapy (GDEPT), using herpes simplex virus thymidine kinase (HSV-tk) paired with prodrug ganciclovir (GCV) for cancer treatment has been extensively studied. It is a process involved with two steps whereby the
Alicia J. Sawdon, Jun Zhang, Sarah Peng, Esmael M. Alyami, Ching-An Peng   +4 more
doaj   +1 more source