Results 51 to 60 of about 73,540 (330)

Dansyl linked solid phase resins as an educational tool to teach the concepts of high throughput screening and prodrugs.

British Journal of Pharmacy, 2023
High throughput screening (HTS) and combinatorial chemistry, have been part of the process of drug design for nearly two decades. However, methods to teach their practical aspects to undergraduate students are scarce in the literature.
Jordi Morral, Ali Ibrahim, Fatima Traore, Klaus Pors   +3 more
doaj   +1 more source

Precisely Tailoring Molecular Structure of Doxorubicin Prodrugs to Enable Stable Nanoassembly, Rapid Activation, and Potent Antitumor Effect

Pharmaceutics
Background: Achieving a balance between stable drug loading/delivery and on-demand drug activation/release at the target sites remains a significant challenge for nanomedicines.
Chengcheng Feng, Yu-Ting Wang, Jiaxu Xu, Yanzi Zheng, Wen-Hu Zhou, Yuequan Wang, Cong Luo   +6 more
semanticscholar   +1 more source

Tetrazine-mediated bioorthogonal prodrug–prodrug activation

Chemical Science, 2018
Prodrug–prodrug activation describes the simultaneous, traceless and bioorthogonal activation of two drugs.
Kevin Neumann, Alessia Gambardella, Annamaria Lilienkampf, Mark Bradley   +3 more
openaire   +4 more sources

Investigating the crucial roles of aliphatic tails in disulfide bond-linked docetaxel prodrug nanoassemblies

Asian Journal of Pharmaceutical Sciences, 2021
Disulfide bond-bridging strategy has been extensively utilized to construct tumor specificity-responsive aliphatic prodrug nanoparticles (PNPs) for precise cancer therapy.
Yuequan Wang, Cong Luo, Shuang Zhou, Xinhui Wang, Xuanbo Zhang, Shumeng Li, Shenwu Zhang, Shuo Wang, Bingjun Sun, Zhonggui He, Jin Sun   +10 more
doaj   +1 more source

Disulfide based prodrugs for cancer therapy

RSC Advances, 2020
Advances in the tumor microenvironment have facilitated the development of novel anticancer drugs and delivery vehicles for improved therapeutic efficacy and decreased side effects.
Qiang Wang, Jiankun Guan, Jiangling Wan, Zifu Li   +3 more
semanticscholar   +1 more source

Glucocorticoids-based prodrug design: Current strategies and research progress

Asian Journal of Pharmaceutical Sciences
Attributing to their broad pharmacological effects encompassing anti-inflammation, antitoxin, and immunosuppression, glucocorticoids (GCs) are extensively utilized in the clinic for the treatment of diverse diseases such as lupus erythematosus, nephritis,
Hongbing Liu, Muse Ji, Peifu Xiao, Jingxin Gou, Tian Yin, Haibing He, Xing Tang, Yu Zhang   +7 more
doaj   +1 more source

Targeting succinate dehydrogenase with malonate ester prodrugs decreases renal ischemia reperfusion injury

Redox Biology, 2020
Renal ischemia reperfusion (IR) injury leads to significant patient morbidity and mortality, and its amelioration is an urgent unmet clinical need.
Timothy E. Beach, H. Prag, L. Pala, A. Logan, Margaret M. Huang, A. Gruszczyk, Jack L. Martin, Krishnaa Mahbubani, M. Hamed, S. Hosgood, M. Nicholson, A. M. James, R. Hartley, M. Murphy, K. Saeb-Parsy   +14 more
semanticscholar   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Carbamate group as structural motif in drugs: a review of carbamate derivatives used as therapeutic agents

Arhiv za Higijenu Rada i Toksikologiju, 2020
Due to their very good chemical and proteolytic stability, ability to penetrate cell membranes, and resemblance to a peptide bond, carbamate derivatives have received much attention in recent years and got an important role in modern drug discovery and ...
Matošević Ana, Bosak Anita
doaj   +1 more source

Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA

FEBS Open Bio, EarlyView.
Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley   +1 more source