Results 11 to 20 of about 73,540 (330)
Drug Design, Development and Therapy, 2016 Zaman Ashraf,1,2 Alamgeer,3 Munazza Kanwal,1 Mubashir Hassan,2 Sahar Abdullah,3 Mamuna Waheed,3 Haseeb Ahsan,3 Song Ja Kim2 1Department of Chemistry, Allama Iqbal Open University, Islamabad, Pakistan; 2Department of Biological Sciences, College of ...
Ashraf Z +7 more
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Chemical Society Reviews, 2017 Covalent modification of therapeutic compounds is a clinically proven strategy to devise prodrugs with enhanced treatment efficacies. This prodrug strategy relies on modified drugs that possess advantageous pharmacokinetic properties and administration ...
A. Cheetham +3 more
semanticscholar +2 more sources
Reversing Temozolomide Resistance in Glioblastoma Based on Cuproptosis-Mediated Positive Feedback Loop. [PDF]
Adv Sci (Weinh)To effectively reverse TMZ resistance, this work proposes a cuproptosis‐mediated positive feedback loop that integrates mitochondrial dysfunction, ATP depletion, AMPK‐p53 signaling, and glycolytic inhibition, ultimately amplifying cell death. This cuproptosis‐mediated feedback loop simultaneously disrupts multiple resistance pathways in GBM, including ...
Feng W +9 more
europepmc +2 more sources
Aryloxy Pivaloyloxymethyl Prodrugs as Nucleoside Monophosphate Prodrugs [PDF]
Journal of Medicinal Chemistry, 2021 Intracellular phosphorylation of therapeutic nucleoside analogues into their active triphosphate metabolites is a prerequisite for their pharmacological activity. However, the initial phosphorylation of these unnatural nucleosides into their monophosphate derivatives can be a rate-limiting step in their activation. To address this, we herein report the
Ashwag S. Alanazi +2 more
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smProdrugs: A repository of small molecule prodrugs [PDF]
, 2022 In modern drug discovery and development, the prodrug approach has become a crucial strategy for enhancing the pharmacokinetic profiles of drugs. A prodrug is a chemical compound, which gets metabolized into a pharmacologically active form (drug) inside ...
Vivek, Kumar, Chinmayee, Choudhury
core +2 more sources
Morphine is not a prodrug [PDF]
British Journal of Anaesthesia, 2015 Editor–A prodrug is defined as a medication that is administered in an inactive or less than fully active form and is then converted to its active form through a normal metabolic process (http://en. wikipedia.org/wiki/Prodrug). The title of a recent publication in the British Journal of Analgesia, ‘Morphine-6-glucuronide is responsible for the ...
A, Dahan, J, Lötsch
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Recent Development of Prodrugs of Gemcitabine
Genes, 2022 Gemcitabine is a nucleoside analog that has been used widely as an anticancer drug for the treatment of a variety of conditions, including ovarian, bladder, non-small-cell lung, pancreatic, and breast cancer. However, enzymatic deamination, fast systemic
Bhoomika Pandit, M. Royzen
semanticscholar +1 more source
Stimulus-responsive self-assembled prodrugs in cancer therapy
Chemical Science, 2022 Small-molecule prodrugs have become the main toolbox to improve the unfavorable physicochemical properties of potential therapeutic compounds in contemporary anti-cancer drug development.
Xiao-Wu Dong +3 more
semanticscholar +1 more source
N-Alkylaminoferrocene-Based Prodrugs Targeting Mitochondria of Cancer Cells
Molecules, 2020 Intracellular concentration of reactive oxygen species (e.g., H2O2) in cancer cells is elevated over 10-fold as compared to normal cells. This feature has been used by us and several other research groups to design cancer specific prodrugs, for example ...
Viktor Reshetnikov +7 more
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Chemical Characterization and Pharmacological Evaluation of Phytophenols-Etodolac Mutual Prodrugs
Iraqi Journal of Pharmaceutical Sciences, 2023 Etodolac is choice of drug for pain and inflammation but has major side effects of gastric ulcers that are due to free carboxylic group. Etodolac belongs to the chemical class of non-selective COX-inhibitor but preferentially COX-2 inhibitor.
Kamal Shah, Gaurav Krishna
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