Results 11 to 20 of about 33,100 (295)
Molecules, 2016 The main objective of this review is to describe the importance of dendrimer prodrugs in the design of new drugs, presenting numerous applications of these nanocomposites in the pharmaceutical field.
Soraya da Silva Santos +2 more
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Drug Design, Development and Therapy, 2016 Zaman Ashraf,1,2 Alamgeer,3 Munazza Kanwal,1 Mubashir Hassan,2 Sahar Abdullah,3 Mamuna Waheed,3 Haseeb Ahsan,3 Song Ja Kim2 1Department of Chemistry, Allama Iqbal Open University, Islamabad, Pakistan; 2Department of Biological Sciences, College of ...
Ashraf Z +7 more
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Aryloxy Pivaloyloxymethyl Prodrugs as Nucleoside Monophosphate Prodrugs [PDF]
Journal of Medicinal Chemistry, 2021 Intracellular phosphorylation of therapeutic nucleoside analogues into their active triphosphate metabolites is a prerequisite for their pharmacological activity. However, the initial phosphorylation of these unnatural nucleosides into their monophosphate derivatives can be a rate-limiting step in their activation. To address this, we herein report the
Ashwag S. Alanazi +2 more
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smProdrugs: A repository of small molecule prodrugs [PDF]
, 2022 In modern drug discovery and development, the prodrug approach has become a crucial strategy for enhancing the pharmacokinetic profiles of drugs. A prodrug is a chemical compound, which gets metabolized into a pharmacologically active form (drug) inside ...
Vivek, Kumar +3 more
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Morphine is not a prodrug [PDF]
British Journal of Anaesthesia, 2015 Editor–A prodrug is defined as a medication that is administered in an inactive or less than fully active form and is then converted to its active form through a normal metabolic process (http://en. wikipedia.org/wiki/Prodrug). The title of a recent publication in the British Journal of Analgesia, ‘Morphine-6-glucuronide is responsible for the ...
A, Dahan, J, Lötsch
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Aryl phosphoramidates of 5-phospho erythronohydroxamic acid, a new class of potent Trypanocidal compounds [PDF]
, 2010 RNAi and enzymatic studies have shown the importance of 6-phosphogluconate dehydrogenase (6-PGDH) in Trypanosoma brucei for the parasite survival and make it an attractive drug target for the development of new treatments against human African ...
Ruda, Gian Filippo +20 more
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Asian Journal of Pharmaceutical Sciences, 2021 Disulfide bond-bridging strategy has been extensively utilized to construct tumor specificity-responsive aliphatic prodrug nanoparticles (PNPs) for precise cancer therapy.
Yuequan Wang +10 more
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Increased/Targeted Brain (Pro)Drug Delivery via Utilization of Solute Carriers (SLCs)
Pharmaceutics, 2022 Membrane transporters have a crucial role in compounds’ brain drug delivery. They allow not only the penetration of a wide variety of different compounds to cross the endothelial cells of the blood–brain barrier (BBB), but also the accumulation of them ...
Johanna Huttunen +3 more
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Dopamine and Levodopa Prodrugs for the Treatment of Parkinson’s Disease
Molecules, 2017 Background: Parkinson’s disease is an aggressive and progressive neurodegenerative disorder that depletes dopamine (DA) in the central nervous system.
Fatma Haddad +4 more
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Molecules, 2022 In past decades, anticancer research has led to remarkable results despite many of the approved drugs still being characterized by high systemic toxicity mainly due to the lack of tumor selectivity and present pharmacokinetic drawbacks, including low ...
Giuseppina Ioele +6 more
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