Results 11 to 20 of about 73,102 (302)
Drug Delivery, 2017 Breast cancer leads to high mortality of women in the world. Docetaxel (DTX) has been widely applied as one of the first-line chemotherapeutic drugs for breast cancer therapy.
Shenwu Zhang +11 more
doaj +2 more sources
Aryloxy Pivaloyloxymethyl Prodrugs as Nucleoside Monophosphate Prodrugs [PDF]
Journal of Medicinal Chemistry, 2021 Intracellular phosphorylation of therapeutic nucleoside analogues into their active triphosphate metabolites is a prerequisite for their pharmacological activity. However, the initial phosphorylation of these unnatural nucleosides into their monophosphate derivatives can be a rate-limiting step in their activation. To address this, we herein report the
Ashwag S. Alanazi +2 more
openaire +2 more sources
Desymmetrization of Pibrentasvir for Efficient Prodrug Synthesis [PDF]
, 2021 A novel and practical desymmetrization tactic is described to access a new class of pibrentasvir prodrugs. The homotopic benzimidazoles of pibrentasvir (PIB) are differentiated via a one-pot di-Boc/mono-de-Boc selective N-Boc protection and formaldehyde ...
Jan E., Waters +8 more
core +2 more sources
Morphine is not a prodrug [PDF]
British Journal of Anaesthesia, 2015 Editor–A prodrug is defined as a medication that is administered in an inactive or less than fully active form and is then converted to its active form through a normal metabolic process (http://en. wikipedia.org/wiki/Prodrug). The title of a recent publication in the British Journal of Analgesia, ‘Morphine-6-glucuronide is responsible for the ...
A, Dahan, J, Lötsch
openaire +2 more sources
Molecules, 2016 The main objective of this review is to describe the importance of dendrimer prodrugs in the design of new drugs, presenting numerous applications of these nanocomposites in the pharmaceutical field. Therefore, the use of dendrimer prodrugs as carrier for drug delivery, to improve pharmacokinetic properties of prototype, to promote drug sustained ...
Soraya da Silva Santos +2 more
openaire +3 more sources
A CNS-Targeting Prodrug Strategy for Nuclear Receptor Modulators [PDF]
, 2020 Neurodegenerative diseases lack a breadth of treatment options due, in part, to the known difficulties associated with a drug’s passage across the blood-brain barrier.
Skylar, Ferrara, Thomas, Scanlan
core +1 more source
Frontiers in Materials, 2018 Theranostic prodrug plays a vital role in reducing the side effects and evaluating the therapeutic efficiency of prodrug in vivo. In particular, small conjugate-based theranostic prodrugs have attracted much attention because of their clear and simple ...
Sanpeng Li +14 more
doaj +1 more source
Stimuli-Sensitive Polymer Prodrug Nanocarriers by Reversible-Deactivation Radical Polymerization [PDF]
, 2023 Polymer prodrugs are based on the covalent linkage of therapeutic molecules to a polymer structure which avoids the problems and limitations commonly encountered with traditional drug-loaded nanocarriers in which drugs are just physically entrapped (e.g.,
Amaury, Bossion +3 more
core +1 more source
Molecules, 2008 Parkinson`s disease (PD) is a progressive, neurodegenerative disorder whichinvolves the loss of dopaminergic neurons of the substantia nigra pars compacta. Currenttherapy is essentially symptomatic, and L-Dopa (LD), the direct precursor of dopamine(DA), is the treatment of choice in more advanced stages of the disease.
DI STEFANO, Antonio +2 more
openaire +4 more sources
Pharmaceuticals, 2014 The N-ethoxycarbonylmorpholine moiety was evaluated as a novel prodrug moiety for carboxylic acid containing drugs represented by diclofenac (1).
Jamal A. Jilani +2 more
doaj +1 more source