Results 31 to 40 of about 73,102 (302)

Quick Pharmaceutical steps for preliminary evaluation of a compund as a possible oral prodrug

Al-Mustansiriyah Journal of Pharmaceutical Sciences, 2011
A mutual prodrug is the association in a unique molecule of two, usually synergetic drugs attached to each other. Mutual prodrug of aspirin with paracetamol as a model oral prodrug was prepared and identified and many pharmaceutical steps were applied ...
Nidhal Khazaal, Mazen Taha, Masar Basim, Hasanain Amer   +3 more
doaj   +1 more source

Complementation Dependent Enzyme Prodrug Therapy Enables Targeted Activation of Prodrug on HER2-Positive Cancer Cells

, 2022
Antibodies have been explored for decades for the delivery of small molecule cytotoxins directly to diseased cells. In antibody-directed enzyme prodrug therapy (ADEPT), antibodies are armed with enzymes that activate nontoxic prodrugs at tumor sites ...
Shawn C. Owen (1279323), Samuel T. Hatch (14034564), Christine S. Nervig (14034561)   +2 more
core   +1 more source

The YfkO Nitroreductase from Bacillus Licheniformis on Gold-Coated Superparamagnetic Nanoparticles: Towards a Novel Directed Enzyme Prodrug Therapy Approach

Pharmaceutics, 2021
The bacterial nitroreductase NfnB has been the focus of a great deal of research for its use in directed enzyme prodrug therapy in combination with the nitroreductase prodrug CB1954 with this combination of enzyme and prodrug even entering clinical ...
Patrick Ball, Robert Hobbs, Simon Anderson, Emma Thompson, Vanessa Gwenin, Christopher Von Ruhland, Christopher Gwenin   +6 more
doaj   +1 more source

Tetrazine-mediated bioorthogonal prodrug–prodrug activation

Chemical Science, 2018
Prodrug–prodrug activation describes the simultaneous, traceless and bioorthogonal activation of two drugs.
Kevin Neumann, Alessia Gambardella, Annamaria Lilienkampf, Mark Bradley   +3 more
openaire   +4 more sources

Cell-Penetrating Peptides as a Tool for the Cellular Uptake of a Genetically Modified Nitroreductase for use in Directed Enzyme Prodrug Therapy

Journal of Functional Biomaterials, 2019
Directed enzyme prodrug therapy (DEPT) involves the delivery of a prodrug-activating enzyme to a solid tumour site, followed by the subsequent activation of an administered prodrug.
Simon D. Anderson, Robert J. Hobbs, Vanessa V. Gwenin, Patrick Ball, Lindsey A. Bennie, Jonathan A. Coulter, Chris D. Gwenin   +6 more
doaj   +1 more source

Prodrugs for Amines [PDF]

Molecules, 2008
The purpose of this work is to review the published strategies for the productionof prodrugs of amines. The review is divided in two main groups of approaches: those thatrely on enzymatic activation and those that take advantage of physiological chemicalconditions for release of the drugs.
John F. Gilmer, John M. Clancy, Ana L. Simplício   +2 more
openaire   +3 more sources

Dual Killing Strategy: Photocatalytic Generation of Singlet Oxygen with Concomitant Pt(IV) Prodrug Activation [PDF]

, 2019
Norman, D. (2019). Dual Killing Strategy: Photocatalytic Generation of Singlet Oxygen with Concomitant Pt(IV) Prodrug Activation, [dataset]. University of Edinburgh.
Norman, Daniel, School of Chemistry, Norman, D   +2 more
core   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Polymeric Nanovectors Incorporated with Ganciclovir and HSV-tk Encoding Plasmid for Gene-Directed Enzyme Prodrug Therapy

Molecules, 2021
In the area of gene-directed enzyme prodrug therapy (GDEPT), using herpes simplex virus thymidine kinase (HSV-tk) paired with prodrug ganciclovir (GCV) for cancer treatment has been extensively studied. It is a process involved with two steps whereby the
Alicia J. Sawdon, Jun Zhang, Sarah Peng, Esmael M. Alyami, Ching-An Peng   +4 more
doaj   +1 more source

Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA

FEBS Open Bio, EarlyView.
Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley   +1 more source