Results 61 to 70 of about 33,100 (295)
Asian Journal of Pharmaceutical Sciences, 2021 Homodimeric prodrug-based self-assembled nanoparticles, with carrier-free structure and ultrahigh drug loading, is drawing more and more attentions. Homodimeric prodrugs are composed of two drug molecules and a pivotal linkage.
Lingxiao Li +9 more
doaj +1 more source
Cyclodextrin prodrugs 2 and 12–23.
, 2018 Cyclodextrin prodrugs 2 and 12–23.
Kevin Cusack (5728823) +11 more
core +1 more source
Advanced Science, EarlyView.A glutathione and ultrasound dual‐responsive cerasome achieves sequential co‐delivery of gemcitabine and BMS1166 in tumors. Chemotherapy priming followed by on‐demand PD‐L1 blockade synergistically amplifies anti‐tumor immunity, inhibiting primary tumor growth, distant metastasis and inducing durable immune memory.
Suhui Sun +9 more
wiley +1 more source
Synthesis and kinetic studies of mutual azo prodrugs of 5-aminosalicylic acid with sulfamethoxazole and trimethoprim as models for colon targeting [PDF]
المجلة العراقية للصيدلة, 2010 In this study, two mutual azo prodrugs were synthesized for colon targeting in a treatment of colonic diverticular disease. The first was synthesized by coupling sulfamethoxazole with salicylic acid; the second was synthesized by coupling one mole of ...
Yasser Fakri Mustafa
doaj +1 more source
Enzyme-mediated activation of prodrugs
The development of potent drugs is always a challenging task and is often complicated by the number of pharmacokinetic and formulation limitations they suffer from.
D'Agostino, Ilaria +2 more
core +1 more source
Structures of active diamidines and corresponding prodrugs.
, 2015 Structures of active diamidines and corresponding prodrugs.
Arlene S. Bridges (301008) +13 more
core +1 more source
Organic Carbon Monoxide Prodrugs [PDF]
, 2019 Ongoing efforts towards the development of CO-based therapeutics have resulted in the generation of novel CO prodrugs that release CO via different triggers or stimuli.
Aghoghovbia, Robert
core +1 more source
Advanced Science, EarlyView.A series of melatonin‐conjugated platinum(IV) prodrugs was functionalized with isocyanate chains (compounds 5‒12). MP‐12C (compound 11) was identified as the lead candidate, with optimal potency and safety. MP‐12C exhibited greater efficacy than cisplatin by increasing intracellular uptake, reshaping the extracellular matrix, activating the cGAS‐STING ...
Linhui Wang +18 more
wiley +1 more source
Ester prodrugs of flurbiprofen: Synthesis, plasma hydrolysis and gastrointestinal toxicity
, 2007 1164-1168Nine alkyl ester prodrugs of flurbiprofen have been synthesized with an aim to reduce it’s gastrointestinal side-effects. The synthesized prodrugs have been subjected to plasma hydrolysis and gastrointestinal toxicity studies.
Ramaa, C S, Rhea Mohan, C. S. Ramaa
core +1 more source
Acta Pharmaceutica Sinica BThe self-assembly prodrugs are usually consisted of drug modules, activation modules, and assembly modules. Keeping the balance between efficacy and safety by selecting suitable modules remains a challenge for developing prodrug nanoassemblies.
Shuo Wang +10 more
doaj +1 more source